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Dr. Soma Chattopadhyay


Degree University/Institution
M.Sc. in ZoologyUniversity of Calcutta
Ph.D. (Molecular Virology of Human Rotaviruses)University of Calcutta [National Institute of Cholera and Enteric Diseases (NICED), Kolkata]

Work Experience

Position University/Organisation Period
Scientist FInstitute of Life Sciences, Bhubaneswar-751023, India.Since July 2021
Scientist EInstitute of Life Sciences, Bhubaneswar-751023, India.July 2017 to June 2021
Scientist DInstitute of Life Sciences, Bhubaneswar-751023, India.July 2013 to June 2017
Scientist CInstitute of Life Sciences, Bhubaneswar-751023, India.October 2007 to June 2013
Post-Doctoral FellowshipUniversity of Connecticut Health Center, Farmington, USA.2003-2007
Senior Research FellowshipCSIR2001-2003
Junior Research FellowshipICMR (National Institute of Cholera & Enteric Diseases, Kolkata)2001
Junior Research FellowshipDBT (National Institute of Cholera & Enteric Diseases, Kolkata)1998-2001

Awards & Recognition

  • Life member, Society of Biological Chemists (India).
  • Life member, Indian Virological Society
  • Life member, Proteomics society of India



Molecular Virology

Broad Research Interest: Molecular virology: Viral replication, Virus-Cell interactions, Pathogenesis of Viral infection, Regulation of Viral Infection

Research projects

Chikungunya Infection:

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes a disease syndrome characterized by fever, headache, rash, nausea, vomiting, myalgia and arthralgia. According to the posture developed as a result of the arthritic symptoms of the disease the name is derived from the Makonde word meaning “that which bends up”.

The disease was first described in 1952 in Tanzania, Africa and is geographically distributed from Africa through Southeast Asia and South America. After a gap of 32 years, re-emergence of Chikungunya virus caused recent outbreaks in India during 2005-2006 affecting 1.3 million people in 13 states. Due to recent extension around the Indian Ocean, including Comoros, Mauritius, Reunion Island, Madagascar and now in Italy, Chikungunya is regarded as a potential worldwide public health problem with no preventive or therapeutic means available. This establishes the need to improve disease surveillance, study the pathogenesis and biology of the virus.

The alpha viruses are enveloped particles and their genome consists of a linear, single- stranded, positive sense RNA molecule of approximately 11.8 kb. CHIK V genome encodes four non-structural proteins (NSP1-4) and three main structural proteins (C, E1, and E2). The non-structural proteins which are generally required for viral replication are encoded in the 5’ two-third of the genome. These proteins might have some role in modulating the host protein synthesis for the advantage of the viral infection as well as for pathogenesis or virulence.

Due to lack of research on the Chikungunya viral biology the precise role of the non-structural proteins and the host factors are not yet understood. The knowledge about viral replication and host cell factors will be useful to understand the process of disease progression and find out ways to develop an effective antiviral therapy.

Thus, my laboratory is working on the following topics :

  • Define the functions of the non-structural proteins of Chikungunya virus during replication.
  • Understand the structure-function relationship of important viral enzymes which can be target for antiviral drugs.
  • Identify the cellular proteins required for viral life cycle.
  • Understand the molecular mechanism of disease progression and identify the pathogenic marker to modulate the disease developed by Chikungunya.





  1. Chatterjee, S., Kumar, S., Mamidi, P., Datey, A., Sengupta, S., Mahish, C., Laha, E., De, S., Keshry, S. S., Nayak, T. K., Ghosh, S., Singh, S., Subudhi, B. B., Chattopadhyay, S., & Chattopadhyay, S. (2022). DNA Damage Response Signaling Is Crucial for Effective Chikungunya Virus Replication. Journal of virology
  2. Chatterjee, S., Keshry, S. S., Ghosh, S., Ray, A., & Chattopadhyay, S #. (2022). Versatile β-Catenin Is Crucial for SARS-CoV-2 Infection. Microbiology spectrum
  3. De S, Ghosh S, Keshry SS, Mahish C, Mohapatra C, Guru A, Mamidi P, Datey A, Pani SS, Vasudevan D, Beuria TK, Chattopadhyay S, Subudhi BB #, Chattopadhyay S #. MBZM-N-IBT, a Novel Small Molecule, Restricts Chikungunya Virus Infection by Targeting nsP2 Protease Activity In Vitro, In Vivo, and Ex Vivo. Antimicrobial Agents and Chemotherapy. 2022
  4. Singh B, Avula K, Chatterjee S, Datey A, Ghosh A, De S, Keshry SS, Ghosh S, Suryawanshi AR, Dash R, Senapati S, Beuria TK, Prasad P, Raghav S, Swain R, Parida A, Hussain Syed G #, Chattopadhyay S #. Isolation and Characterization of Five Severe Acute Respiratory Syndrome Coronavirus 2 Strains of Different Clades and Lineages Circulating in Eastern India. Frontiers in Microbiology. 2022
  5. Simo Nemg FB, De S, Keshry SS, Mamidi P, Njayou FN, Demanou M, Moundipa Fewou P #, Chattopadhyay S #. Plants extracts from Cameroon pharmacopeia strongly inhibit the Chikungunya virus infection by targeting entry and replication steps. Journal of Ethnopharmacology. 2022
  6. Prasad P #, Mahapatra S, Mishra R, Murmu KC, Aggarwal S, Sethi M, Mohapatra P, Ghosh A, Yadav R, Dodia H, Ansari SA, De S, Singh D, Suryawanshi A, Dash R, Senapati S, Beuria TK, Chattopadhyay S, Syed GH, Swain R, Raghav SK, Parida A #. Long-read 16S-seq reveals nasopharynx microbial dysbiosis and enrichment of Mycobacterium and Mycoplasma in COVID-19 patients: a potential source of co-infection. Molecular Omics. 2022
  7. Sengupta S, Bhattacharya G, Chatterjee S, Datey A, Shaw SK, Suranjika S, Nath P, Barik PK, Prasad P, Chattopadhyay S, Swain RK, Parida A #, Devadas S #. Underlying Co-Morbidity Reveals Unique Immune Signatures in Type II Diabetes Patients Infected With SARS-CoV2. Frontiers in Immunology. 2022
  8. Panda S K, Mishra S, Mamidi P, Chattopadhyay S, Singh A K #. An efficient PET-based probe for detection and discrimination of Zn2+ and Cd2+ in near-aqueous media and live-cell imaging. Journal of Photochemistry and Photobiology A: Chemistry. 2022
  9. De S, Mamidi P, Ghosh S, Keshry SS, Mahish C, Pani SS, Laha E, Ray A, Datey A, Chatterjee S, Singh S, Mukherjee T, Khamaru S, Chattopadhyay S #, Subudhi BB #, Chattopadhyay S #. Telmisartan Restricts Chikungunya Virus Infection In Vitro and In Vivo through the AT1/PPAR-γ/MAPKs Pathways. Antimicrobial Agents and Chemotherapy. 2022


  1. Chatterjee S, Datey A, Sengupta S, Ghosh A, Jha A, Walia S, Singh S, Suranjika S, Bhattacharya G, Laha E, Keshry SS, Ray A, Pani SS, Suryawanshi AR, Dash R, Senapati S, Beuria TK, Syed GH, Prasad P, Raghav SK, Devadas S, Swain RK, Chattopadhyay S, Parida A. Clinical, Virological, Immunological, and Genomic Characterization of Asymptomatic and Symptomatic Cases With SARS-CoV-2 Infection in India. Frontiers in Cellular and Infection Microbiology. 2021
  2. Mamidi P, Nayak TK, Kumar A, Kumar S, Chatterjee S, De S, Datey A, Ghosh S, Keshry SS, Singh S, Laha E, Ray A, Chattopadhyay S, Chattopadhyay S. MK2a inhibitor CMPD1 abrogates chikungunya virus infection by modulating actin remodeling pathway. PLoS Pathogens. 2021
  3. Nath P, Chauhan NR, Jena KK, Datey A, Kumar ND, Mehto S, De S, Nayak TK, Priyadarsini S, Rout K, Bal R, Murmu KC, Kalia M, Patnaik S, Prasad P, Reggiori F, Chattopadhyay S, Chauhan S. Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses. EMBO Reports. 2021
  4. Kumar A, De S, Moharana AK, Nayak TK, Saswat T, Datey A, Mamidi P, Mishra P, Subudhi BB, Chattopadhyay S. Inhibition of herpes simplex virus-1 infection by MBZM-N-IBT: in silico and in vitro studies. Virology Journal. 2021


  1. Hossain S, Prakash V, Mamidi P, Chattopadhyay S, Singh A. Pyrene Appended Bipyridine Hydrazone Ligand as a Turn-ON Sensor for Cu2+ and Its Bioimaging Application. RSC Advances. 2020
  2. Datey A, Singh LM, Rajkhowa U, Prusty BK, Saswat T, Mamidi P, Barkalita LM, Dutta R, Sharma KC, Sahoo D, Borah P, Devi SI, Chattopadhyay S. Molecular epidemiology of Japanese encephalitis virus in pig population of Odisha, Assam and Manipur states of India. Infection, Genetics and Evolution. 2020
  3. Sanjai Kumar P, Nayak TK, Mahish C, Sahoo SS, Radhakrishnan A, De S, Datey A, Sahu RP, Goswami C, Chattopadhyay S, Chattopadhyay S. Inhibition of transient receptor potential vanilloid 1 (TRPV1) channel regulates chikungunya virus infection in macrophages. Archives of Virology. 2020
  4. Jena KK, Mehto S, Nath P, Chauhan NR, Sahu R, Dhar K, Das SK, Kolapalli SP, Murmu KC, Jain A, Krishna S, Sahoo BS, Chattopadhyay S, Rusten TE, Prasad P, Chauhan S, Chauhan S. Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response. EMBO Reports. 2020
  5. Raghav S, Ghosh A, Turuk J, Kumar S, Jha A, Madhulika S, Priyadarshini M, Biswas VK, Shyamli PS, Singh B, Singh N, Singh D, Datey A, Avula K, Smita S, Sabat J, Bhattacharya D, Kshatri JS, Vasudevan D, Suryawanshi A, Dash R, Senapati S, Beuria TK, Swain R, Chattopadhyay S, Syed GH, Dixit A, Prasad P; Odisha COVID-19 Study Group; ILS COVID-19 Team, Pati S, Parida A. Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus InfectivityFrontiers in Microbiology. 2020


  1. Dey D, Siddiqui SI, Mamidi P, Ghosh S, Kumar CS, Chattopadhyay S, Ghosh S, Banerjee M. The effect of amantadine on an ion channel protein from Chikungunyavirus. PLOS Neglected Tropical Diseases. 2019
  2. Nayak TK, Mamidi P, Sahoo SS, Kumar PS, Mahish C, Chatterjee S, Subudhi BB, Chattopadhyay S, Chattopadhyay S. P38 and JNK Mitogen-Activated Protein Kinases Interact with Chikungunya Virus Non-Structural Protein-2 and Regulate TNF Induction during Viral Infection in Macrophages. Frontiers in Immunology. 2019
  3. Saswat T, Sahoo N, Muduli S, Debata NK, Chattopadhyay S, Chattopadhyay S. Epidemiological trends and molecular dynamics of dengue, chikungunya virus infection, coinfection, and other undifferentiated fever during 2015-2016 in Odisha, India. Journal of Medical Virology. 2019
  4. Patro ARK, Mohanty S, Prusty BK, Singh DK, Gaikwad S, Saswat T, Chattopadhyay S, Das BK, Tripathy R, Ravindran B. Cytokine Signature Associated with Disease Severity in Dengue. Viruses. 2019


  1. Kumar S, Kumar A, Mamidi P, Tiwari A, Kumar S, Mayavannan A, Mudulli S, Singh AK, Subudhi BB, Chattopadhyay S. Chikungunya virus nsP1 interacts directly with nsP2 and modulates its ATPase activity. Scientific Reports. 2018


  1. Nayak TK, Mamidi P, Kumar A, Singh LP, Sahoo SS, Chattopadhyay S, Chattopadhyay S. Regulation of Viral Replication, Apoptosis and Pro-Inflammatory Responses by 17-AAG during Chikungunya Virus Infection in MacrophagesViruses. 2017


  1. Mishra P, Kumar A, Mamidi P, Kumar S, Basantray I, Saswat T, Das I, Nayak TK, Subhasis Chattopadhyay S, Subudhi BB, Chattopadhyay S. Inhibition of Chikungunya Virus Replication by 1-[(2-Methylbenzimidazol-1-yl) Methyl]-2-Oxo Indolin-3-ylidene] Amino] Thiourea (MBZM-N-IBT). Scientific Reports.2016


  1. Kumar S, Mamidi P, Kumar A, Basantray I, Bramha U, Dixit A, Maiti PK, Singh S, Suryawanshi AR, Chattopadhyay S, Chattopadhyay S. Development of novel antibodies against non-structural proteins nsP1, nsP3 and nsP4 of Chikungunya virus: Potential use in basic researchArchives of Virology. 2015
  2. Saswat T, Kumar A, Kumar S, Mamidi P, Muduli S, Debata NK, Pal NS, Pratheek BM., Chattopadhyay S, Chattopadhyay S. High rates of co-infection of Dengue and Chikungunya virus in Odisha and Maharashtra, India during 2013Infection, Genetics and Evolution. 2015
  3. Pratheek BM, Suryawanshi AR, Chattopadhyay S, Chattopadhyay S. In silico analysis of MHC-I restricted epitopes of Chikungunya virus proteins: Implication in understanding anti-CHIKV CD8(+) T cell response and advancement of epitope based immunotherapy for CHIKV infectionInfection, Genetics and Evolution. 2015


  1. Chattopadhyay S, Kumar A, Mamidi P, Nayak TK, Das I, Chhatai J, Basantray I, Bramha U, Maiti PK, Singh S, Suryawanshi AR, Chattopadhyay S. Development and characterization of monoclonal antibody against non-structural protein-2 of Chikungunya virus and its application. Journal of Virological Methods. 2014
  2. Kumar A, Mamidi P, Das I, Nayak TK, Kumar S, Chhatai J, Chattopadhyay S, Suryawanshi AR, Chattopadhyay S. A novel 2006 Indian outbreak strain of Chikungunya virus exhibits different pattern of infection as compared to prototype strain. PLOS One. 2014
  3. Das I, Basantray I, Mamidi P, Nayak TK, B M P, Chattopadhyay S, Chattopadhyay S. Heat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infection. PLOS One. 2014


  1. Chattopadhyay S, Weller SK. Direct interaction between the N- and C-terminal portions of the herpes simplex virus type 1 origin binding protein UL9 implies the formation of a head-to-tail dimer. Journal of Virology. 2007


  1. Chattopadhyay S, Weller SK. DNA binding activity of the herpes simplex virus type 1 origin binding protein, UL9, can be modulated by sequences in the N terminus: correlation between transdominance and DNA bindingJournal of Virology. 2006
  2. Varghese V, Ghosh S, Das S, Bhattacharya SK, Krishnan T, Karmakar P, Kobayashi N, Naik TN. Characterization of VP1, VP2 and VP3 gene segments of a human rotavirus closely related to porcine strains. Virus Genes. 2006


  1. Chaudhuri S, Das S, Chowdhury A, Santra A, Bhattacharya SK, Naik TN. Molecular epidemiology of HCV infection among acute and chronic liver disease patients in Kolkata, IndiaJournal of Clinical Virology. 2005


  1. Das S, Varghese V, Chaudhuri S, Barman P, Kojima K, Dutta P, Bhattacharya SK, Krishnan T, Kobayashi N, Naik TN. Genetic variability of human rotavirus strains isolated from Eastern and Northern India. Journal of Medical Virology. 2004
  2. Barman P, Ghosh S, Das S, Varghese V, Chaudhuri S, Sarkar S, Krishnan T, Bhattacharya SK, Chakrabarti A, Kobayashi N, Naik TN. Sequencing and sequence analysis of VP7 and NSP5 genes reveal emergence of a new genotype of bovine group B rotaviruses in India. Journal of Clinical Microbiology. 2004
  3. Varghese V, Das S, Singh NB, Kojima K, Bhattacharya SK, Krishnan T, Kobayashi N, Naik TN. Molecular characterization of a human rotavirus reveals porcine characteristics in most of the genes including VP6 and NSP4Archives of Virology. 2004


  1. Das S, Varghese V, Chaudhury S, Barman P, Mahapatra S, Kojima K, Bhattacharya SK, Krishnan T, Ratho RK, Chhotray GP, Phukan AC, Kobayashi N, Naik TN. Emergence of novel human group A rotavirus G12 strains in IndiaJournal of Clinical Microbiology. 2003


  1. Das S, Sen A, Uma G, Varghese V, Chaudhuri S, Bhattacharya SK, Krishnan T, Dutta P, Dutta D, Bhattacharya MK, Mitra U, Kobayashi N, Naik TN. Genomic diversity of group A rotavirus strains infecting humans in eastern IndiaJournal of Clinical Microbiology. 2002


  1. Sen A, Kobayashi N, Das S, Krishnan T, Bhattacharya SK, Naik TN. The evolution of human group B rotaviruses. The Lancet. 2001


  1. Sen A, Kobayashi N, Das S, Krishnan T, Bhattacharya SK, Urasawa S, Naik TN. Amplification of various genes of human group B rotavirus from stool specimens by RT-PCR. Journal of Clinical Virology. 2000


  1. Krishnan T, Sen A, Choudhury JS, Das S, Naik TN, Bhattacharya SK. Emergence of adult diarrhoea rotavirus in Calcutta, India. The Lancet. 1999

Review articles:

  1. Kumar, P. S., Radhakrishnan, A., Mukherjee, T., Khamaru, S., Chattopadhyay, S., & Chattopadhyay, S. (2022). Understanding the role of Ca2+ via transient receptor potential (TRP) channel in viral infection: Implications in developing future antiviral strategies. Virus research
  2. Subudhi BB, Chattopadhyay S, Chattopadhyay S. Targeting host factors of virus-induced inflammation: a strategy for tackling future epidemics by RNA viruses. Future Virology. 2022
  3. Translational Research Consortia (TRC) for Chikungunya Virus in India. Current Status of Chikungunya in India. Frontiers in Microbiology. 2021
  4. Subudhi BB, Chattopadhyay S, Mishra P, Kumar A. Current Strategies for Inhibition of Chikungunya Infection. Viruses. 2018
  5. Pratheek BM, Nayak TK, Sahoo SS, Mohanty PK, Chattopadhyay S, Chakraborty NG, Chattopadhyay S. Mammalian non-classical major histocompatibility complex I and its receptors: Important contexts of gene, evolution, and immunityIndian Journal of Human Genetics. 2014
  6. Pratheek BM, Saha S, Maiti PK, Chattopadhyay S, Chattopadhyay S. Immune regulation and evasion of Mammalian host cell immunity during viral infection. Indian Journal of Virology. 2013
  7. Chattopadhyay S, Chen Y, Weller SK. The two helicases of herpes simplex virus type 1 (HSV-1). Frontiers in Bioscience. 2006
  • Patents filed/granted:


  1. Patent No.: 347450; Priority Date: 12.12.2014; Grant date:19.09.2020. Chattopadhyay S, Kumar A, Subudhi BB, Mishra P. A composition for inhibition of infection caused by Chikungunya virus (CHIKV).


  1. Application No.: 202031033920. BB Subudhi, R N Dash, Alok Kumar Moharana, P Mamidi, S Chattopadhyay. Anti-CHIKV Ibuprofen conjugates and method of preparation thereof. Filing date: 07/08/2020.
  2. Application No.: 201931012926. BB Subudhi, R N Dash, T K Mohapatra, P Mamidi, S Chattopadhyay. Antiviral Drug Conjugate Composition. Filing Date: 30/03/2019.



Molecular Virology Group:

Dr. Mamidi Prabhudutta
Research Associate
Email ID:
Ms. Sanchari Chatterjee
Email ID:
Ms. Ankita Datey
Email ID:
Mr. Saikat De
Email ID:
Ms. Eshna Laha
Email ID:
Mrs. Amrita Ray
Email ID:
Ms. Supriya Suman Keshry
Email ID:
Mr. Sharad Singh
Email ID:
Mr. Soumyajit Ghosh
Email ID:

Mrs. Sweta Smita Pani
Research Assistant
Email ID:


Title of the Project Funding Agency Duration
Translational Research Consortia (TRC) for Chikungunya virus. BIRAC 4 Years (2019-2023)
Evaluation of Telmisartan and its combination with Chloroquine/ Ribavirin for management of Chikungunya virus infection. DBT 2 Years (2019-2021)
Identification of interacting host and vector partners for CHIKV nsP2 protein. DBT 3 Years (2018-2021)
Development of 1-[(2-methylbenzimidazol-1-yl) methyl]-2-oxo-indolin-3-ylidene] amino] thiourea (MBZM-N-IBT) as specific inhibitor of Chikungunya virus (MBZMNIBT) as specific inhibitor of Chikungunya virus. DBT 3 Years (2017-2020)
Study on persistence of Japanese Encephalitis in reservoir host, pig in endemic area of odisha, Manipur and Assam. IBSD 2 Years (2017-2019)
Development of Specific Inhibitor of Chikungunya Virus. DST 3 Years (2016-2019)
Identification and characterization of differentially expressed host proteins for both S-27 and DRDE-06 strains of Chikungunya virus in mouse model : Implications in understanding its epidemic potential. DST 3 Years (2016-2019)
Purification and biochemical characterization of the non-structural protein 3 (nsP3) of CHIKV. DST 3 years (2014-2017)
Analysis of cellular immune response of macrophages during experimental Chikungunya virus (CHIKV) infection. CSIR 3 years (2011-2014)
Differential Proteomics and genetics approach to reveal the cause of recent Chikungunya virus outbreak in India. DBT 3 years (2011-2014)
Studies on Chikungunya Virus infection: Role of non-structural protein-2 and cellular proteins. DBT 3 years (2010-2013)


sochat.ils@gmail.comInstitute of Life Sciences (ILS), Nalco Square, Bhubaneswar-751023, India0091 674 2300137/ 2301476/ 2301219, Ext. 235/ 2304235 (direct)