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Dr. Gunjan Mandal


Degree University/Institution
Ph.D. in Tumor Immunobiology, Biotechnology University of Calcutta
Masters in Science in ZoologyUniversity of Calcutta

Work Experience

Position University/Organisation Period
Scientist BDBT-Institute of Life Sciences, Bhubaneswar, Odisha, India2022 onwards
Postdoctoral FellowLaboratory of Systems Biology & Genetics, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.2021- 2022
Research Associate IIIH Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA2019-2020
Senior Research Fellow (UGC)Department of Zoology, University of Calcutta, Kolkata 2016-2019
Junior Research Fellow (UGC)Department of Zoology, University of Calcutta, Kolkata2014-2016
Junior Research Fellow (DST)Department of Zoology, University of Calcutta, Kolkata2013-2014

Awards & Recognition



Traditionally, tumor immunology has been chiefly centered on T lymphocytes, but T cells do not work alone. A coordinated humoral response with cellular arm of adaptive immunity develops robust and sustained effectiveness and long-term memory. Although, B lymphocytes have been correlated with cancer-promoting activities, recent evidence exhibit that humoral response is associated with immune protection in multiple cancers. The cross-talk of B lymphocytes with other immune cells at tumor beds, apart from T cells, is an area that needs to be thoroughly investigated. Germinal center formation in epithelial malignancies is a complex process that ensures production of protective anti-tumor antibodies at tumor beds, and we speculate that orchestration of tertiary-lymphoid-structures that eventually leads to germinal centers is largely dependent on non-B, non-T immune and non-immune cells. Utilizing the enduring knowledge in the field of cancer biology and tumor immunology, the long-term goal of the Mandal laboratory at DBT-Institute of Life Sciences is to build a comprehensive understanding of how the cells in the tumor microenvironment direct the nature of spontaneous immune pressure at different solid cancers within the tumor microenvironment, with a special focus on cancers that specifically affects women. The immediate aim of our lab is to holistically examine the impact of crosstalk between cancer cells and tumor-infiltrating lymphocytes and other immune cells in driving or dampening a sustained, robust anti-tumor immune response.





Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells. Anadon CM, Yu X, Hänggi K, Biswas S, Chaurio RA, Martin A, Payne KK, Mandal G, Innamarato P, Harro CM, Mine JA, Sprenger KB, Cortina C, Powers JJ, Costich TL, Perez BA, Gatenbee CD, Prabhakaran S, Marchion D, Heemskerk MHM, Curiel TJ, Anderson AR, Wenham RM, Rodriguez PC, Conejo-Garcia JR. Cancer Cell. 2022 May 9;40(5):545-557.e13. doi: 10.1016/j.ccell.2022.03.008. Epub 2022 Apr 14. PMID: 35427494.
IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer.  Mandal G, Biswas S, Anadon CM, Yu X, Gatenbee CD, Prabhakaran S, Payne KK, Chaurio RA, Martin A, Innamarato P, Moran C, Powers JJ, Harro CM, Mine JA, Sprenger KB, Rigolizzo KE, Wang X, Curiel TJ, Rodriguez PC, Anderson AR, Saglam O, Conejo-Garcia JR. Cancer Research. 2022 Mar 1;82(5):859-871. doi: 10.1158/0008- 5472.CAN-21-2376. PMID: 34949671.
TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures.Chaurio RA, Anadon CM, Lee Costich T, Payne KK, Biswas S, Harro CM, Moran C, Ortiz AC, Cortina C, Rigolizzo KE, Sprenger KB, Mine JA, Innamarato P, Mandal G, Powers JJ, Martin A, Wang Z, Mehta S, Perez BA, Li R, Robinson J, Kroeger JL, Curiel TJ, Yu X, Rodriguez PC, Conejo-Garcia JR. Immunity. 2022 Jan 11;55(1):115-128.e9. doi: 10.1016/j.immuni.2021.12.007. PMID: 35021053.
IgA transcytosis and antigen recognition govern ovarian cancer immunity.Biswas S, Mandal G, Payne KK, Anadon CM, Gatenbee CD, Chaurio RA, Costich TL, Moran C, Harro CM, Rigolizzo KE, Mine JA, Trillo- Tinoco J, Sasamoto N, Terry KL, Marchion D, Buras A, Wenham RM, Yu X, Townsend MK, Tworoger SS, Rodriguez PC, Anderson AR, Conejo-Garcia JR. Nature. 2021 Mar;591(7850):464-470. doi: 10.1038/s41586- 020-03144-0. Epub 2021 Feb 3. PMID: 33536615.
Methyltransferase inhibitors restore SATB1 protective activity against cutaneous T cell lymphoma in mice.Harro CM, Perez-Sanz J, Costich TL, Payne KK, Anadon CM, Chaurio RA, Biswas S, Mandal G, Rigolizzo KE, Sprenger KB, Mine JA, Showe LC, Yu X, Liu K, Rodriguez PC, Pinilla-Ibarz J, Sokol L, Conejo-Garcia JR. Journal of Clinical Investigation. 2021 Feb 1;131(3). doi: 10.1172/JCI135711. PMID: 33270606.
BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells. Payne KK, Mine JA, Biswas S, Chaurio RA, Perales-Puchalt A, Anadon CM, Costich TL, Harro CM, Walrath J, Ming Q, Tcyganov E, Buras AL, Rigolizzo KE, Mandal G, Lajoie J, Ophir M, Tchou J, Marchion D, Luca VC, Bobrowicz P, McLaughlin B, Eskiocak U, Schmidt M, Cubillos-Ruiz JR, Rodriguez PC, Gabrilovich DI, Conejo-Garcia JR. Science. 2020 Aug 21;369(6506):942-949. doi: 10.1126/science.aay2767. PMID: 32820120.
Exosomes Produced by Mesenchymal Stem Cells Drive Differentiation of Myeloid Cells into Immunosuppressive M2-Polarized Macrophages in Breast Cancer. Biswas S*, Mandal G*, Roy Chowdhury S, Purohit S, Payne KK, Anadon C, Gupta A, Swanson P, Yu X, Conejo-Garcia JR, Bhattacharyya A. Journal of Immunology. 2019 Dec 15;203(12):3447-3460. doi: 10.4049/jimmunol.1900692. Epub 2019 Nov 8. PMID: 31704881. (*co-first authors)
Heterodimer formation by Oct4 and Smad3 differentially regulates epithelial-to-mesenchymal transition-associated factors in breast cancer progression. Mandal G, Biswas S, Roy Chowdhury S, Chatterjee A, Purohit S, Khamaru P, Chakraborty S, Mandal PK, Gupta A, de la Mare JA, Edkins AL, Bhattacharyya A. Biochimica et Biophysica Acta Molecular Basis of Disease. 2018 Jun;1864(6 Pt A):2053-2066. doi: 10.1016/j.bbadis.2018.03.010. Epub 2018 Mar 8. PMID: 29526821.

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gunjan@ils.res.inInstitute of Life Sciences, Nalco Square, Chandrasekharpur, Bhubaneswar-751023, Odisha, India