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Dr. Sunil K. Raghav

Academics

Degree University/Institution
Masters in ScienceCCS University, Meerut, UP
Ph.D. BiotechnologyIGIB Delhi

Work Experience

Position University/Organisation Period
Scientist FILS, BhubaneswarJanuary 2022 - till date
Scientist EILS, BhubaneswarJanuary 2018 – December 2021
Scientist D & Ramalingaswami FellowILS, BhubaneswarDec 2013 – Dec 2017
ScientistLaboratory of Systems Biology & Genetics, Swiss Federal Institute of Technology (EPFL), Lausanne, SwitzerlandApril 2009-December 2013
Postdoctoral fellowMolecular Immunology Group, Turku Centre for Biotechnology (BTK), FinlandJanuary 2007-March 2009
Senior BotanistBakson Drugs & Pharmaceuticals Pvt Ltd, Parwanoo, HP, IndiaSeptember 2001-April 2002
Research OfficerApril 2000-August 2001Sage Herbals Pvt Ltd, Ghaziabad, UP, India

Awards & Recognition

Research

Details

Immuno-Genomics and Systems Biology

Dendritic cells (DCs) are specialized antigen-presenting cells that upon encounter with pathogens translate that information to naive T cells in nearby secondary lymph nodes to educate them into pathogen-specific T cell subtype such as Th1, Th2, Th17 or Tregs to induce appropriate T & B cell mediated adaptive response. The T cell-mediated adaptive responses are highly specific and optimal to clear the bug or even to kill the tumor cells. There is very little information about how DCs interpret and integrate the multiple pathogen signals to which they are exposed, to induce a signal specific transcriptional program to ensure appropriate and optimal education of the responding T cells is largely unexplored. This decision is decisive, because it determines the balance between recovery and chronic disease or death.

Therefore, the overall aim of IMGSB group is to employ integrative systems level approach to decipher the molecular mechanisms underlying (i) Transcriptional control of immune response generation in DCs, (ii) Engineer DCs to immune-modulate DC immune responses to fine-tune T cell speciation/differentiation, and (iii) Extrapolate the potential of engineered DCs for immune-therapeutic approaches.

Publications

Details
Immuno-Genomics and Systems Biology
Publications in peer-reviewed Journals / patents:

List of publications:

  1. Wadhwa K, Malik S, Balaji S, Thiruvengadam R, Bashyam MD, Bhattacharya PK, Behera B, Bhardwaj P, Biswas NK, Das A, Dey A, Dhotre D, Dias M, Dubey P, Dutta S, Gadepalli R, Gosain M, Goud KI, Gupta NK, Gupta N, Jana P, Jena D, John E, Karunanidhi A, Khan SMS, Khattar S, Paul APK, Kumar S, Maitra A, Modi N, Moorthy M, Nagaraj S, Palakodeti D, Pandey AK, Pandey A, Raghav SK, Ramasubban S, Raghavan S, Harikrishnan S, Krishnamoorthy S, Selvamurugan S, Sardana R, Shouche Y, Singh A, Singh AK, Ramasubramaniyan V, Yadav M, Zahoor D, Narreddy S, Bhatnagar S, Wadhwa N, Das B, Garg PK. orrelation of severity & clinical outcomes of COVID-19 with virus variants: A prospective, multicentre hospital network study. Indian J Med Res, 2024 Feb 9.
  2. Singh P, Sen K, Sa P, Khuntia A, Raghav SK, Swain RK, Sahoo SK. Piperlongumine based nanomedicine impairs glycolytic metabolism in triple negative breast cancer stem cells through modulation of GAPDH & FBP1. Phytomedicine, 2024 Jan:123:155181.
  3. Sen K, Biswas VK, Ghosh A, Prusty S, Nayak SP, Podder S, Gupta B,Raghav SK. NCoR1: a key player regulating mycobacterium tuberculosis Autophagy 2023 Nov 12:1-2.
  4. Biswas VK, Sen K, Ahad A, Jha A, Ghosh A, Prusty S, Swain M, Kumar D, Gupta Bhawna, Raghav SK. NCoR1 controls Mycobacterium tuberculosis growth in myeloid cells by regulating AMPK-mTOR-TFEB axis. PLoS Biology, 2023 Aug 17;21(8):e3002231.
  5. Tripathy A, Swain N, Padhan P, Raghav SK, Gupta B. Lactobacillus rhamnosus reduces CD8+T cell mediated inflammation in patients with rheumatoid arthritis. Immunobiology. 2023 Jul; 228: 152415.
  6. Mallik S, Dodia H, Ghosh A, Srinivasan R, Good L, Raghav SK, Beuria TK. FtsE, the Nucleotide Binding Domain of the ABC Transporter Homolog FtsEX, Regulates Septal PG Synthesis in E. coli. Microbiol Spectr. 2023 Apr 4:e0286322.
  7. Sen K, Pati R, Jha A, Mishra GP, Prusty S, Chaudhary S, Swetalika S, Podder S, Sen A, Swain M, Nanda RK, Raghav SK. NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation. Redox Biol. 2023, 59:102575.
  8. Jha A, Ahad A, Mishra GP, Sen K, Sen A, Smita S, Minz AP, Biswas VK, Tripathy A, Senapati S, Gupta B, Acha-Orbea H, Raghav SK. SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling. Front Immunol. 2022, September 22.
  9. Mohapatra P, Mohanty S, Ansari SA, Shriwas O, Ghosh A, Rath R, Majumdar SKD, Swain RK, Raghav SK, Dash R. CMTM6 attenuates cisplatin-induced cell death in OSCC by regulating AKT/c-Myc-driven ribosome biogenesis. FASEB J. 2022 36: e22566.
  10. Parai D, Choudhary HR, Dash GC, Behera S, Mishra N, Pattnaik D, Raghav SK, Mishra SK, Sahoo SK, Swain A, Mohapatra I, Pattnaik M, Moharana A, Jena SR, Praharaj I, Subhadra S, Kanungo S, Bhattacharya D, Pati S. Dynamicity and persistence of severe acute respiratory syndrome coronavirus-2 antibody response after double dose and the third dose with BBV-152 and AZD1222 vaccines: A prospective, longitudinal cohort study. Front Microbiol. 2022 13: 942659.
  11. Mishra GP, Jha A, Ahad A, Sen K, Sen A, Podder S, Prusty S, Biswas VK, Gupta B, Raghav SK*. Epigenomics of conventional type-I dendritic cells depicted preferential control of TLR9 versus TLR3 response by NCoR1 through differential IRF3 activation. Cell Mol Life Sci. 2022, 79: 429.
  12. Prasad P, Mahapatra S, Mishra R, Murmu KC, Aggarwal S, Sethi M, Mohapatra P, Ghosh A, Yadav R, Dodia H, Ansari SA, De S, Singh D, Suryawanshi A, Dash R, Senapati S, Beuria TK, Chattopadhyay S, Syed GH, Swain R, Raghav SK, Parida A. Long-read 16S-seq reveals nasopharynx microbial dysbiosis and enrichment of Mycobacterium and Mycoplasma in COVID-19 patients: a potential source of co-infection. Mol Omics. 2022, 18: 490-505.
  13. Singh B, Avula K, Chatterjee S, Datey A, Ghosh A, De S, Keshry SS, Ghosh S, Suryawanshi AR, Dash R, Senapati S, Beuria TK, Prasad P, Raghav SK, Swain R, Parida A, Hussain Syed G*, Chattopadhyay S*. Isolation and Characterization of Five Severe Acute Respiratory Syndrome Coronavirus 2 Strains of Different Clades and Lineages Circulating in Eastern India. Front Microbiol. 2022, 13: 856913.
  14. Ghosh A, Walia S, Rattan R, Kanampalliwar A, Jha A, Aggarwal S, Fatma S, Das N, Chayani N, Prasad P, Raghav SK*, Parida A. Genomic profiles of vaccine breakthrough SARS-CoV-2 strains from Odisha, India. Int J Infect Dis. 2022, 119: 111-113.
  15. Kemp SA, Cheng MTK, Hamilton WL, Kamelian K; Indian SARS-CoV-2 Genomics Consortium (INSACOG), Singh S, Rakshit P, Agrawal A, Illingworth CJR, Gupta RK*. Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers. Sci Rep. 2022, 12: 10492.
  16. Swain N, Tripathy A, Padhan P, Raghav SK, Gupta B. Toll-like receptor-7 activation in CD8+ T cells modulates inflammatory mediators in patients with rheumatoid arthritis. Rheumatol Int. 2022, 42: 1235-1245.
  17. Pathak AK, Mishra GP, Fatihi S, Abbas T, Uppili B, Ghosh A, Banu S, Bhoyar RC, Jain R, Divakar MK, Imran M, Faruq M, Sowpati DT, Thukral L, Raghav SK*, Mukerji M*. Spatio-temporal dynamics of intra-host variability in SARS-CoV-2 genomes. Nucleic Acid Research 2022, 50: 1551-1561.
  18. Chatterjee S, Datey A, Sengupta S, Ghosh A, Jha A, Walia S, Singh S, Suranjika S, Bhattacharya G, Laha E, Keshry SS, Ray A, Pani SS, Suryawanshi AR, Dash R, Senapati S, Beuria TK, Syed GH, Prasad P, Raghav SK, Devadas S, Swain RK, Chattopadhyay S, Parida A. Clinical, Virological, Immunological, and Genomic Characterization of Asymptomatic and Symptomatic Cases With SARS-CoV-2 Infection in India. Front Cell Infect Microbiol. 2021, 11: 725035.
  19. Sen K, Datta S, Ghosh A, Jha A, Ahad A, Chatterjee S, Suranjika S, Sengupta S, Bhattacharya G, Shriwas O, Avula K, Kshatri J, Prasad P, Swain R, Parida AK, Raghav SK*. Single-Cell Immunogenomic Approach Identified SARS-CoV-2 Protective Immune Signatures in Asymptomatic Direct Contacts of COVID-19 Cases. Front Immunol. 2021 12: 733539.
  20. Suresh V, Mohanty V, Avula K, Ghosh A, Singh B, Reddy RK, Parida D, Suryawanshi AR, Raghav SK, Chattopadhyay S, Prasad P, Swain RK, Dash R, Parida A, Syed GH, Senapati S*. Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host factors having implication in the disease pathogenesis and severity. FASEB J. 2021, 7: e21713.
  21. Choudhary HR, Parai D, Chandra Dash G, Kshatri JS, Mishra N, Choudhary PK, Pattnaik D, Panigrahi K, Behera S, Ranjan Sahoo N, Podder S, Mishra A, Raghav SK, Mishra SK, Pradhan SK, Sahoo SK, Pattnaik M, Rout UK, Nanda RR, Mondal N, Kanungo S, Palo SK, Bhattacharya D, Pati S. Persistence of Antibodies Against Spike Glycoprotein of SARS-CoV-2 in Healthcare Workers Post Double Dose of BBV-152 and AZD1222 Vaccines. Front Med (Lausanne). 2021, 8: 778129.
  22. Bhattacharya D, Choudhary HR, Parai D,  Dash GC, Kshatri JS, Mishra N, Choudhary PK, Pattnaik D, Panigrahi K, Behera S, Sahoo NR, Podder S, Mishra A, Raghav SK, Mishra SK, Pradhan SK, Sahoo SK, Pattnaik M, Rout UK, Ranjan R, Mondal N, Kanungo S, Palo SK, Pati S*. Persistence of antibodies against Spike glycoprotein of SARS-CoV-2 in health care workers post double dose of BBV-152 and AZD1222 vaccines. Frontiers in Medicine 2021, 8: 778129.
  23. Dhar MS, Marwal R, Vs R, Ponnusamy K, Jolly B, Bhoyar RC, Sardana V, Naushin S, Rophina M, Mellan TA, Mishra S, Whittaker C, Fatihi S, Datta M, Singh P, Sharma U, Ujjainiya R, Bhatheja N, Divakar MK, Singh MK, Imran M, Senthivel V, Maurya R, Jha N, Mehta P, A V, Sharma P, Vr A, Chaudhary U, Soni N, Thukral L, Flaxman S, Bhatt S, Pandey R, Dash D, Faruq M, Lall H, Gogia H, Madan P, Kulkarni S, Chauhan H, Sengupta S, Kabra S; Indian SARS-CoV-2 Genomics Consortium (INSACOG)‡, Gupta RK, Singh SK, Agrawal A, Rakshit P, Nandicoori V, Tallapaka KB, Sowpati DT, Thangaraj K, Bashyam MD, Dalal A, Sivasubbu S, Scaria V, Parida A, Raghav SK, Prasad P, Sarin A, Mayor S, Ramakrishnan U, Palakodeti D, Seshasayee ASN, Bhat M, Shouche Y, Pillai A, Dikid T, Das S, Maitra A, Chinnaswamy S, Biswas NK, Desai AS, Pattabiraman C, Manjunatha MV, Mani RS, Arunachal Udupi G, Abraham P, Atul PV, Cherian SS*. Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India. 2021, 374: 995-999.
  24. Mlcochova P, Kemp SA, Dhar MS, Papa G, Meng B, Ferreira IATM, Datir R, Collier DA, Albecka A, Singh S, Pandey R, Brown J, Zhou J, Goonawardane N, Mishra S, Whittaker C, Mellan T, Marwal R, Datta M, Sengupta S, Ponnusamy K, Radhakrishnan VS, Abdullahi A, Charles O, Chattopadhyay P, Devi P, Caputo D, Peacock T, Wattal C, Goel N, Satwik A, Vaishya R, Agarwal M; Indian SARS-CoV-2 Genomics Consortium (INSACOG); Genotype to Phenotype Japan (G2P-Japan) Consortium; CITIID-NIHR BioResource COVID-19 Collaboration, Mavousian A, Lee JH, Bassi J, Silacci-Fegni C, Saliba C, Pinto D, Irie T, Yoshida I, Hamilton WL, Sato K, Bhatt S, Flaxman S, James LC, Corti D, Piccoli L, Barclay WS, Rakshit P, Agrawal A, Gupta RK*. SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion. 2021, 599: 114-119.
  25. Borah NA, Sradhanjali S, Barik MR, Jha A, Tripathy D, Kaliki S, Rath S, Raghav SK, Patnaik S, Mittal R, Reddy MM. Aurora Kinase B Expression, Its Regulation and Therapeutic Targeting in Human Retinoblastoma. Invest Ophthalmol Vis Sci. 2021, 62: 16.
  26. Tripathy A, Padhan P, Swain N, Raghav SK, Gupta B. Increased Extracellular ATP in Plasma of Rheumatoid Arthritis Patients Activates CD8+T Cells. Arch Med Res. 2021, S0188-4409(21)00001-1.
  27. Dash P, Turuk J, Behera SK, Palo SK, Raghav SK*, Ghosh A, Sabat J, Rath S, Subhadra S, Rana K, Bhattacharya D, Kanungo S, Kshatri JS, Mishra BK, Dash S, Parida A, Pati S*. Sequence analysis of Indian SARS-CoV-2 isolates shows a stronger interaction of mutant receptor-binding domain with ACE2. Int J Infect Dis. 2021, 104: 491-500.
  28. Mohapatra P, Shriwas O, Mohanty S, Ghosh A, Smita S, Kaushik SR, Arya R, Rath R, Das Majumdar SK, Muduly DK, Raghav SK, Nanda RK, Dash R. CMTM6 drives cisplatin resistance by regulating Wnt signaling through the ENO-1/AKT/GSK3β axis. JCI Insight. 2021, 6: e143643.
  29. Smita S, Ghosh A, Biswas VK, Ahad A, Podder S, Jha A, Sen K, Acha-Orbea H, Raghav SK*. Zbtb10 transcription factor is crucial for murine cDC1 activation and cytokine secretion. Eur J Immunol. 2021 Feb 1.
  30. Raghav S*, Ghosh A, Turuk J, Kumar S, Jha A, Madhulika S, Priyadarshini M, Biswas VK, Shyamli PS, Singh B, Singh N, Singh D, Datey A, Avula K, Smita S, Sabat J, Bhattacharya D, Kshatri JS, Vasudevan D, Suryawanshi A, Dash R, Senapati S, Beuria TK, Swain R, Chattopadhyay S, Syed GH, Dixit A, Prasad P; Odisha COVID-19 Study Group; ILS COVID-19 Team, Pati S, Parida A. Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity. Front Microbiol. 2020, 11: 594928.
  31. Jaiswal KS, Khanna S, Ghosh A, Padhan P, Raghav SK, Gupta B. Differential mitochondrial genome in patients with Rheumatoid Arthritis. 2021, 54: 1-12.
  32. Ahad A, Smita S, Mishra GP, Biswas VK, Sen K, Gupta B, Garcin D, Acha-Orbea H, Raghav SK. NCoR1 fine-tunes type-I IFN response in cDC1 dendritic cells by directly regulating Myd88-IRF7 axis under TLR9. Eur J Immunol. 2020, 50: 1959-1975.
  33. Khanna S, Pradhan P, Jaiswal KS, Jain AP, Ghosh A, Tripathy A, Gowda H, Raghav SK, Gupta B. Altered mitochondrial proteome and functional dynamics in patients with rheumatoid arthritis. Mitochondrion 2020, 54:8-14.
  34. Das D, Das A, Sahu M, Mishra SS, Khan S, Bejugam PR, Rout PK, Das A, Bano S, Mishra GP, Raghav SK, Dixit A, Panda AC. Identification and characterization of circular intronic RNAs derived from insulin gene. International Journal of Molecular Sciences 2020, 21: 4302.
  35. Mishra GP, Ghosh A, Jha A, Raghav SK. BedSect: An integrated web server application to perform intersection, visualization and functional annotation of genomic regions from multiple datasets. Frontiers in Genetics 2020, 11: 3.
  36. Chen W, Schwalie PC, Pankevich EV, Gubelmann C, Raghav SK, Dainese R, Cassano M, Imbeault M, Jang SM, Russeil J, Delessa T, Duc J, Trono D, Wolfrum C, Deplancke B*. ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer. Nat Commun. 2019, 10: 1809.
  37. Ahad A, Stevanin M, Smita S, Mishra GP, Gupta D, Waszak S, Sarkar UA, Basak S, Gupta B, Acha-Orbea H, Raghav SK*. NCoR1: putting the brakes on the dendritic cell immune tolerance. iScience. 2019, 996-1011
  38. Smita S, Ahad A, Ghosh A, Biswas VK, Koga MM, Gupta B, Acha-Orbea H, Raghav SK. Importance of EMT Factor ZEB1 in cDC1 “MutuDC Line” Mediated Induction of Th1 Immune Response. Frontiers in Immunology 2018, 9: 2604.
  39. Jena KK, Kolapalli SP, Mehto S, Nath P, Das B, Sahoo PK, Ahad A, Syed GH, Raghav SK, Senapati S, Chauhan S, Chauhan S. TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. EMBO J. 2018, 37: e98358.
  40. Rib L, Villeneuve D, Minocha S, Praz V, Hernandez N, Guex N, Herr W; CycliX Consortium. Cycles of gene expression and genome response during mammalian tissue regeneration. Epigenetics Chromatin.2018, 11: 52.
  41. Tripathy A, Khanna S, Padhan P, Smita S, Raghav SK, Gupta B. Direct recognition of LPS drive TLR4 expressing CD8+ T cell activation in patients with rheumatoid arthritis. Sci Rep. 2017, 7: 933.
  42. Jonathan Aryeh Sobel, Irina Krier, Teemu Andersin, Sunil Raghav, Donatella Canella, Federica Gilardi, Alexandra Styliani Kalantzi, Guillaume Rey, Benjamin Weger, Frédéric Gachon, Matteo Dal Peraro, Nouria Hernandez, Ueli Schibler, Bart Deplancke, Felix Naef, and the CycliX consortium. Transcriptional regulatory logic of the diurnal cycle in the mouse liver. PLoS Biology 2017, 15: e2001069.
  43. Rachana Pradhan, Johannes Bues, Vincent Gardeux, Petra C. Schwalie, Daniel Alpern, Wanze Chen, Julie Russeil, Sunil Raghav, and Bart Deplancke. Dissecting the brown adipogenic regulatory network using integrative genomics. Scientific Reports 2017, 7:42130.
  44. Raghav SK, Gupta B*. Single cell Transcriptomics for autoimmune disorders.  J Mol Genet Med 2015, 9: 191.
  45. Sahu D, Raghav SK, Gautam H, Das HR. A novel coumarin derivative, 8-methoxy chromen-2-one alleviates collagen induced arthritis by down regulating nitric oxide, NFκB and proinflammatory cytokines. Immunopharmacol. 2015, 29, 891-900.
  46. Jain S, Suklabaidya S, Das B, Raghav SK, Batra SK, Senapati S. TLR4 activation by lipopolysaccharide confers survival advantage to growth factor deprived prostate cancer cells. 2015, 75:1020-1033.
  47. Waszak SM, Delaneau O, Gschwind AR, Kilpinen H, Raghav SK, Witwicki RM, Orioli A, Wiederkehr M, Panousis NI, Yurovsky A, Romano-Palumbo L, Planchon A, Bielser D, Padioleau I, Udin G, Thurnheer S, Hacker D, Hernandez N, Reymond A, Deplancke B, Dermitzakis ET. Population Variation and Genetic Control of Modular Chromatin Architecture in Humans. Cell 2015, 27: 1039-50.
  48. Gilardi F, Migliavacca E, Naldi A, Baruchet M, Canella D, Le Martelot G, Guex N, Desvergne B; CycliX Consortium. Genome-wide analysis of SREBP1 activity around the clock reveals its combined dependency on nutrient and circadian signals. PLoS Genet. 2014, 10: e1004155.
  49. Gubelmann C, Schwalie PC, Raghav SK, Röder E, Delessa T, Kiehlmann E, Waszak SM, Corsinotti A, Udin G, Holcombe W, Rudofsky G, Trono D, Wolfrum C, Deplancke B. Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network. 2014: e03346.
  50. Waszak SM, Kilpinen H, Gschwind AR, Orioli A, Raghav SK, Witwicki RM, Migliavacca E, Yurovsky A, Lappalainen T, Hernandez N, Reymond A, Dermitzakis ET, Deplancke B. Identification and removal of low-complexity sites in allele-specific analysis of ChIP-seq data. 2014, 30: 165-171.
  51. Kilpinen H, Waszak SM, Gschwind A, Raghav SK, Witwicki RM, Orioli A, Migliavacca E, Wiederkehr M, Gutierrez-Arcelus M, Panousis N, Yurovsky A, Lappalainen Tuuli, Romano-Palumbo L, Planchon A, Bielser D, Bryois J, Padioleau I, Udin G, Thurnheer S, Hacker D, Core LJ, Lis JT, Hernandez N, Reymond A, Deplancke B, Dermitzakis ET. Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription. Science 2013, 342: 744-747.
  52. Gubelmann C, Waszak SM, Isakova A, Holcombe W, Hens K, Iagovitina A, Feuz JD, Raghav SK, Simicevic J, Deplancke B. A yeast one-hybrid and microfluidics-based pipeline to map mammalian gene regulatory networks. Molecular Systems Biology 2013, 6; 9:682.
  53. Hawkins RD*, Larjo A, Tripathi SK, Wagner U, Luu Y, Loneberg T, Raghav SK, Lee LK, Lund R, Lähdesmäki H*, Ren B*, Lahesmaa R* Global chromatin state analysis reveals lineage-specific enhancers during early cell fate specification of human Th1 and Th2 cells. Immunity 2013, 38:1271-1284.
  54. Simicevic J, Schmid AW, Gilardoni P, Zoller B, Raghav SK, Krier I, Gubelmann C, Lisacek F, Naef F, Moniatte M, Lisacek F, Deplancke B. Absolute copy number analysis of transcription factors during cellular differentiation using a multiplex, targeted proteomics approach. Nature Methods 2013, 10: 570-576.
  55. LeMartelot G, Canella D, Symul L, Migliavacca E, Gilardi F, Liechti R, Martin O, Harshman K, Delorenzi M, Desvergne B, Herr W, Deplancke B, Schibler U, Rougemont J, Guex N, Hernandez N*, Naef F*, and CycliX consortium including Raghav SK. Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during circadian cycles. PLoS Biology 2012, 10: e1001442.
  56. Raghav SK, Waszak MS, Krier I, Gubelmann C, Mikkelsen ST, Deplancke B*. Integrative genomics identifies SMRT a gatekeeper of early adipogenesis through transcription factors C/EBPβ and KAISO. Molecular Cell 2012, 46, 335–350.
  57. Bernasconi D, Canella D, Gilardi F, LeMartelot GL, Praz V, Migliavacca E, Delorenzi M, Hernandez N*, and CycliX consortium including Raghav SK. A Multiplicity of Factors Contributes to Selective Transcription of a Subset of RNA polymerase III Genes in Mouse Liver. Genome Research 2012, 22: 666-680.
  58. Baitsch L, Baumgaertner P, Devêvre E, Raghav SK, Legat A, Barba L, Wieckowski S, Bouzourene H, Deplancke B, Romero P, Rufer N, Speiser DE*. Exhaustion of human self/tumor-specific CD8 T-cells in melanoma metastases. Journal of Clinical Investigation 2011, 121: 2350-60.
  59. Elo LL, Järvenpää H, Tuomela S, Raghav SK, Ahlfors H, Laurila K, Gupta B, Lund RJ, Tahvanainen J, Hawkins RD, Orešič M, Lähdesmäki H, Rasool O, Rao KV, Aittokallio T, Lahesmaa R*. IL-4 and STAT6-mediated transcriptional regulation to initiate Th2 program in human T cells. Immunity 2010, 6: 852-862.
  60. Laajala TD, Raghav S, Tuomela S, Lahesmaa R, Aittokallio T, Elo LL*. A practical comparison of methods for detecting transcription factor binding sites in ChIP-seq experiments. BMC Genomics, 2009, 18: 618.
  61. Rautajoki KJ, Kyläniemi MK, Raghav SK, Rao K, Lahesmaa R*. An insight into molecular mechanisms of human T helper cell differentiation. Annals of Medicine 2008, 40: 322-35.
  62. Gupta B, Raghav SK, Das HR*. S-Nitrosylation of mannose binding lectin regulates its functional activities and the formation of autoantibody in rheumatoid arthritis. Nitric oxide: Biology and Chemistry 2008, 18: 266-273.
  63. Raghav SK, Gupta B, Das HR*. Inhibition of lipopolysaccharide inducible iNOS and IL-1b expression by active compounds isolated from Ruta graveolens L. through suppression of NF-kB activation in murine macrophages. European Journal of Pharmacology 2007, 560: 69-80.
  64. Raghav SK, Gupta B, Agrawal C, Chaturvedi VP, Das HR*. Expression of TNF-a and related signaling molecules in the peripheral blood mononuclear cells of rheumatoid arthritis patients. Mediators of Inflammation 2006, 12682: 1-6.
  65. Raghav SK, Gupta B, Agrawal C, Saroha A, Das RH, Chaturvedi VP, Das HR*. Altered expression and glycosylation of plasma proteins in rheumatoid arthritis. Glycoconjugate Journal 2006, 23: 169-175.
  66. Raghav SK, Gupta B, Agrawal C, Goswami K, Das HR*. Anti-inflammatory effect of Ruta graveolens L. in murine macrophage cells. Journal of Ethnopharmacology 2006, 104: 234-239.
  67. Gupta B, Raghav SK, Agrawal C, Das RH, Chaturvedi VP, Das HR*. Anti-MBL autoantibodies in patients with rheumatoid arthritis: prevalence and clinical significance. Journal of Autoimmunity 2006, 27: 125-133.
  68. Chaudhury I, Raghav SK, Gautam H, Das HR, Das RH*. Suppression of inducible nitric oxide synthase by 10-23 DNAzymes in murine macrophages. FEBS Letters 2006, 580: 2046-2052.
  69. Gupta B, Agrawal C, Raghav SK, Das SK, Das RH, Chaturvedi VP, Das HR*. Association of mannose-binding lectin gene (MBL2) polymorphisms with rheumatoid arthritis in an Indian cohort of case-control samples. Journal of Human Genetics 2005, 50: 583–591.
  70. Agrawal C, Raghav SK, Gupta B, Das RH, Chaturvedi VP, Goswami K, Das HR*. Tumor necrosis factor-alpha microsatellite polymorphism association with rheumatoid arthritis in Indian patients. Archives of Medical Research 2005, 36: 555-559.
    1. Expanding research horizons abroad, annual magazine of Turku University, 2008.
    2. Genetic variability of SARS-CoV-2 strains and its impact on virus transmission, Atimukta Jha & Sunil K. Raghav, 2021.Article in University magazine / Science Horizon magazine

  2. Book Chapters / Article in University magazine / Science Horizon magazine

    1. Das HR*, Raghav S, Gupta B and Das RH. Anti-inflammatory compounds from medicinal plant Ruta graveolens. Acta Horticulture 2007, 756: 389- 398.
    2. Raghav SK, Deplancke B*. Genome-wide profiling of DNA binding proteins using barcode-based multiplex Solexa sequencing. Methods in Molecular Biology 2012, 786: 247-62.
    3. Expanding research horizons abroad, annual magazine of Turku University, 2008.
    4. Genetic variability of SARS-CoV-2 strains and its impact on virus transmission, Atimukta Jha & Sunil K. Raghav, 2021.

  3. Patents Filed / granted:

    1. Method for the diagnosis of rheumatoid arthritis. Hasi Das, Bhawna Gupta, Sunil Kumar Raghav, Kalyan Goswami, Charu Agrawal and Rakha Hari Das. IPC8 Class: AG01N3353FI, US Patent 7,763,436.
    2. Novel anti-inflammatory compound 3-(1,1-dimethyl-allyl)-6-hydroxy-chromen-2-one isolated from Ruta graveolens L. Hasi Das, Sunil Kumar Raghav, Bhawna Gupta. IPC8 Class: AA61K31352FI, US Patent App. 11/935,985.
    3. Novel diagnostic marker, a diagnostic kit and a method for diagnosis of rheumatoid arthritis. Hasi Das, Bhawna Gupta, Sunil Kumar Raghav, Kalyan Goswami, Charu Agrawal and Rakha Hari Das. US Patent App. 11/281,243.

Group

Details

Sreeparna Podder, Project JRF

Project: Role of NCoR1 in DC differentiation

Subhasis Prusty, JRF

Project: NCoR1 mediated metabolic control of Mtb pathogenesis

Sudeshna Dutta, ICMR SRF

Project: Tribal population genetics, Single cell genomics

Aishwarya Sen, SRF

Project: Role of non-coding RNA in dendritic cell function

Chayan Mukhejee, DBT JRF

Project: Single cell approach to dilineate Cross talk of TLR mediated signaling in Dendritic cells
Mamuni Swain, Technician

Lab Alumni:

Dr. Abdul Ahad, Alumni (Currently postdoc at NCI-NIH)
Dr. Shuchi Smita, Alumni (Currently Senior Investigator in Syngene, Bristol Myiers, Bangalore)
Safal Walia, Data analyst (Graduate student at Munich, Germany)
Dr. Atimukta Jha, (Currently Postdoc at Cornell University, USA)

Dr. Arup Ghosh, (Currently Project Scientist-C at NIRTH, Jabalpur)

Dr. Gyan Prakash Mishra (Currently postdoc in USA)

Viplov K. Biswas, (Currently Postdoc in USA)

Dr. Kaushik Sen, (Just completed her PhD, looking for suitable postdoc position)
Sudershana Jena, (Former technician in Lab)

Open positions in group:

IMGSB group is always looking for research passionate Masters dissertation students (6 months to one year project), with a strong interest in the field of immunology, Genomics and Systems Biology. Prior exposure in common laboratory techniques such as cell culture, western blotting.

The group has always an open position for computational biology students (Masters students, PhD students and postdocs) with good programming skills especially using R, Perl / Python, and Linux for NGS data analysis.

If you are really interested to live research in reality, write to Dr. Sunil K. Raghav at raghuvanshi2010@yahoo.co.in, sunil.raghav@ils.res.in with a small summary describing your research interests along with a detailed CV.

Grants

Details

Completed grants:

  1. DBT Ramalingaswami fellowship: 2013-2018
  2. DST SNSF Indo-Swiss grant: 2015-2018
  3. SERB: Integrative genomics to identify the role of zinc finger transcription factors ZEB1 and ZEB2 in dendritic cells and impact on T helper cell differentiation, (2016-2019)
  4. DBT: Identify the role of coregulators in dendritic cell responses and its impact on T helper cell differentiation, (2017-2020)
  5. SERB: ZBTB10: a potential trigger for dendritic cell immune responses, (2020-2023)

Ongoing extra-mural grants:

DBT:  INSACOG consortium (Since January 2022)

DBT: GenomeIndia Initiative: cataloguing the genetic variation in Indians. (Since January 2020)

DBT:  ILS flagship programme on multiomics studies to uplift Odisha tribal health and nutrition (Since 2019)

Contacts

EmailAddressFaxOffice
sunilraghav@ils.res.inlab-3 , Immuno-Genomics and Systems Biology Group, Institute of Life Sciences, Nalco Square, Bhubaneswar-751023, India +91 674 2304310 (Office)

Highlights

Details
  • Best wished and congratulations to Gyan, Atimukta, Kaushik and Arup for completeing their PhD degree with remarkable publications in the field.
  • Congratulations to Kaushik for the amazing DC metabolism work recently published in Redox Biology journal.
  • Congratulations to Atimukta and team for manuscript accepted in Frontiers in Immunology.
  • Warm welcome to Mr. Chayan Mukherjee for joining IMGSB group as a graduate student.
  • Congratulations to Gyan and team for comparative epigenomics paper accepted in Cellular and Molecular Life Sciences.
  • Congratulations to the IMGSB team for working so efficiently on different COVID related projects and publishing the important scientific findings in hard times.
  • Congratulations to Abdul and Shuchi for defending their thesis and being the flag bearers of the lab in finishing PhD line. Also congrats to them as they have the postdoc positions in hand just after finishing their PhD.
  • Welcome to new IMGSB members Sudeshna Dutta and Safal Walia as data analyst to work on Genome India project.
  • Welcome to new Ph.D. students Ms. Aishwarya Sen and  Mr. Subhasis Prusty to the IMGSB group.
  • Congratulations to Shuchi who recently got a travel grant to attend Keystone conference in Cape-town Africa from 08th-12th December 2019.
  • Congratulations to Gyan in the lab who recently got a travel grant to attend the EMBL conference in Australia from 24th-28th November 2019.
  • Congratulations to Abdul and colleagues in IMGSB group who has recently identified that NCoR1 is a master regulator of dendritic cell immunogenic function and the study is published in iScience, 2019.
  • Congratulations to Shuchi and colleagues in IMGSB group who has recently identified that Zeb1 depletion can induce strong Th2 responses and can help in clearing helminth infection and the study is published in Frontiers of Immunology, 2018.
  • We warmly welcome Prof Hans Acha-Orbea from UNIL, Lausanne, Switzerland for Sabbatical work in our laboratory at ILS for six months from December 2016 to July 2017.
  • Prof. Hans Acha-Orbea and his lab members from UNIL, Lausanne, Switzerland visited our lab in march 2016 in the purview of DST-SNSF Indo-Swiss project.
  • Dr. Sebastian M. Waszak, Senior Postdoc at EMBL, Heidelberg visited our group from 5th-08th Dec, 2015. He gave a guest lecture at ILS. The group had close discussion with him on several projects and for future collaborations.

Positions

Details

IMGSB lab is always looking for research passionate students who are interested in deep understanding of the immune response development.

If you have that interest drop an email to sunilraghav@ils.res.in with a statement of interest and your CV in a single PDF. Lab is ready to sponsor the applications for the DBT Research associate and Women scientist positions if interested.

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