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Dr. Sanjeeb Kumar Sahoo

Academics

Degree University/Institution
M.Sc.: ChemistryUniversity of Delhi, India
Ph.D in ScienceUniversity of Delhi, India

Work Experience

Position University/Organisation Period
Scientist GBRIC - Institute of Life Sciences, Bhubaneswar2025 – Cont.
Scientist FInstitute of Life Sciences, Bhubaneswar2021 – 2024
Scientist EInstitute of Life Sciences, Bhubaneswar2016 – 2020
Scientist DInstitute of Life Sciences, Bhubaneswar2010 – 2015
Scientist CInstitute of Life Sciences, Bhubaneswar2007- 2010
Scientist BInstitute of Life Sciences, Bhubaneswar2005 – 2007
Research AssociateUniversity of Nebraska Medical Center, Omaha, NE, USAJuly 2004 to June 2005
Postdoctoral Research AssociateUniversity of Nebraska Medical Center. Omaha, NE, USASeptember 2001 to June 2004
Postdoctoral Research FellowJSPS Postdoctoral fellow, Kumamoto University School of Medicine, Kumamoto, JapanAugust 1999 to August 2001
ScientistDabur Research Foundation. Dabur India Ltd., IndiaMarch 1999 to August 1999
Research FellowUniversity of Nottingham, Nottingham, U. KJanuary 1998 to March 1998

Awards & Recognition

Details

• Among Top 2% Scientists in world ranking brought out by Stanford University, 2020, 2021, 2022, 2023, 2024, and 2025.
• Listed amongst World’s top 2% highly cited Scientists by Stanford University in 2020.
• Highly Cited Researcher in 2018 in the field of pharmacology and toxicology from Clarivate Analytics, USA.(Recognised as one of the top 10 Scientists from India in the list of top 4000 Scientists across the globe.
• Awarded Samanta Chandrasekhar Award from Odisha Bigyan Academy Govt. of Odisha in 2011.
• Awarded International Fellowship for Young Biomedical Scientists in 2008 from ICMR to work at Creighton University, Omaha, Nebraska, USA.
• Awarded Postdoctoral fellowship from the American Heart Association (AHA), United States of America (2002-2004).
• Awarded Japanese Society for Promotion of Science (JSPS) postdoctoral fellowship from the Government of Japan (1999-2001).
• Awarded Senior Research Fellowship (SRF, 1998-1999), University Grant Commission, Government of India.
• Awarded travel grants from University of London to attend the 3rd International symposium on Polymer Therapeutics from Laboratory to Clinical Practice, School of Pharmacy, University of London, UK, 1998.
• Awarded Junior Research Fellowship (JRF, 1996-98) University Grant Commission, Government of India.
• Secured (84.07 percentile) All India Graduate Aptitude Test in Engineering (GATE) in 1996.

Membership of Professional Associations / Societies:
• Section Editor (Cancer), Current Pharmaceutical Biotechnology
• Member, Editorial Board, Current Nanomedicine
• Member, Editorial Board, Clinical & Experimental Pharmacology
• Member, Editorial Board, Future Nanomedicine

Reviewer of Scientific Journals:
Journal of Colloid and Interface Science, Biomacromolecules, Journal of Biomedical Nanotechnology, Drug Discovery Today, Export Opinion in Drug Delivery, Asain Journal of Pharmaceutics, Biomedical Materials, Future Nanomedicine, International Journal of Nanomedicine, Journal of Physics Condensed Matter, Nanotechnology, Expert Review of Molecular Diagnostics, Biomaterials, Nanomedicine: Nanotechnology, Biology and Medicine, Current Nanosciences, Pharmaceutical Research, Journal of Controlled Release, Biomacromolecules, Journal of Ameican Chemical Scociety, Small, Europian Journal of Pharmaceutics and Biopharmaceutics, Therapeutic Delivery, Tumor Biology, Chinise Medicine, future Oncology, Nanotechnology, Journal of Biomaterials Application, Cancer research, Macromolecular Biosciences, ACS Nano, Advanced Healthcare Biomaterials, Oncotarget.

Research

Details
Nanomedicine mediated targeting of Cancer Stem-Like Cells

Chemoresistance and cancer relapse marks the significant challenges in cancer management and are attributable in part to the presence of cancer cells subpopulations termed as cancer stem cells or tumor initiating cells. Although their mode of generation and biological properties has been explored in diverse array of cancer types, our understanding of the biology of the CSCs remains superficial. Due to their extraordinary characteristics, CSCs are thought to be the basis for tumor initiation, development, metastasis and recurrence. Researchers have identified multiple potential therapeutic targets to CSCs, including the ABC superfamily, anti-apoptotic factors, detoxifying enzymes, DNA repair enzymes and distinct oncogenic cascades (such as the Wnt/β-catenin, hedgehog, EGFR and Notch pathways) which are used preferentially or uniquely by these cells. Evidences exists indicating that non-CSCs in the tumor can spontaneously and stochastically turn into CSCs de novo, undermining the efficacy of therapeutic strategy that only targets CSCs. Hence, it becomes crucial to eliminate both CSCs and non-CSCs simultaneously for effective cancer therapy. Our group is thus working on combinational approach for effective cancer treatment. We have focused our studies based on dual drug delivery systems targeting CSCs specific signaling pathway and simultaneously targeting non-CSCs to get rid of cancer relapse and metastasis in both in-vitro and in-vivo models.

Magnetic nanoparticles as a theranostic tool in cancer therapy

Development of magnetic nanoparticles (MNPs) as a theranostic agent in cancer therapy has growing importance due to their application both as a drug delivery agent for therapeutic purpose and imaging agent for diagnostic purpose. The role of MNPs as a contrast agent for the magnetic resonance imaging (MRI) has gained significant attention in cancer therapy as early diagnosis of cancer has always remained a challenge. Further, the therapeutic applications of magnetic nanoparticles account for targeted delivery of therapeutic agents and also another upcoming therapeutic mode of treatment for cancer i.e, hyperthermia. MNPs in presence of alternating magnetic field can induce heat that can kill the cancer cells and may enhance the therapeutic index of the chemotherapeutic drugs and also may help in eliminating the cancer stem cells that are the major cause of relapse of cancer. However, the majority of research in this area is still at the bench side and clinical translation is restricted by instability of the MNPs. Thus, development of aqueous dispersible magnetic nanoparticles having sufficient magnetization is necessary that can be used for different biomedical applications like drug delivery, contrast agent for MRI, hyperthermia, cell separation etc. In this regard, we have synthesized an aqueous dispersible highly stable polymer coated magnetic nanoparticle formulation (Indian Patent Application No 779/KOL/2009 of 21/5/2009 and International PCT Application No.PCT/IN09/000639 of 12/11/2009). Our lab is extensively using the above MNPs formulation for different biomedical applications for cancer management.

Publications

Details

Research Papers Published (Peer-reviewed Journals)

  1. Vishwakarma A, Sahu TK, Patra SG, Paul C, Behera S, Sahoo S K, Khan T. Sulfonylative-arylation of acrylamides via strain-release-/aromaticity-driven radical generation and SO2-capture under photoredox catalysis to access S(VI)-oxindoles. Eur J Org Chem. 2025;28:e202500726.
  2. Jana P, Sa P, Sakai K, Sahoo S K, Madhyastha H, Dev A. Enhancement of the antitumor efficacy of docetaxel using αvβ3 integrin and CD44 dual receptor-targeted carbon dot-based nanodelivery in breast cancer. Mol Pharm. 2025;22:6120–6140.
  3. Biswal S, Sahoo S K, Biswal BK. Shikonin, a potent phytotherapeutic: A comprehensive review on metabolic reprogramming to overcome drug resistance in cancer. Mol Biol Rep. 2025;52:347.
  4. Dash S, Swain SS, Khuntia A, Dutta S, Sahoo S K. Nanotheranostics: A cutting-edge technology for cancer management. Curr Pharm Biotechnol. 2025;26(8):1099–1119.
  5. Sahoo S, Sahoo S K. Phytonanomedicine as a therapeutic regulator of the tumor microenvironment for inhibiting cancer metastasis. Nanomedicine (Lond). 2024;19(14):1227–1229.
  6. Swain SS, Sahoo S K. Piperlongumine and its derivatives against cancer: A recent update and future perspective. Arch Pharm (Weinheim). 2024;357(7):e2300768.
  7. Sa P, Singh P, Panda S, Swain RK, Dash R, Sahoo S K. Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine-loaded smart nanoparticles through inhibition of Hippo–YAP signalling pathway. Transl Res. 2024;268:63–78.
  8. Singh P, Sen K, Sa P, Khuntia A, Raghav SK, Swain RK, Sahoo S K. Piperlongumine-based nanomedicine impairs glycolytic metabolism in triple-negative breast cancer stem cells through modulation of GAPDH and FBP1. Phytomedicine. 2024;123:155181.
  9. Mohapatra P, Madhulika S, Behera S, Singh P, Sa P, Prasad P, Swain SK, Sahoo S K. Nimbolide-based nanomedicine inhibits breast cancer stem-like cells by epigenetic reprogramming of DNMTs–SFRP1–Wnt/β-catenin signalling axis. Mol Ther Nucleic Acids. 2023;34:102031.
  10. Thalappil MA, Singh P, de Prati AC, Sahoo S K, Moriotto S, Butturini E. Essential oils and their nanoformulations for breast cancer therapy. Phytother Res. 2023;1–36.
  11. Sa P, Mohapatra P, Swain SS, Khuntia A, Sahoo S K. Phytochemical-based nanomedicine for targeting tumor microenvironment and inhibiting cancer chemoresistance: Recent advances and pharmacological insights. Mol Pharm. 2023;20(11):5254–5277.
  12. Sa P, Sahoo S K, Dilnawaz F. Responsive role of nanomedicine in the tumor microenvironment and cancer drug resistance. Curr Med Chem. 2023;30:3335–3355.
  13. Mahapatra M, Mohapatra P, Pakeeraiah K, Bandaru RK, Ahmad I, Mal S, Dandela R, Sahoo S K, Patel H, Paidesetty SK. In vitro anticancer evaluation of newly designed and characterized tri/tetra-substituted imidazole congeners—maternal embryonic leucine zipper kinase inhibitors: Molecular docking and MD simulation approaches. Int J Biol Macromol. 2023;249:126084.
  14. Pattnaik S, Mohanty S, Sahoo S K, Mohanty C. A mechanistic perspective on the role of phytoconstituent-based pharmacotherapeutics and their topical formulations in chronic wound management. J Drug Deliv Sci Technol. 2023;84:104546.
  15. Mahapatra M, Mohapatra P, Sahoo S K, Bishoyi AK, Padhy RN, Paidesetty SK. Design, synthesis, and in silico study of chromen–sulfonamide congeners as potent anticancer and antimicrobial agents. J Mol Struct. 2023;1283:135190.
  16. Mohanty S, Mohanty M, Sarma K, Kumar K, Dey A, Das P, Sahoo S K. Classical morphology and DNA barcoding-based identification of freshwater ectoparasite Argulus foliaceus in rohu Labeo rohita. Indian J Fish. 2023;70(1):111–118.
  17. Mohapatra M, Mekap SK, Mal S, Sahoo J, Sahoo S K, Paidesetty SK. Coumaryl–sulfonamide moiety: Unraveling their synthetic strategy and specificity towards hCA IX/XII, facilitating anticancer drug development. Arch Pharm. 2023;356(4):e2200508.
  18. Sahoo S, Mohapatra P, Sahoo S K. Flavonoids for the treatment of breast cancer: Present status and future perspective. Anticancer Agents Med Chem. 2022;23:658–675.
  19. Sharma T, Singh D, Mahapatra A, Mohapatra P, Sahoo S, Sahoo S K. Advancements in clinical translation of flavonoid nanoparticles for cancer treatment. OpenNano. 2022;8:100074.
  20. Mohapatra P, Singh P, Singh D, Sahoo S, Sahoo S K. Phytochemical-based nanomedicine: A panacea for cancer treatment, present status and future perspective. OpenNano. 2022;7:100055.
  21. Sa P, Singh P, Dilnawaz F, Sahoo S K. Application of therapeutic nanoplatforms as a potential candidate for the treatment of CNS disorders: Challenges and possibilities. Curr Pharm Des. 2022;28:2742–2757.
  22. Kerry RG, Mohapatra P, Jena AB, Panigrahi B, Pradhan KC, Khatua BR, Mahari S, Pal S, Perikala V, Kisan B, Lugos MD, Mondru AK, Sahoo S K, Mandal D, Majhi S, Patra JK. Biosynthesis of rutin trihydrate-loaded silica nanoparticles and investigation of its antioxidant, antidiabetic and cytotoxic potentials. Inorg Organomet Polym Mater. 2022;32(6):2065–2081.
  23. Alam J, Dilnawaz F, Sahoo S K, Singh DV, Mukhopadhyay AK, Hussain T, Pati S. Curcumin encapsulated into biocompatible co-polymer PLGA nanoparticle enhanced anti-gastric cancer and anti-Helicobacter pylori effect. Asian Pac J Cancer Prev. 2022;23(1):61–70.
  24. Singh P, Sahoo S K. Piperlongumine-loaded PLGA nanoparticles inhibit cancer stem-like cells through modulation of STAT3 in mammosphere model of triple-negative breast cancer. Int J Pharm. 2022;616:121526.
  25. Singh D, Mohapatra P, Kumar S, Behera S, Dixit A, Sahoo S K. Nimbolide-encapsulated PLGA nanoparticles induce mesenchymal-to-epithelial transition by dual inhibition of AKT and mTOR in pancreatic cancer stem cells. Toxicol In Vitro. 2022;79:105293.
  26. Singh P, Singh D, Sa P, Mohapatra P, Khuntia A, Sahoo S K. Insights from nanotechnology in COVID-19: Prevention, detection, therapy and immunomodulation. Nanomedicine (Lond). 2021;16(14):1219–1235.
  27. Singh D, Singh P, Pradhan A, Srivastava A, Sahoo S K. Reprogramming cancer stem-like cells with nanoforskolin enhances the efficacy of paclitaxel in targeting breast cancer. ACS Appl Bio Mater. 2021;4:3670–3685.
  28. Mandal M, Sahoo S K, Patra P, Mallik S, Zhao Z. In silico ranking of phenolics for therapeutic effectiveness on cancer stem cells. BMC Bioinformatics. 2020;21(Suppl 21):499.
  29. Mohapatra P, Singh P, Sahoo S K. Phytonanomedicine: A novel avenue to treat recurrent cancer by targeting cancer stem cells. Drug Discov Today. 2020;25(8):1307–1321.
  30. Kundu P, Singh D, Singh A, Sahoo S K. Cancer nanotheranostics: A nanomedicinal approach for cancer therapy and diagnosis. Anticancer Agents Med Chem. 2020;20(11):1288–1299.
  31. Singh A, Jain S, Sahoo S K. Magnetic nanoparticles for amalgamation of magnetic hyperthermia and chemotherapy: An approach towards enhanced attenuation of tumor. Mater Sci Eng C. 2020;110:110695.
  32. Singh D, Dilnawaz F, Sahoo S K. Challenges of moving theranostic nanomedicine into the clinic. Nanomedicine (Lond). 2020;15(2):111–114.
  33. Pradhan J, Mohanty C, Sahoo S K. Protective efficacy of crocetin and its nanoformulation against cyclosporine A-mediated toxicity in human embryonic kidney cells. Life Sci. 2019;216:39–48.
  34. Chintala R, Dilnawaz F, Panigrahi M, Sahoo S K, Babu PP. Paclitaxel-loaded magnetic nanoparticles induce in vivo tumor growth inhibition in a rat glioblastoma model. Int J Pharm Clin Res. 2018;10(7):176–182.
  35. Arya G, Das M, Sahoo S K. Evaluation of curcumin-loaded chitosan/PEG-blended PLGA nanoparticles for effective treatment of pancreatic cancer. Biomed Pharmacother. 2018;102:555–566.
  36. Dilnawaz F, Acharya S, Sahoo S K. Recent trends of nanomedicinal approaches in clinics. Int J Pharm. 2018;538:263–278.
  37. Dilnawaz F, Sahoo S K. Augmented anticancer efficacy by siRNA-complexed drug-loaded mesoporous silica nanoparticles in lung cancer therapy. ACS Appl Nano Mater. 2018;1(2):730–740.
  38. Parhi P, Suklabaidya S, Sahoo S K. Enhanced anti-metastatic and anti-tumorigenic efficacy of berbamine-loaded lipid nanoparticles in vivo. Sci Rep. 2017;7:5296.
  39. Mohanty C, Sahoo S K. Curcumin and its topical formulations for wound healing applications. Drug Discov Today. 2017;22(10):1582–1592.
  40. Singh D, Minz AP, Sahoo S K. Nanomedicine-mediated drug targeting of cancer stem cells. Drug Discov Today. 2017;22(6):952–959.
  41. Kundu P, Das M, Tripathy K, Sahoo S K. Delivery of dual drug-loaded lipid-based nanoparticles across the blood–brain barrier imparts enhanced neuroprotection in a rotenone-induced mouse model of Parkinson’s disease. ACS Chem Neurosci. 2016;7(12):1658–1670.
  42. Acharya S, Sahoo S K. Exploitation of redox discrepancy in leukemia cells by a reactive oxygen species nanoscavenger for inducing cytotoxicity in imatinib-resistant cells. J Colloid Interface Sci. 2016;467:180–191.
  43. Vidyasekar P, Shyamsunder P, Sahoo S K, Verma RS. Scaffold-free and scaffold-assisted 3D culture enhances differentiation of bone marrow stromal cells. In Vitro Cell Dev Biol. 2015;51:971–982.
  44. Mohanty C, Kundu P, Sahoo S K. Brain targeting of siRNA via intranasal pathway. Curr Pharm Des. 2015;21(31):4606–4613.
  45. Singh A, Jain S, Senapati S, Verma RS, Sahoo S K. Magnetic nanoparticles labeled mesenchymal stem cells: A pragmatic solution towards targeted cancer theranostics. Adv Healthc Mater. 2015;4:1–10.
  46. Dilnawaz F, Sahoo S K. Therapeutic approaches of magnetic nanoparticles for the central nervous system. Drug Discov Today. 2015;20(10):1256–1264.
  47. Vandana M, Sahoo S K. Synergistic activity of combination therapy with PEGylated pemetrexed and gemcitabine for effective cancer treatment. Eur J Pharm Biopharm. 2015;94:83–93.
  48. Parhi P, Sahoo S K. Trastuzumab-guided nanotheranostics: A lipid-based multifunctional nanoformulation for targeted drug delivery and imaging in breast cancer therapy. J Colloid Interface Sci. 2015;451:198–211.
  49. Das M, Duan W, Sahoo S K. Multifunctional nanoparticle–EpCAM aptamer bioconjugates: A paradigm for targeted drug delivery and imaging in cancer therapy. Nanomedicine. 2015;11(2):379–389.
  50. Misra R, Das M, Sahoo BS, Sahoo S K. Reversal of multidrug resistance in vitro by co-delivery of MDR1-targeting siRNA and doxorubicin using a novel cationic poly(lactide-co-glycolide) nanoformulation. Int J Pharm. 2014;475(1–2):372–384.
  51. Singh A, Sahoo S K. Magnetic nanoparticles: A novel platform for cancer theranostics. Drug Discov Today. 2014;19(4):474–481.
  52. Dilnawaz F, Singh A, Mewar S, Sharma U, Jagannathan NR, Sahoo S K. The transport of non-surfactant-based paclitaxel-loaded magnetic nanoparticles across the blood–brain barrier in a rat model. Biomaterials. 2012;33(10):2936–2951.
  53. Hermann PC, Trabulo SM, Sainz B Jr, Balic A, Garcia E, Hahn SA, Vandana M, Sahoo S K, Tunici P, Bakker A, Hidalgo M, Heeschen C. Multimodal treatment eliminates cancer stem cells and leads to long-term survival in primary human pancreatic cancer tissue xenografts. PLoS One. 2013;8(6):e66371.
  54. Mohanty C, Das M, Sahoo S K. Emerging role of nanocarriers to increase the solubility and bioavailability of curcumin. Expert Opin Drug Deliv. 2012;9(11):1347–1364.
  55. Mohanty C, Das M, Sahoo S K. Sustained wound healing activity of curcumin-loaded oleic acid-based polymeric bandage in a rat model. Mol Pharm. 2012;9(10):2801–2811.
  56. Vandana M, Sahoo S K. Reduced folate carrier–independent internalization of PEGylated pemetrexed: A potential nanomedicinal approach for breast cancer therapy. Mol Pharm. 2012;9(10):2828–2843.
  57. Mitra M, Mohanty C, Harilal A, Maheswari UK, Sahoo S K, Krishnakumar S. A novel in vitro 3D retinoblastoma model for evaluating chemotherapeutic drugs. Mol Vis. 2012;18:1361–1378.
  58. Akhtar J, Mallaredy V, Dandapat J, Maiti P, Sahoo S K, Singh S. PEGylation of an osteoclast inhibitory peptide: Suitable candidate for the treatment of osteoporosis. Int J Pharm. 2012;434(1–2):429–436.
  59. Parhi P, Mohanty C, Sahoo S K. Nanotechnology-based combinational drug delivery: An emerging approach for cancer therapy. Drug Discov Today. 2012;17(17–18):1044–1052.
  60. Das M, Sahoo S K. Folate-decorated curcumin-loaded nanoparticles reverse multidrug resistance and enhance therapeutic potential of nutlin-3a in retinoblastoma. PLoS One. 2012;7(3):e32920.
  61. Misra R, Sahoo S K. Antibacterial activity of doxycycline-loaded nanoparticles. Methods Enzymol. 2012;509:61–85.
  62. Dilnawaz F, Singh A, Mewar S, Sharma U, Jagannathan NR, Sahoo S K. The transport of non-surfactant-based paclitaxel-loaded magnetic nanoparticles across the blood–brain barrier in a rat model. Biomaterials. 2012;33(10):2936–2951.
  63. Parveen S, Misra R, Sahoo S K. Nanoparticles: A boon to drug delivery, therapeutics, diagnostics and imaging. Nanomedicine. 2012;8(2):147–166.
  64. Singh A, Dilnawaz F, Sahoo S K. Long-circulating lectin-conjugated paclitaxel-loaded magnetic nanoparticles: A new theranostic avenue for leukemia therapy. PLoS One. 2011;6(11):e26803.
  65. Parveen S, Sahoo S K. Long-circulating chitosan/PEG-blended PLGA nanoparticles for tumor drug delivery. Eur J Pharmacol. 2011;670:372–383.
  66. Devilakshmi S, Palanivelu S, Krishnakumar S, Sahoo S K, Verma RS. Monoclonal antibody for specific targeting of Ep-CAM in various carcinomas. Hybridoma. 2011;30(6):511–518.
  67. Behera T, Swain P, Sahoo S K, Mohapatra D, Das BK. Immunostimulatory effect of curcumin in fish Labeo rohita. Indian J Nat Prod Resour. 2011;2(2):184–188.
  68. Acharya S, Sahoo S K. Sustained targeting of BCR-ABL+ leukemia cells by synergistic action of dual drug-loaded nanoparticles: An implication for leukemia therapy. Biomaterials. 2011;32(24):5643–5662.
  69. Misra R, Sahoo S K. Co-formulation of doxorubicin and curcumin in poly(D,L-lactide-co-glycolide) nanoparticles suppresses the development of multidrug resistance in K562 cells. Mol Pharm. 2011;8(3):852–866.
  70. Arya G, Vandana M, Acharya S, Sahoo S K. Enhanced antiproliferative activity of Herceptin (HER2)-conjugated gemcitabine-loaded chitosan nanoparticles in pancreatic cancer therapy. Nanomedicine. 2011;7(6):859–870.
  71. Behera T, Swain P, Sahoo S K. Antigen in chitosan-coated liposomes enhances immune responses through parenteral immunization. Int Immunopharmacol. 2011;11(8):907–914.
  72. Mitra M, Dilnawaz F, Misra R, Sarkar S, Krishnakumar S, Sahoo S K. Toxicogenomics of nanoparticulate delivery of etoposide: Potential impact on nanotechnology in retinoblastoma therapy. Cancer Nano. 2011;2(1–6):21–36.
  73. Acharya S, Sahoo S K. PLGA nanoparticles containing various anticancer agents and tumor delivery by EPR effect. Adv Drug Deliv Rev. 2011;63:170–183.
  74. Das M, Dilnawaz F, Sahoo S K. Targeted nutlin-3a–loaded nanoparticles inhibiting p53–MDM2 interaction: Novel strategy for breast cancer therapy. Nanomedicine (Lond). 2011;6(3):489–507.
  75. Mohanty C, Das M, Kanwar JR, Sahoo S K. Receptor-mediated tumor targeting: An emerging approach for cancer therapy. Curr Drug Deliv. 2011;8(1):45–58.
  76. Parveen S, Sahoo S K. Evaluation of cytotoxicity and mechanism of apoptosis of doxorubicin using folate-decorated chitosan nanoparticles for targeted delivery to retinoblastoma. Cancer Nano. 2010;1:47–62.
  77. Behera AL, Patil SV, Sahoo S K. Nanosizing of drugs: A promising approach for drug delivery. Int J Pharm Technol. 2010;2(1):45–56.
  78. Vandana M, Sahoo S K. Long circulation and cytotoxicity of PEGylated gemcitabine and its potential for the treatment of pancreatic cancer. Biomaterials. 2010;31:9340–9356.
  79. Misra R, Acharya S, Sahoo S K. Cancer nanotechnology: Application of nanotechnology in cancer therapy, diagnosis and imaging. Drug Discov Today. 2010;15(19–20):842–850.
  80. Mohanty C, Sahoo S K. The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation. Biomaterials. 2010;31(25):6597–6611.
  81. Singh A, Misra R, Mohanty C, Sahoo S K. Applications of nanotechnology in vaccine delivery. Int J Green Nanotechnol Biomed. 2010;2:B25–B45.
  82. Mohanty AK, Dilnawaz F, Sahoo S K. Etoposide-loaded biodegradable amphiphilic methoxy(polyethylene glycol)–poly(ε-caprolactone) copolymeric micelles as drug delivery vehicle for cancer therapy. Drug Deliv. 2010;17(5):1–13.
  83. Dilnawaz F, Singh A, Mohanty C, Sahoo S K. Targeted dual drug-loaded superparamagnetic iron oxide nanoparticles for cancer therapy. Biomaterials. 2010;31:3694–3706.
  84. Mohanty C, Acharya S, Mohanty AK, Dilnawaz F, Sahoo S K. Curcumin-encapsulated MePEG/PCL block copolymeric micelles: A novel controlled delivery vehicle for cancer therapy. Nanomedicine. 2010;5(3):433–449.
  85. Misra R, Sahoo S K. Intracellular trafficking of nuclear localization signal–conjugated nanoparticles for cancer therapy. Eur J Pharm Sci. 2010;39:152–163.
  86. Behera T, Nanda PK, Mohanty C, Mohapatra D, Swain P, Das BK, Routray P, Mishra BK, Sahoo S K. Parenteral immunization of fish Labeo rohita with PLGA-encapsulated antigen microparticles promotes innate and adaptive immune responses. Fish Shellfish Immunol. 2010;28:320–325.
  87. Vandana M, Sahoo S K. Optimization of physicochemical parameters influencing the fabrication of protein-loaded chitosan nanoparticles. Nanomedicine. 2009;4(7):373–385.
  88. Mohanty C, Arya G, Verma RS, Sahoo S K. Nanobiotechnology: Application of nanotechnology in therapeutics and diagnosis. Int J Green Nanotechnol Biomed. 2009;1:B24–B38.
  89. Acharya S, Dilnawaz F, Sahoo S K. Targeted EGFR–nanoparticle bioconjugates for breast cancer therapy. Biomaterials. 2009;30:5737–5750.
  90. Misra R, Acharya S, Dilnawaz F, Sahoo S K. Sustained antibacterial activity of doxycycline-loaded PLGA and poly(ε-caprolactone) nanoparticles. Nanomedicine. 2009;4(5):519–530.
  91. Das M, Mohanty C, Sahoo S K. Ligand-based targeted therapy for cancer tissue. Expert Opin Drug Deliv. 2009;6:285–304.
  92. Baratchi S, Kaur RK, Khoshmanesh V, Vasu P, Ashok C, Hittu M, Parratt A, Krishnakumar S, Sun X, Sahoo S K, Kanwar JR. Promises of nanotechnology for drug delivery to brain in neurodegenerative diseases. Curr Nanosci. 2009;5:15–25.
  93. Reddy MK, Vasir JK, Sahoo S K, Jain TK, Yallapu MM, Labhasetwar V. Inhibition of apoptosis through localized delivery of rapamycin-loaded nanoparticles prevents neointimal hyperplasia and re-endothelializes injured artery. Circ Cardiovasc Interv. 2008;1:209–216.
  94. Horning JL, Sahoo S K, Vijayaraghavalu S, Dimitrijevic S, Vasir JK, Jain TK, Panda AK, Labhasetwar V. Three-dimensional tumor model for in vitro evaluation of anticancer drugs. Mol Pharm. 2008;5(5):849–862.
  95. Potala S, Sahoo S K, Verma R. Targeted therapy of cancer using diphtheria toxin–derived immunotoxins. Drug Discov Today. 2008;13(17–18):807–815.
  96. Parveen S, Sahoo S K. Polymeric nanoparticles for cancer therapy. J Drug Target. 2008;16(2):108–123.
  97. Sahoo S K, Dilnawaz F, Krishnakumar K. Nanotechnology in ocular drug delivery. Drug Discov Today. 2008;13(3–4):144–151.
  98. Sahoo S K, Parveen S, Panda JJ. The present and future of nanotechnology in human health care. Nanomedicine. 2007;3(1):20–31.
  99. Parveen S, Krishnakumar K, Sahoo S K. New era in health care: Tissue engineering. J Stem Cells Regen Med. 2006;1(1):1–10.
  100. Parveen S, Sahoo S K. Nanomedicine: Clinical applications of polyethylene glycol–conjugated proteins and drugs. Clin Pharmacokinet. 2006;45(10):965–988.
  101. Sahoo S K. Applications of nanomedicine. Asia Pac Biotech News. 2005;9(20):48–50.
  102. Sahoo S K, Labhasetwar V. Enhanced antiproliferative activity of transferrin-conjugated paclitaxel nanoparticles is mediated via sustained intracellular drug retention. Mol Pharm. 2005;2(5):373–383.
  103. Jain TK, Morales MA, Sahoo S K, Leslie-Pelecky DL, Labhasetwar V. Novel formulation of iron-oxide nanoparticles for drug delivery. Mol Pharm. 2005;2(3):194–205.
  104. Sahoo S K, Panda AK, Labhasetwar V. Characterization of porous PLGA/PLA microparticles as a scaffold for three-dimensional growth of breast cancer cells. Biomacromolecules. 2005;6(2):1132–1139.
  105. Sahoo S K, Ma W, Labhasetwar V. Efficacy of transferrin-conjugated paclitaxel-loaded nanoparticles in a murine model of prostate cancer. Int J Cancer. 2004;112:335–340.
  106. Sahoo S K, Labhasetwar V. Nanotech approaches in drug delivery and imaging. Drug Discov Today. 2003;8(24):1112–1120.
  107. Panayam J, Dhali MP, Sahoo S K, Ma W, Chakravarthi S, Amidon AG, Levy RJ, Labhasetwar V. Polymer degradation and in vitro release of a model protein from poly(D,L-lactide-co-glycolide) nano- and microparticles. J Control Release. 2003;92:173–187.
  108. Panyam J, Sahoo S K, Prabha S, Labhasetwar V. Fluorescence and electron microscopy probes for poly(D,L-lactide-co-glycolide) nanoparticles. Int J Pharm. 2003;262(1–2):1–11.
  109. Fang J, Sawa T, Akaike T, Akuta T, Sahoo S K, Khaled G, Hamada A, Maeda H. In vivo antitumor activity of pegylated zinc protoporphyrin: Targeted inhibition of heme oxygenase in solid tumor. Cancer Res. 2003;63(13):3567–3574.
  110. Bharali DJ, Sahoo S K, Majumdar S, Maitra AN. Nanometer-size polyvinylpyrrolidone nanoparticles as drug delivery carriers. J Colloid Interface Sci. 2003;258(2):415–423.
  111. Sahoo S K, Panyam J, Prabha S, Labhasetwar V. Residual polyvinyl alcohol associated with poly(D,L-lactide-co-glycolide) nanoparticles affects their physical and cellular uptake properties. J Control Release. 2002;82:105–114.
  112. Sahoo S K, Sawa T, Fang J, Tanaka S, Akaike T, Maeda H. PEGylated zinc protoporphyrin: A water-soluble heme oxygenase inhibitor with tumor-targeting capacity. Bioconjug Chem. 2002;13(5):1031–1038.
  113. Panyam J, Zhou WZ, Prabha S, Sahoo S K, Labhasetwar V. Rapid endo-lysosomal escape of poly(D,L-lactide-co-glycolide) nanoparticles: Implication for drug and gene delivery. FASEB J. 2002;16:1217–1226.
  114. Gaur U, Sahoo S K, De TK, Ghosh PC, Maitra AN, Ghosh PK. Biodistribution of fluoresceinated dextran using novel nanoparticles evading the reticuloendothelial system. Int J Pharm. 2000;202:1–10.
  115. Sahoo S K, De TK, Ghosh PK, Maitra AN. pH- and thermo-sensitive hydrogel nanoparticles. J Colloid Interface Sci. 1998;206:361–368.

Book Chapters

  1. Sawa T, Sahoo S K, Maeda H. Water-soluble polymer therapeutics with a special emphasis on cancer chemotherapy. In: Arshady R, editor. Polymeric Biomaterials, The PBM Series, Vol 1: Introduction to Polymeric Biomaterials. London: Citus Books; 2003. p. 233–261.
  2. Sahoo S K, Labhasetwar V. Nanoparticle interface: An important determinant in nanoparticle-mediated drug/gene delivery. In: Gupta RB, Kompella UB, editors. Nanoparticle Technology for Drug Delivery. New York: Taylor & Francis; 2005. p. 139–160.
  3. Sahoo S K, Labhasetwar V. Biodegradable PLGA nanoparticles for anticancer therapy. In: Amiji M, editor. Nanotechnology for Cancer Therapeutics. Boca Raton: CRC Press; 2007. p. 243–250.
  4. Sahoo S K, Jain T, Reddy MK, Labhasetwar V. Nano-sized carriers for drug delivery. In: Shoseyov O, Levy I, editors. Nanobiotechnology. Totowa, NJ: Humana Press; 2007. p. 329–348.
  5. Dilnawaz F, Sahoo S K. Nanotechnology and its impact on aquaculture. In: Roy AK, Sarangi N, editors. Applied Bioinformatics, Statistics and Economics in Fisheries Research. New Delhi: New India Publishing Agency; 2008. p. 247–259.
  6. Mohanty C, Acharya S, Sahoo S K. Micelle: The multifunctional nanocarrier for colloidal drug delivery. In: Fanun M, editor. Colloids in Drug Delivery. Boca Raton: Taylor & Francis/CRC Press; 2010. p. 157–176.
  7. Dilnawaz F, Acharya S, Misra R, Singh A, Sahoo S K. Nanotechnology and drug delivery. In: Sattler KD, editor. Bionanoscience, Nanorobotics, and Nanomedicine. Boca Raton: Taylor & Francis; 2010. p. 27–49.
  8. Mohanty C, Vandana M, Singh A, Sahoo S K. Nanomedicine: Emerging field of nanotechnology to human health. In: Sahoo S K, editor. Nanotechnology in Human Health Care. Singapore: Pan Stanford Publishing; 2012. p. 1–41.
  9. Das M, Mohanty C, Sahoo S K. Nanotechnology for regenerative medicine. In: Sahoo S K, editor. Nanotechnology in Human Health Care. Singapore: Pan Stanford Publishing; 2012. p. 297–319.
  10. Dilnawaz F, Singh A, Sahoo S K. Magnetic nanoparticles versatility in therapeutics and imaging. In: Sahoo S K, editor. Nanotechnology in Human Health Care. Singapore: Pan Stanford Publishing; 2012. p. 215–236.
  11. Dilnawaz F, Sahoo S K. Iron oxide in drug delivery. In: Arias JL, editor. Nanotechnology in Drug Delivery. Boca Raton: CRC Press; 2014. p. 328–343.
  12. Dilnawaz F, Sahoo S K. Nanotechnology-based ophthalmic drug delivery system. In: Domb AJ, editor. Focal Controlled Drug Delivery. Cham: Springer; 2014. p. 225–243.
  13. Mohanty AK, Dilnawaz F, Mohanta GP, Sahoo S K. Polymer–drug conjugates for drug delivery. In: Devarajan PV, Jain S, editors. Targeted Drug Delivery: Concepts and Design. Cham: Springer; 2015. p. 389–407.
  14. Singh A, Sahoo S K. Stem-cell nanoengineering: Exploration in a rapidly moving field. In: Baharvand H, Aghdami N, editors. Stem-Cell Nanoengineering. Chichester: Wiley-Blackwell; 2015. p. 87–95.
  15. Dilnawaz F, Sahoo S K. Nanosystems in ocular bio-environment. In: Pathak Y, et al., editors. Nano Biomaterials for Ophthalmic Drug Delivery. Cham: Springer; 2016. p. 1–20.
  16. Singh D, Singh P, Minz AP, Sahoo S K. Advanced nanotherapeutic systems for drug delivery and imaging in cancer. In: Ahmad F, editor. Advanced Therapeutic Delivery for Cancer. Hershey, PA: IGI Global; 2018. p. 1–21.
  17. Singh P, Sahoo S K. Nano-oncology: Clinical application for cancer therapy and future perspectives. In: Saravanan M, Barabadi H, editors. Cancer Nano Theranostics. Cham: Springer Nature; 2021. p. 49–95.
  18. Mohapatra P, Singh D, Sahoo S K. PEGylated nanoparticles as a versatile drug delivery system. In: Jana S, Jana S, editors. Nanoengineering of Biomaterials. Weinheim: Wiley-VCH; 2022. p. 309–341.
  19. Dilnawaz F, Sahoo S K. Application of magnetic nanoparticles as drug delivery in cancer. In: Hussain CM, Patankar KK, editors. Fundamentals and Industrial Applications of Magnetic Nanoparticles. Amsterdam: Elsevier; 2022. p. 393–412.
  20. Sa P, Sahoo S K. Recent advances in aptamer-based nanomaterials in imaging and diagnostics of cancer. In: Kesharwani P, editor. Aptamers Engineered Nanocarriers for Cancer Therapy. Amsterdam: Elsevier; 2022. p. 347–366.
  21. Dutta S, Sahoo S K. Hypoxic tumor microenvironment: Driver for cancer progression. In: Mukherjee S, Kanwar JR, editors. Hypoxia in Cancer: Significance and Impact on Cancer Therapy. Cham: Springer Nature; 2023. p. 65–88.
  22. Dash S, Sahoo S, Sahoo S K. Potential application of nanotechnology in the treatment and overcoming of pancreatic cancer resistance. In: Kesharwani P, Gupta N, editors. Recent Advancements in Nanocarriers for Pancreatic Cancer Therapy. Cambridge, MA: Academic Press; 2024. p. 37–63.
  23. Swain SS, Sahoo S K. Injection-molded plastic array three-dimensional universal culture platform for various biological applications. In: Dilnawaz F, Sharma T, Sahoo S K, Senapati S, editors. 3D Bio-printing in Cancer Applications. Cambridge, MA: Academic Press; 2025. p. 139–160.
  24. Khuntia A, Dash S, Swain SS, Sahoo S K. Three-dimensional bioprinted models for drug screening, cancer metastasis and prognosis study. In: Dilnawaz F, Sharma T, Sahoo S K, Senapati S, editors. 3D Bio-printing in Cancer Applications. Cambridge, MA: Academic Press; 2025. p. 161–190.

National and International Patents

  1. Maitra AN, Ghosh PK, De TK, Sahoo S K. Process for the preparation of highly monodispersed polymeric hydrophilic nanoparticles. U.S. Patent US 5,874,111; Japan Patent 330406/98; European Patent 973031271; Indian Patent Application 2350/DEL/96; 20 Dec 1996.
  2. Maitra AN, Ghosh PK, Sahoo S K; Dabur Research Foundation, Sahibabad, Ghaziabad, India. Formulation of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles. U.S. Patent US 6,322,817 B1.
  3. Maitra AN, Ghosh PK, Sahoo S K; Dabur Research Foundation, Sahibabad, Ghaziabad, India. Process for the preparation of pharmaceutical formulation of paclitaxel entrapped into polymeric micelle nanoparticles for the treatment of cancer. Indian Patent Application 263/DEL/99; 17 Feb 1999.
  4. Labhasetwar V, Sahoo S K, Reddy MK. Sustained release nanoparticle composition and methods for using the same. University of Nebraska Medical Center, Omaha, NE, USA. U.S. Patent US 7,727,554 B2.
  5. Labhasetwar V, Sahoo S K. Transferrin-conjugated nanoparticles for increasing efficacy of a therapeutic agent. University of Nebraska Medical Center, Omaha, NE, USA. U.S. Patent Application 11/124,934; filed 9 May 2005.
  6. Sahoo S K, Dilnawaz F, Singh A. Water-dispersible magnetic nanoparticle formulation. Indian Patent Application 779/KOL/2009; 21 May 2009; U.S. Patent US 9,271,934 B2; European Patents EP2432460A1, EP2432460A4, EP2432460B1.
  7. Sahoo S K, Mohanty C. Process for preparing curcumin-encapsulated chitosan–alginate sponge useful for wound healing. Indian Patent Application 1189/KOL/2010; 27 Oct 2010; U.S. Patent US 2013/0171215 A1; European Patents EP2632447A1, EP2632447B1.
  8. Sahoo S K, Vandana M. Water-soluble PEGylated pemetrexed and process for the same. Indian Patent Application 1405/KOL/2010; 18 Dec 2010.
  9. Sahoo S K, Parhi P, Mohanty C. Drug-delivery formulation of rapamycin in the form of polymeric nanoparticles. Indian Patent Application 38/KOL/2011.
  10. Sahoo S K, Vandana M. Water-soluble polymeric drug formulation and process for the same. Indian Patent Application 77/KOL/2011; 20 Jan 2011.
  11. Sahoo S K, Mohanty C. Process of producing amphotericin B (AmB)-loaded GMO nanoparticles. Indian Patent Application 914/KOL/2011; 6 Jul 2011.
  12. Sahoo S K, Dilnawaz F, Singh A, Patro R. Improved magnetic nanoparticle separation device. Indian Patent 397177; Application 201631024913; 19 May 2016 (granted 2022).

Group

Details

Nanotechnology (Cancer drug delivery) Lab

Dr. Dyuti Purkait
Project Scientist
Dr. Debasna Panigrahi
NPDF
Auromira Khuntia
SRF
Research interest – Magnetic nanoparticle based cancer immunotherapy.
Sneha Dutta
SRF
Research interest – Role of Nanomedicine in Chemo-immunotherapy.
Sonali Sahoo
SRF
Research interest – Role of CAF in tumor microenvironment.
Ananya Kashyap
SRF
Research interest – Metabolic Reprogramming of CAF using phytonanomedicine.
Soumya S Panda
JRF
Research interest – Phytonanomedicine driven immune rewiring in TNBC.
Rashmi R. Behera
JRF
Research interest – Phytonanomedicine targeting Hepatocellular carcinoma.
Alpana Choudhury
JRF
Research interest – Phytonanomedicine targeting TME of TNBC.
Ayana Sarangi
JRF
Research interest – Transcriptomic Insights into the Anticancer Mechanism of Nimbolide.
Sudhakar Panda
Senior Project Assosciate
Somalisa Behera
Lab Technician
Bhanupriya Dehury
Lab Technician
Lab: LC-HRMS
Sunita Nayak
Lab Technician
Lab: SEM

Former doctoral students

  • Dr. Suphiya Parveen: Assistant Professor, Jain University, Bangalore
  • Dr. Ranjita Mishra: Assistant Professor SRM university, Chennai
  • Dr. Manasi Das: Project Scientist II, University of California San Diego, USA
  • Dr. Vandana Mallaredy: PDF, Temple University, USA
  • Dr. Abhalaxmi Singh: Research Assistant Professor, University of Illinois, Chicago, USA
  • Dr. Sarbari Acharya: Assistant Professor KIIT University
  • Dr. Priyambada Parhi: PDF, Frankfurt University, Germany
  • Dr. Paromita Kundu: PDF, University of Rochester, USA
  • Dr. Deepika Singh: PDF, University of Texas San Antonio, USA
  • Dr. Priyambada Parhi: PDF, Frankfurt University, Germany
  • Dr. Paromita Kundu: PDF, University of Rochester, USA
  • Dr. Deepika Singh: PDF, University of Texas San Antonio, USA
  • Dr. Priya Singh:PDF, University of Pittsburg, PA , USA
  • Dr. Priyanka Mohapatra: PDF, University of Illinois, Chicago, USA
  • Dr. Pratikhshya Sa: PDF, IISER Berhampur, Odisha

Former Post doctoral students

  • Dr. Fahima Dilnawaz: Assistant professor, CUTM, Bhubaneshwar
  • Dr. Chandana Mohanty: Assistant professor, KIIT university, Bhubaneshwar
  • Dr. Jyotsnarani Pradhan: Assistant professor, Utkal University, Bhubaneshwar
  • Dr. Sasmita Das Sutar
  • Dr. Sashank Sekhar Swain

Grants

Contacts

EmailAddressFaxOffice
sanjeeb@ils.res.inNalco Square, Bhubaneswar-751023, India0091 674 23007280091 674 2304341

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