Dr. Rajeeb K. Swain

Academics

Degree	University/Institution
MSc. in Biotechnology	Savitribai Phule Pune University, India
P.hD. Developmental Biology	University of Tübingen, Germany.

Work Experience

Position	University/Organisation	Period
Scientist-F	Institute of Life Sciences, Bhubaneswar	January 2024 – Present
Scientist-E	Institute of Life Sciences, Bhubaneswar	January 2019 – December 2023
Scientist-D	Institute of Life Sciences, Bhubaneswar	September 2015 – December 2018
Ramalingaswami Fellow	Institute of Life Sciences, Bhubaneswar	December 2011 – December 2016
Post-doctoral Scientist	Paterson Institute for Cancer Research, Manchester, UK	January 2011 – December 2011
Research Fellow	University of Birmingham, Birmingham, UK	June 2006 – December 2010

Awards & Recognition

Research

Details
The focus of our laboratory is to understand how organs develop during embryogenesis. The organogenesis requires precise coordination of multiple biological processes including cell division, differentiation and migration regulated by well-orchestrated processes at the molecular level such as transcription factor activity, cell-to-cell communication, biochemical process and changes in cell architecture, among others. By studying developmental processes in the embryo, we aim to gain insights into how normal physiological functions are coordinated in adult tissues. Ultimately, this knowledge will help us better understand disease biology, where these cellular and molecular processes become dysregulated. In particular, we are investigating the molecular mechanisms underlying kidney development and function using zebrafish as a model. We are also interested in creating zebrafish models of human kidney diseases and using these to discover new drug targets. Other areas of interest are endothelial cell biology, angiogenesis and understanding the regulation of gene expression during embryogenesis. We use genome editing techniques (CRISPR and TALEN), zebrafish transgenesis and a range of functional assays and imaging techniques in our research.

Details

The focus of our laboratory is to understand how organs develop during embryogenesis. The organogenesis requires precise coordination of multiple biological processes including cell division, differentiation and migration regulated by well-orchestrated processes at the molecular level such as transcription factor activity, cell-to-cell communication, biochemical process and changes in cell architecture, among others.

By studying developmental processes in the embryo, we aim to gain insights into how normal physiological functions are coordinated in adult tissues. Ultimately, this knowledge will help us better understand disease biology, where these cellular and molecular processes become dysregulated.

In particular, we are investigating the molecular mechanisms underlying kidney development and function using zebrafish as a model. We are also interested in creating zebrafish models of human kidney diseases and using these to discover new drug targets. Other areas of interest are endothelial cell biology, angiogenesis and understanding the regulation of gene expression during embryogenesis. We use genome editing techniques (CRISPR and TALEN), zebrafish transgenesis and a range of functional assays and imaging techniques in our research.

Publications

Details
PubMed Google Scholar 2026 45. Palo A, Mohapatra T, Singh A, Shithij T, Mohanty S, Swain RK, Dixit M. FRG1 Regulates Nonsense-Mediated mRNA Decay by Modulating UPF1 Levels. eLife 2026. In Press 44. Behera A, Datta S, Mohanty S, Mohapatra P, Ansari SA, Podder S, Rath R, Muduly DK, Swain RK, Raghav SK, Dash R. Single-cell analysis identifies BASP1 as a driver of drug resistance and cell plasticity in oral squamous cell carcinoma. J Biol Chem. 2026 Jan 6:111126. doi: 10.1016/j.jbc.2025.111126. PMID: 41506484 2025 43. Nayak U, Sahoo K, Barrodia P and Swain RK. Cfap300 regulates the transdifferentiation of Corpuscle of Stannius cells in zebrafish. bioRXiv 2025. doi: https://doi.org/10.1101/2025.10.06.680176 42. Keshry SS, Nayak U, Mamidi P, Mohanty S, Ghorai U, Swain RK, Chattopadhyay S. CRISPR induced mutations of mk2b and mk3 host proteins enhance Chikungunya virus susceptibility and modulate host immune responses in zebrafish. FASEB J. 2025 Oct 31;39(20):e71112. doi: 10.1096/fj.202501236RR. PMID: 41117602 Joint corresponding authors. 41. Ansari SA, Mohanty S, Mohapatra P, Datta S, Swain M, Rath R, Muduly DK, Majumdar SKD, Swain RK, Raghav SK, Dash R. NEK9-mediated Wnt signalling repressor TLE3 rewires docetaxel resistance in cancer cells by inducing pyroptosis. Br J Cancer.* 2025 Nov;133(10):1428-1440. doi: 10.1038/s41416-025-03148-5. PMID: 40926063 40. Chakraborty G, Anand S, Sahoo K, Ichageri A, Patra C, Swain RK. 3D bioprinted models for antiangiogenic drug screening and validation. 3D Bioprinting in Cancer Applications. Fahima Dilnawaz, Tripti Sharma, Sanjeeb K. Sahoo and Shantibhusan Senapati Etd. Academic Press, ISBN 978-0-443-26518-1. Pg. 209-236. https://doi.org/10.1016/B978-0-443-26518-1.00009-4 2024 39. Sa P, Singh P, Panda S, Swain RK, Dash R, Sahoo SK. Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway. Transl Res. 2024 Jun;268:63-78. doi: 10.1016/j.trsl.2024.03.004. PMID: 38499286 2023 38. Singh P, Sen K, Sa P, Khuntia A, Raghav SK, Swain RK, Sahoo SK. Piperlongumine based nanomedicine impairs glycolytic metabolism in triple negative breast cancer stem cells through modulation of GAPDH & FBP1. Phytomedicine 2024 Jan;123:155181. doi: 10.1016/j.phymed.2023.155181. PMID: 38091824 37. Mohapatra P, Madhulika S, Behera S, Singh P, Sa P, Prasad P, Swain RK, Sahoo SK. Nimbolide-based nanomedicine inhibits breast cancer stem-like cells by epigenetic reprogramming of DNMTs-SFRP1-Wnt/β-catenin signaling axis. Mol Ther Nucleic Acids. 2023 Sep;34:102031. doi: 10.1016/j.omtn.2023.102031. 36. Halder S, Thakur A, Keshry SS, Jana P, Karothia D, Das Jana I, Acevedo O, Swain RK, Mondal A, Chattopadhyay S, Jayaprakash V, Dev A. SELEX based aptamers with diagnostic and entry inhibitor therapeutic potential for SARS-CoV-2. Sci Rep. 2023 Sep;13(1):14560. doi: 10.1038/s41598-023-41885-w. PMID: 37666993 35. Dutta RP, Kumar R, Tembhare PR, Bagal B, Swain RK, Hasan SK. Targeting transcriptional kinase of CDK7 halts proliferation of multiple myeloma cells by modulating the function of canonical NF-kB pathway and cell cycle regulatory proteins. Transl Oncol. 2023 Sep;35:101729. doi: 10.1016/j.tranon.2023.101729. PMID:37369156 2022 34. Mohanty S, Mohapatra P, Shriwas O, Ansari SA, Priyadarshini M, Priyadarsini S, Rath R, Sultania M, Das Majumdar SK, Swain RK, Dash R. CRISPR-based kinome-screening revealed MINK1 as a druggable player to rewire 5FU-resistance in OSCC through AKT/MDM2/p53 axis. Oncogene 2022 Nov;41(45):4929-4940. doi: 10.1038/s41388-022-02475-8. PMID: 36182968 33. Mohapatra P, Mohanty S, Ansari SA, Shriwas O, Ghosh A, Rath R, Majumdar SKD, Swain RK, Raghav SK, Dash R. CMTM6 attenuates cisplatin-induced cell death in OSCC by regulating AKT/c-Myc-driven ribosome biogenesis. FASEB J. 2022 Oct;36(10):e22566. doi: 10.1096/fj.202200808RR. PMID: 36165231 32. Mohapatra AP, Parida D, Mohapatra D, Nayak U, Swain RK, Senapati S. Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors. J Vis Exp. 2022 Aug;(186). doi: 10.3791/64233. PMID: 36094281 31. Prasad P, Mahapatra S, Mishra R, Murmu KC, Aggarwal S, Sethi M, Mohapatra P, Ghosh A, Yadav R, Dodia H, Ansari SA, De S, Singh D, Suryawanshi A, Dash R, Senapati S, Beuria TK, Chattopadhyay S, Syed GH, Swain R, Raghav SK, Parida A (2022). Long-read 16S-seq reveals nasopharynx microbial dysbiosis and enrichment of Mycobacterium and Mycoplasma in COVID-19 patients: a potential source of co-infection. Mol Omics. 2022Jul 11; 18(6):490-505. doi: 10.1039/d2mo00044j. PMID: 35506682 2021 30. Sengupta S, Bhattacharya G, Chatterjee S, Datey A, Shaw SK, Suranjika S, Nath P, Barik PK, Prasad P, Chattopadhyay S, Swain RK, Parida A, Devadas S. Underlying Co-Morbidity Reveals Unique Immune Signatures in Type II Diabetes Patients Infected With SARS-CoV2. Front Immunol. 2022 Apr;13:848335. doi: 10.3389/fimmu.2022.848335. PMID: 35572555 29. Singh B, Avula K, Chatterjee S, Datey A, Ghosh A, De S, Keshry SS, Ghosh S, Suryawanshi AR, Dash R, Senapati S, Beuria TK, Prasad P, Raghav S, Swain R, Parida A, Hussain Syed G, Chattopadhyay S. Isolation and Characterization of Five Severe Acute Respiratory Syndrome Coronavirus 2 Strains of Different Clades and Lineages Circulating in Eastern India. Front Microbiol. 2022 Jun 30; 13:856913. doi: 10.3389/fmicb.2022.856913. PMID: 35847066 28. Mohapatra D, Das B, Suresh V, Parida D, Minz AP, Nayak U, Mohapatra AP, Swain RK, Senapati S (2022). Fluvastatin sensitizes pancreatic cancer cells toward radiation therapy and suppresses radiation- and/or TGF-β-induced tumor-associated fibrosis. Lab Invest. 2022 Mar; 102(3):298-311. doi: 10.1038/s41374-021-00690-7. PMID: 34773069 27. Sen K, Datta S, Ghosh A, Jha A, Ahad A, Chatterjee S, Suranjika S, Sengupta S, Bhattacharya G, Shriwas O, Avula K, Kshatri J, Prasad P, Swain R, Parida AK, Raghav SK (2021). Single-Cell Immunogenomic Approach Identified SARS-CoV-2 Protective Immune Signatures in Asymptomatic Direct Contacts of COVID-19 Cases. Front Immunol. 2021 Nov 25; 12:733539. doi: 10.3389/fimmu.2021.733539. PMID: 34899693 26. Chatterjee S, Datey A, Sengupta S, Ghosh A, Jha A, Walia S, Singh S, Suranjika S, Bhattacharya G, Laha E, Keshry SS, Ray A, Pani SS, Suryawanshi AR, Dash R, Senapati S, Beuria TK, Syed GH, Prasad P, Raghav SK, Devadas S, Swain RK, Chattopadhyay S, Parida A. Clinical, Virological, Immunological, and Genomic Characterization of Asymptomatic and Symptomatic Cases With SARS-CoV-2 Infection in India. Front Cell Infect Microbiol. 2021 Dec 21; 11:725035. doi: 10.3389/fcimb.2021.725035. PMID: 34993157 25. Fatma S, Kumar R, Dixit A, Swain RK. Expression of two uncharacterized protein coding genes in zebrafish lateral line system. Int J Dev Biol. 2021; 65(10-11-12):563-570. doi: 10.1387/ijdb.210066rs. PMID: 34881803 24. Fatma S, Nayak U, Swain RK (2021). Methods to generate and evaluate zebrafish models of human kidney diseases. Int J Dev Biol. 2021; 65(7-8-9):475-485. doi: 10.1387/ijdb.210041rs. PMID: 34549799 23. Dhanagovind PT, Kujur PK, Swain RK, Banerjee S. IL-6 Signaling Protects Zebrafish Larvae during Staphylococcus epidermidisInfection in a Bath Immersion Model. J Immunol. 2021 Oct;207(8):2129-2142. doi: 10.4049/jimmunol.2000714. PMID: 34544800 22. Ramesh ST, Navyasree KV, Sah S, Ashok AB, Qathoon N, Mohanty S, Swain RK, Umasankar PK. BMP2K phosphorylates AP-2 and regulates clathrin-mediated endocytosis. Traffic 2021 Nov;22(11):377-396. doi: 10.1111/tra.12814. 27.PMID: 34480404 21. Barman HK, Mohapatra SD, Chakrapani V, Mondal S, Murmu B, Soren MM, Patra K, Swain RK. Genomic organization and hypoxia inducible factor responsive regulation of teleost hsp90β gene during hypoxia stress. Mol Biol Rep. 2021 Sep; 48(9):6491-6501. doi: 10.1007/s11033-021-06657-7. PMID: 34460062 20. Suresh V, Mohanty V, Avula K, Ghosh A, Singh B, Reddy RK, Parida D, Suryawanshi AR, Raghav SK, Chattopadhyay S, Prasad P, Swain RK, Dash R, Parida A, Syed GH, Senapati S. Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host factors having implication in the disease pathogenesis and severity. FASEB J. 2021 Jul; 35(7):e21713. doi: 10.1096/fj.202100431R. PMID: 34105201 19. Kolapalli SP, Sahu R, Chauhan NR, Jena KK, Mehto S, Das SK, Jain A, Rout M, Dash R, Swain RK, Lee DY, Rusten TE, Chauhan S, Chauhan S. RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression. Cancer Res. 2021 Jan 15; 81(2):315-331. doi: 10.1158/0008-5472.CAN-20-1871. PMID: 33067265 2010 – 2020 18. Raghav S, Ghosh A, Turuk J, Kumar S, Jha A, Madhulika S, Priyadarshini M, Biswas VK, Shyamli PS, Singh B, Singh N, Singh D, Datey A, Avula K, Smita S, Sabat J, Bhattacharya D, Kshatri JS, Vasudevan D, Suryawanshi A, Dash R, Senapati S, Beuria TK, Swain R, Chattopadhyay S, Syed GH, Dixit A, Prasad P; Odisha COVID-19 Study Group; ILS COVID-19 Team; Pati S, Parida A. Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity. Front Microbiol. 2020 Nov 23; 11:594928. doi: 10.3389/fmicb.2020.594928. PMID: 33329480 17. Borah S, Vasudevan D, Swain RK. C-type lectin family XIV members and angiogenesis. Oncol Lett. 2019Oct; 18(4):3954-3962. doi: 10.3892/ol.2019.10760. PMID: 31579078 16. Barrodia P, Patra C, Swain RK. EF-hand domain containing 2 (Efhc2) is crucial for distal segmentation of pronephros in zebrafish. Cell Biosci. 2018 Oct 16; 8:53. doi: 10.1186/s13578-018-0253-z. PMID: 30349665 15. Mohanty M., Mohanty R.C., Mohanty R, Swain R. Human Papilloma Virus 16 and 18 Association in Cervical Intraepithelial Lesions and Cervical Cancers by In Situ Hybridization. International Journal of Medical Research & Health Sciences 2017; 6(3): 41-47. 14. Noy PJ, Swain RK, Khan K, Lodhia P, Bicknell R. Sprouting angiogenesis is regulated by shedding of the C-type lectin family 14, member A (CLEC14A) ectodomain, catalyzed by rhomboid-like 2 protein (RHBDL2). FASEB J. 2016 Jun; 30(6):2311-23. doi: 10.1096/fj.201500122R. PMID: 26939791 13. Borah S, Barrodia P, Swain RK. Nucleolar protein 4-like has a complex expression pattern in zebrafish embryos. Int J Dev Biol. 2016; 60(1-3):53-6. doi: 10.1387/ijdb.150307rs. PMID: 26934290 12. Gorny AK, Kaufmann LT, Swain RK, Steinbeisser H. A secreted splice variant of the Xenopus frizzled-4 receptor is a biphasic modulator of Wnt signalling. Cell Commun Signal. 2013 Nov 19; 11:89. doi: 10.1186/1478-811X-11-89. PMID: 24252524 11. Hetheridge C, Scott AN, Swain RK, Copeland JW, Higgs HN, Bicknell R, Mellor H. The formin FMNL3 is a cytoskeletal regulator of angiogenesis. J Cell Sci. 2012 Mar 15; 125(Pt 6):1420-1428. doi: 10.1242/jcs.091066. PMID: 22275430 10. Hou JM, Krebs MG, Lancashire L, Sloane R, Backen A, Swain RK, Priest LJ, Greystoke A, Zhou C, Morris K, Ward T, Blackhall FH, Dive C. Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer. J Clin Oncol. 2012 Feb 10; 30(5):525-532. doi: 10.1200/JCO.2010.33.3716. PMID: 22253462 09. Mura M, Swain RK, Zhuang X, Vorschmitt H, Reynolds G, Durant S, Beesley JF, Herbert JM, Sheldon H, Andre M, Sanderson S, Glen K, Luu NT, McGettrick HM, Antczak P, Falciani F, Nash GB, Nagy ZS, Bicknell R. Identification and angiogenic role of the novel tumor endothelial marker CLEC14A. Oncogene 2012 Jan 19; 31(3):293-305. doi: 10.1038/onc.2011.233. PMID: 21706054 Before 2010 08. Verissimo AR, Herbert JM, Heath VL, Legg JA, Sheldon H, Andre M, Swain RK, Bicknell R. Functionally defining the endothelial transcriptome, from Robo4 to ECSCR. Biochem Soc Trans. 2009 Dec; 37(Pt 6):1214-7. doi: 10.1042/BST0371214. PMID: 19909249 07. Steinbeisser H, Swain RK. Wnt-frizzled interactions in Xenopus. Methods Mol Biol. 2008; 469:451-463. doi: 10.1007/978-1-60327-469-2_28. PMID: 19109725 06. Vincan E, Swain RK, Brabletz T, Steinbeisser H. Frizzled7 dictates embryonic morphogenesis: implications for colorectal cancer progression. Front Biosci. 2007 May 1; 12:4558-4567. doi: 10.2741/2410.PMID: 17485397 05. Swain RK, Katoh M, Medina A, Steinbeisser H. Xenopus frizzled-4S, a splicing variant of Xfz4 is a context-dependent activator and inhibitor of Wnt/beta-catenin signaling. Cell Commun Signal. 2005 Oct 19; 3:12. doi: 10.1186/1478-811X-3-12. PMID: 16236168 04. Medina A, Swain RK, Kuerner KM, Steinbeisser H. Xenopus paraxial protocadherin has signaling functions and is involved in tissue separation. EMBO J. 2004 Aug 18; 23(16):3249-3258. doi: 10.1038/sj.emboj.7600329. PMID: 15272309 03. Winklbauer R, Medina A, Swain RK, Steinbeisser H. Frizzled-7 signalling controls tissue separation during Xenopus gastrulation. Nature 2001 Oct 25; 413(6858):856-860. doi: 10.1038/35101621. PMID: 11677610 02. Swain RK, Medina A, Steinbeisser H. Functional analysis of the Xenopus frizzled 7 protein domains using chimeric receptors. Int J Dev Biol. 2001;45(1):259-64. PMID: 11291855 01. Ralhan R, Swain RK, Agarwal S, Kaur J, Nath N, Sarkar G, Mathur M, Shukla NK. P-glycoprotein is positively correlated with p53 in human oral pre-malignant and malignant lesions and is associated with poor prognosis. Int J Cancer 1999 Feb 19;84(1):80-85. doi: 10.1002/(sici)1097-0215(19990219)84:1<80::aid-ijc15>3.0.co;2-g. PMID: 9988237

Details

PubMed Google Scholar

2026

45. Palo A, Mohapatra T, Singh A, Shithij T, Mohanty S, Swain RK, Dixit M. FRG1 Regulates Nonsense-Mediated mRNA Decay by Modulating UPF1 Levels. eLife 2026. In Press

44. Behera A, Datta S, Mohanty S, Mohapatra P, Ansari SA, Podder S, Rath R, Muduly DK, Swain RK, Raghav SK, Dash R. Single-cell analysis identifies BASP1 as a driver of drug resistance and cell plasticity in oral squamous cell carcinoma. J Biol Chem. 2026 Jan 6:111126. doi: 10.1016/j.jbc.2025.111126. PMID: 41506484

2025

43. Nayak U, Sahoo K, Barrodia P and Swain RK. Cfap300 regulates the transdifferentiation of Corpuscle of Stannius cells in zebrafish. bioRXiv 2025.
doi: https://doi.org/10.1101/2025.10.06.680176

42. Keshry SS, Nayak U, Mamidi P, Mohanty S, Ghorai U, Swain RK*, Chattopadhyay S*. CRISPR induced mutations of mk2b and mk3 host proteins enhance Chikungunya virus susceptibility and modulate host immune responses in zebrafish. FASEB J. 2025 Oct 31;39(20):e71112. doi: 10.1096/fj.202501236RR. PMID: 41117602 *Joint corresponding authors.

41. Ansari SA, Mohanty S, Mohapatra P, Datta S, Swain M, Rath R, Muduly DK, Majumdar SKD, Swain RK, Raghav SK, Dash R. NEK9-mediated Wnt signalling repressor TLE3 rewires docetaxel resistance in cancer cells by inducing pyroptosis. Br J Cancer. 2025 Nov;133(10):1428-1440. doi: 10.1038/s41416-025-03148-5. PMID: 40926063

40. Chakraborty G, Anand S, Sahoo K, Ichageri A, Patra C, Swain RK. 3D bioprinted models for antiangiogenic drug screening and validation. 3D Bioprinting in Cancer Applications. Fahima Dilnawaz, Tripti Sharma, Sanjeeb K. Sahoo and Shantibhusan Senapati Etd. Academic Press, ISBN 978-0-443-26518-1. Pg. 209-236.
https://doi.org/10.1016/B978-0-443-26518-1.00009-4

2024

39. Sa P, Singh P, Panda S, Swain RK, Dash R, Sahoo SK. Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway. Transl Res. 2024 Jun;268:63-78. doi: 10.1016/j.trsl.2024.03.004. PMID: 38499286

2023

38. Singh P, Sen K, Sa P, Khuntia A, Raghav SK, Swain RK, Sahoo SK. Piperlongumine based nanomedicine impairs glycolytic metabolism in triple negative breast cancer stem cells through modulation of GAPDH & FBP1. Phytomedicine 2024 Jan;123:155181. doi: 10.1016/j.phymed.2023.155181. PMID: 38091824

37. Mohapatra P, Madhulika S, Behera S, Singh P, Sa P, Prasad P, Swain RK, Sahoo SK. Nimbolide-based nanomedicine inhibits breast cancer stem-like cells by epigenetic reprogramming of DNMTs-SFRP1-Wnt/β-catenin signaling axis. Mol Ther Nucleic Acids. 2023 Sep;34:102031. doi: 10.1016/j.omtn.2023.102031.

36. Halder S, Thakur A, Keshry SS, Jana P, Karothia D, Das Jana I, Acevedo O, Swain RK, Mondal A, Chattopadhyay S, Jayaprakash V, Dev A. SELEX based aptamers with diagnostic and entry inhibitor therapeutic potential for SARS-CoV-2. Sci Rep. 2023 Sep;13(1):14560. doi: 10.1038/s41598-023-41885-w. PMID: 37666993

35. Dutta RP, Kumar R, Tembhare PR, Bagal B, Swain RK, Hasan SK. Targeting transcriptional kinase of CDK7 halts proliferation of multiple myeloma cells by modulating the function of canonical NF-kB pathway and cell cycle regulatory proteins. Transl Oncol. 2023 Sep;35:101729. doi: 10.1016/j.tranon.2023.101729. PMID:37369156

2022

34. Mohanty S, Mohapatra P, Shriwas O, Ansari SA, Priyadarshini M, Priyadarsini S, Rath R, Sultania M, Das Majumdar SK, Swain RK, Dash R. CRISPR-based kinome-screening revealed MINK1 as a druggable player to rewire 5FU-resistance in OSCC through AKT/MDM2/p53 axis. Oncogene 2022 Nov;41(45):4929-4940. doi: 10.1038/s41388-022-02475-8. PMID: 36182968

33. Mohapatra P, Mohanty S, Ansari SA, Shriwas O, Ghosh A, Rath R, Majumdar SKD, Swain RK, Raghav SK, Dash R. CMTM6 attenuates cisplatin-induced cell death in OSCC by regulating AKT/c-Myc-driven ribosome biogenesis. FASEB J. 2022 Oct;36(10):e22566. doi: 10.1096/fj.202200808RR. PMID: 36165231

32. Mohapatra AP, Parida D, Mohapatra D, Nayak U, Swain RK, Senapati S. Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors. J Vis Exp. 2022 Aug;(186). doi: 10.3791/64233. PMID: 36094281

31. Prasad P, Mahapatra S, Mishra R, Murmu KC, Aggarwal S, Sethi M, Mohapatra P, Ghosh A, Yadav R, Dodia H, Ansari SA, De S, Singh D, Suryawanshi A, Dash R, Senapati S, Beuria TK, Chattopadhyay S, Syed GH, Swain R, Raghav SK, Parida A (2022). Long-read 16S-seq reveals nasopharynx microbial dysbiosis and enrichment of Mycobacterium and Mycoplasma in COVID-19 patients: a potential source of co-infection. Mol Omics. 2022Jul 11; 18(6):490-505. doi: 10.1039/d2mo00044j. PMID: 35506682

2021

30. Sengupta S, Bhattacharya G, Chatterjee S, Datey A, Shaw SK, Suranjika S, Nath P, Barik PK, Prasad P, Chattopadhyay S, Swain RK, Parida A, Devadas S. Underlying Co-Morbidity Reveals Unique Immune Signatures in Type II Diabetes Patients Infected With SARS-CoV2. Front Immunol. 2022 Apr;13:848335. doi: 10.3389/fimmu.2022.848335. PMID: 35572555

29. Singh B, Avula K, Chatterjee S, Datey A, Ghosh A, De S, Keshry SS, Ghosh S, Suryawanshi AR, Dash R, Senapati S, Beuria TK, Prasad P, Raghav S, Swain R, Parida A, Hussain Syed G, Chattopadhyay S. Isolation and Characterization of Five Severe Acute Respiratory Syndrome Coronavirus 2 Strains of Different Clades and Lineages Circulating in Eastern India. Front Microbiol. 2022 Jun 30; 13:856913. doi: 10.3389/fmicb.2022.856913. PMID: 35847066

28. Mohapatra D, Das B, Suresh V, Parida D, Minz AP, Nayak U, Mohapatra AP, Swain RK, Senapati S (2022). Fluvastatin sensitizes pancreatic cancer cells toward radiation therapy and suppresses radiation- and/or TGF-β-induced tumor-associated fibrosis. Lab Invest. 2022 Mar; 102(3):298-311. doi: 10.1038/s41374-021-00690-7. PMID: 34773069

27. Sen K, Datta S, Ghosh A, Jha A, Ahad A, Chatterjee S, Suranjika S, Sengupta S, Bhattacharya G, Shriwas O, Avula K, Kshatri J, Prasad P, Swain R, Parida AK, Raghav SK (2021). Single-Cell Immunogenomic Approach Identified SARS-CoV-2 Protective Immune Signatures in Asymptomatic Direct Contacts of COVID-19 Cases. Front Immunol. 2021 Nov 25; 12:733539. doi: 10.3389/fimmu.2021.733539. PMID: 34899693

26. Chatterjee S, Datey A, Sengupta S, Ghosh A, Jha A, Walia S, Singh S, Suranjika S, Bhattacharya G, Laha E, Keshry SS, Ray A, Pani SS, Suryawanshi AR, Dash R, Senapati S, Beuria TK, Syed GH, Prasad P, Raghav SK, Devadas S, Swain RK, Chattopadhyay S, Parida A. Clinical, Virological, Immunological, and Genomic Characterization of Asymptomatic and Symptomatic Cases With SARS-CoV-2 Infection in India. Front Cell Infect Microbiol. 2021 Dec 21; 11:725035. doi: 10.3389/fcimb.2021.725035. PMID: 34993157

25. Fatma S, Kumar R, Dixit A, Swain RK. Expression of two uncharacterized protein coding genes in zebrafish lateral line system. Int J Dev Biol. 2021; 65(10-11-12):563-570. doi: 10.1387/ijdb.210066rs. PMID: 34881803

24. Fatma S, Nayak U, Swain RK (2021). Methods to generate and evaluate zebrafish models of human kidney diseases. Int J Dev Biol. 2021; 65(7-8-9):475-485. doi: 10.1387/ijdb.210041rs. PMID: 34549799

23. Dhanagovind PT, Kujur PK, Swain RK, Banerjee S. IL-6 Signaling Protects Zebrafish Larvae during Staphylococcus epidermidisInfection in a Bath Immersion Model. J Immunol. 2021 Oct;207(8):2129-2142. doi: 10.4049/jimmunol.2000714. PMID: 34544800

22. Ramesh ST, Navyasree KV, Sah S, Ashok AB, Qathoon N, Mohanty S, Swain RK, Umasankar PK. BMP2K phosphorylates AP-2 and regulates clathrin-mediated endocytosis. Traffic 2021 Nov;22(11):377-396. doi: 10.1111/tra.12814. 27.PMID: 34480404

21. Barman HK, Mohapatra SD, Chakrapani V, Mondal S, Murmu B, Soren MM, Patra K, Swain RK. Genomic organization and hypoxia inducible factor responsive regulation of teleost hsp90β gene during hypoxia stress. Mol Biol Rep. 2021 Sep; 48(9):6491-6501. doi: 10.1007/s11033-021-06657-7. PMID: 34460062

20. Suresh V, Mohanty V, Avula K, Ghosh A, Singh B, Reddy RK, Parida D, Suryawanshi AR, Raghav SK, Chattopadhyay S, Prasad P, Swain RK, Dash R, Parida A, Syed GH, Senapati S. Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host factors having implication in the disease pathogenesis and severity. FASEB J. 2021 Jul; 35(7):e21713. doi: 10.1096/fj.202100431R. PMID: 34105201

19. Kolapalli SP, Sahu R, Chauhan NR, Jena KK, Mehto S, Das SK, Jain A, Rout M, Dash R, Swain RK, Lee DY, Rusten TE, Chauhan S, Chauhan S. RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression. Cancer Res. 2021 Jan 15; 81(2):315-331. doi: 10.1158/0008-5472.CAN-20-1871. PMID: 33067265

2010 – 2020

18. Raghav S, Ghosh A, Turuk J, Kumar S, Jha A, Madhulika S, Priyadarshini M, Biswas VK, Shyamli PS, Singh B, Singh N, Singh D, Datey A, Avula K, Smita S, Sabat J, Bhattacharya D, Kshatri JS, Vasudevan D, Suryawanshi A, Dash R, Senapati S, Beuria TK, Swain R, Chattopadhyay S, Syed GH, Dixit A, Prasad P; Odisha COVID-19 Study Group; ILS COVID-19 Team; Pati S, Parida A. Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity. Front Microbiol. 2020 Nov 23; 11:594928. doi: 10.3389/fmicb.2020.594928. PMID: 33329480

17. Borah S, Vasudevan D, Swain RK. C-type lectin family XIV members and angiogenesis. Oncol Lett. 2019Oct; 18(4):3954-3962. doi: 10.3892/ol.2019.10760. PMID: 31579078

16. Barrodia P, Patra C, Swain RK. EF-hand domain containing 2 (Efhc2) is crucial for distal segmentation of pronephros in zebrafish. Cell Biosci. 2018 Oct 16; 8:53. doi: 10.1186/s13578-018-0253-z. PMID: 30349665

15. Mohanty M., Mohanty R.C., Mohanty R, Swain R. Human Papilloma Virus 16 and 18 Association in Cervical Intraepithelial Lesions and Cervical Cancers by In Situ Hybridization. International Journal of Medical Research & Health Sciences 2017; 6(3): 41-47.

14. Noy PJ, Swain RK, Khan K, Lodhia P, Bicknell R. Sprouting angiogenesis is regulated by shedding of the C-type lectin family 14, member A (CLEC14A) ectodomain, catalyzed by rhomboid-like 2 protein (RHBDL2). FASEB J. 2016 Jun; 30(6):2311-23. doi: 10.1096/fj.201500122R. PMID: 26939791

13. Borah S, Barrodia P, Swain RK. Nucleolar protein 4-like has a complex expression pattern in zebrafish embryos. Int J Dev Biol. 2016; 60(1-3):53-6.
doi: 10.1387/ijdb.150307rs. PMID: 26934290

12. Gorny AK, Kaufmann LT, Swain RK, Steinbeisser H. A secreted splice variant of the Xenopus frizzled-4 receptor is a biphasic modulator of Wnt signalling. Cell Commun Signal. 2013 Nov 19; 11:89. doi: 10.1186/1478-811X-11-89. PMID: 24252524

11. Hetheridge C, Scott AN, Swain RK, Copeland JW, Higgs HN, Bicknell R, Mellor H. The formin FMNL3 is a cytoskeletal regulator of angiogenesis. J Cell Sci. 2012 Mar 15; 125(Pt 6):1420-1428. doi: 10.1242/jcs.091066. PMID: 22275430

10. Hou JM, Krebs MG, Lancashire L, Sloane R, Backen A, Swain RK, Priest LJ, Greystoke A, Zhou C, Morris K, Ward T, Blackhall FH, Dive C. Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer. J Clin Oncol. 2012 Feb 10; 30(5):525-532. doi: 10.1200/JCO.2010.33.3716. PMID: 22253462

09. Mura M, Swain RK, Zhuang X, Vorschmitt H, Reynolds G, Durant S, Beesley JF, Herbert JM, Sheldon H, Andre M, Sanderson S, Glen K, Luu NT, McGettrick HM, Antczak P, Falciani F, Nash GB, Nagy ZS, Bicknell R. Identification and angiogenic role of the novel tumor endothelial marker CLEC14A. Oncogene 2012 Jan 19; 31(3):293-305. doi: 10.1038/onc.2011.233. PMID: 21706054

Before 2010

08. Verissimo AR, Herbert JM, Heath VL, Legg JA, Sheldon H, Andre M, Swain RK, Bicknell R. Functionally defining the endothelial transcriptome, from Robo4 to ECSCR. Biochem Soc Trans. 2009 Dec; 37(Pt 6):1214-7. doi: 10.1042/BST0371214. PMID: 19909249

07. Steinbeisser H, Swain RK. Wnt-frizzled interactions in Xenopus. Methods Mol Biol. 2008; 469:451-463. doi: 10.1007/978-1-60327-469-2_28. PMID: 19109725

06. Vincan E, Swain RK, Brabletz T, Steinbeisser H. Frizzled7 dictates embryonic morphogenesis: implications for colorectal cancer progression. Front Biosci. 2007 May 1; 12:4558-4567. doi: 10.2741/2410.PMID: 17485397

05. Swain RK, Katoh M, Medina A, Steinbeisser H. Xenopus frizzled-4S, a splicing variant of Xfz4 is a context-dependent activator and inhibitor of Wnt/beta-catenin signaling. Cell Commun Signal. 2005 Oct 19; 3:12. doi: 10.1186/1478-811X-3-12. PMID: 16236168

04. Medina A, Swain RK, Kuerner KM, Steinbeisser H. Xenopus paraxial protocadherin has signaling functions and is involved in tissue separation. EMBO J. 2004 Aug 18; 23(16):3249-3258. doi: 10.1038/sj.emboj.7600329. PMID: 15272309

03. Winklbauer R, Medina A, Swain RK, Steinbeisser H. Frizzled-7 signalling controls tissue separation during Xenopus gastrulation. Nature 2001 Oct 25; 413(6858):856-860. doi: 10.1038/35101621. PMID: 11677610

02. Swain RK, Medina A, Steinbeisser H. Functional analysis of the Xenopus frizzled 7 protein domains using chimeric receptors. Int J Dev Biol. 2001;45(1):259-64. PMID: 11291855

01. Ralhan R, Swain RK, Agarwal S, Kaur J, Nath N, Sarkar G, Mathur M, Shukla NK. P-glycoprotein is positively correlated with p53 in human oral pre-malignant and malignant lesions and is associated with poor prognosis. Int J Cancer 1999 Feb 19;84(1):80-85. doi: 10.1002/(sici)1097-0215(19990219)84:1<80::aid-ijc15>3.0.co;2-g. PMID: 9988237

Group

Details

Postdoctoral Fellow

Dr. Divyanshi Karothia, PhD, Defense Research Development and Establishment (DRDE), Gwalior

Email: dkrothiy[at]gmail[dot]com

Ph.D Students


	Ms. Usharani Nayak, MSc. (Zoology), Fakir Mohan University, Balasore DST – INSPIRE Fellow Email: usharaninayakk14[at]gmail[dot]com
	Ms. Manaswini Rout, MSc. (Botany), Ravenshaw University, Cuttack CSIR – SRF Email: manrout876[at]gmail[dot]com
	Mr. Sanjeev Anand, M.Tech. (Biotechnology), Sardar Vallabh Bhai Patel University of Agriculture and Technology, Meerut Email: sanjeev6jun@gmail.com
	Mr. Deepak Singh CSIR – JRF Email: deepaksingh2495[at]gmail[dot]com

Technicians

Ms. Suryasikha Mohanty, B.Sc. (Chemistry), Rama Devi Womens’ University, Bhubaneswar

Email: kunmunmohanty123[at]gmail[dot]com

Alumni

Dr. Praveen Barrodia, M.Sc. (Biotechnology), University of Rajasthan, Jaipur

PhD Student: September 2012 – November 2018

Current Position: Post-Doctoral Fellow, MD Anderson Cancer Center, Texas, USA

Email: praveenbarrodia[at]gmail[dot]com

Dr. Supriya Borah, M.Sc., University of Agricultural Sciences, Dharwad

PhD Student: February 2013 – October 2019

Current Position: DBT-BioCARe Woman Scientist at CDFD, Hyderabad

Email: layanika[at]gmail[dot]com

Dr. Sana Fatma, M.Sc (Biotechnology), Madurai Kamaraj University, Madurai

PhD Student: September 2016 – April 2022

Current Position: Post-Doctoral Fellow, NIH, USA

Email: fatmasana123[at]gmail[dot]com

Pranita Rout, B.Sc. (Zoology), Kendrapara Autonomous College, Kendrapara

Technician – Dr Amaresh Panda Lab. Institute of Life Sciences

Email: pranita[dot]liza[dot]09[at]gmail[dot]com

Grants

Details
Extramural Grants as PI Mission program on pediatric rare genetic disorders funded by the Department of Biotechnology, MoST, Government of India (2022-2027). Economic empowerment of Tribal Farming communities in one of the Aspirational District of Odisha funded by the Department of Biotechnology, MoST, Government of India (2019-2022). Understanding the development and function of kidney using zebrafish funded by Science and Engineering Research Board, MoST, Government of India (2017-2021). Tumour vascular targeting using small molecule inhibitors funded by the Department of Biotechnology, MoST, Government of India (2015-2018).

Details

Extramural Grants as PI

Mission program on pediatric rare genetic disorders funded by the Department of Biotechnology, MoST, Government of India (2022-2027).

Economic empowerment of Tribal Farming communities in one of the Aspirational District of Odisha funded by the Department of Biotechnology, MoST, Government of India (2019-2022).

Understanding the development and function of kidney using zebrafish funded by Science and Engineering Research Board, MoST, Government of India (2017-2021).

Tumour vascular targeting using small molecule inhibitors funded by the Department of Biotechnology, MoST, Government of India (2015-2018).

Contacts

Email	Address	Fax	Office
rkswain@ils.res.in	Nalco Square, Chandrasekhar Pur, Bhubaneswar-751023, India	0091 674 2300728	(0674) - 2304301 (Office) \|\| 2304312 (Lab)

Highlights

Positions

Details
I always have openings for talented and highly motivated PhD students. I am currently looking to recruit two students for the Monsoon 2026 (June/July) session. Please write to me anytime during the year if you are interested in joining our group. Candidates wishing to join my group as a post-doctoral fellow should be highly motivated, technically accomplished and should be interested in using zebrafish as a model organism to understand human disease biology. Prior experience in molecular biology, developmental biology, cell biology, imaging, genomics, bioinformatics etc. will be considered favourably. Please write to me if you are interested in joining my group and I can sponsor you for various postdoctoral fellowships.

Details

I always have openings for talented and highly motivated PhD students. I am currently looking to recruit two students for the Monsoon 2026 (June/July) session. Please write to me anytime during the year if you are interested in joining our group.

Candidates wishing to join my group as a post-doctoral fellow should be highly motivated, technically accomplished and should be interested in using zebrafish as a model organism to understand human disease biology. Prior experience in molecular biology, developmental biology, cell biology, imaging, genomics, bioinformatics etc. will be considered favourably. Please write to me if you are interested in joining my group and I can sponsor you for various postdoctoral fellowships.

Important Links

Dr. Rajeeb K. Swain

Academics

Work Experience

Awards & Recognition

Research

Publications

Group

Grants

Contacts

Highlights

Positions