Academic Qualification

1. Ph.D. (2005-10): Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, USA
2. B.V.Sc. & A.H. (1996-2002): College of Veterinary Science and Animal Husbandry, OUAT, Odisha, India

Academic and other Positions

1. Scientist-E,  Institute of Life Sciences, Bhubaneswar, Since January 2019
2. Scientist-D,  Institute of Life Sciences, Bhubaneswar, 2015-2018
3. Ramalingaswami Fellow Scientist, Institute of Life Sciences, Bhubaneswar, 2012-2015
4. Postdoctoral Researcher, Ohio State University, Comprehensive cancer center, Columbus, Ohio, USA, 2010-2012
5. Research Assistant, University of Nebraska Medical Center, Omaha, NE, USA, 2005-2010
6. Junior Veterinary Officer, Government Hospital, Kandhamala, Orissa, India 2003- 2005
7. Veterinary Extension Officer, Heifer Project International, Bhubaneswar, India 2002-2003

Academic Awards and Achievements

1. Harris award in cancer research, UNMC, NE, USA, 2010
2. Predoctoral students travel award to attain the AACR meeting, 2009 (Denver, USA)
3. Harris award in cancer research, UNMC, NE, USA, 2009
4. Abstract selected for the oral presentation at the 2008 International Student Forum
5. Student merit scholarship, B.V.Sc, O.U.A.T, India, 1997

Fellowships

1. Ramalingaswami Fellowship, Department of Biotechnology, India, 2012-2017
2. Pelotonia Postdoctoral Fellowship Ohio State University, Comprehensive cancer center Columbus, Ohio, USA , 2011- 2012
3. Predoctoral Prostate Cancer Research Training Award Department of Defense, USA, 2009- 2010
4. University student fellowship UNMC, NE, USA, 2008-2010
5. Research assistantship UNMC, NE, USA, 2005-2008

Broad research activities

• Cancer pathogenesis
• Inflammation and cancer
• Cancer Metastasis

Inflammation plays a major role in cancer pathogenesis, and it could be induced by both infectious and non-infectious agents. Inflammation in tumor microenvironment could have effect on both cancer cells and stromal cells. Currently we are involved in understanding and targeting inflammation and/or infection mediated events in prostate and pancreatic cancer.

Role of bacterial infection in prostate cancer:

Like many other cancers, prostate cancer patients are susceptible to various infections. Numerous in vitro studies have suggested that in addition to stimulating immune cells, bacterial components like LPS/endotoxin could also affect many type of cancer cells through TLR4 signaling. Prostate cancer cells are known to express TLR4 and respond to LPS stimulation in vitro. Activation of TLR4 in cancer cells might have tumor promoting effect by multiple mechanisms. Our preliminary data (unpublished) is suggesting a protumorigenic effect of bacterial components on prostate cancer cells in vitro. We are in the process of validating this observation through a syngeneic orthtotopic rat prostate cancer model. This model has also created an opportunity to examine the efficacy of potential drugs against prostate cancer in vivo. We believe that the ongoing study will elucidate the mechanism behind the effect of bacterial infection on cancer cells. Combined, these studies will provide important insight about the role of infection in cancer promotion, which is an important concern for both the patient and the clinician. Furthermore, knowledge about the mechanistic aspect of endotoxin-induced effect on cancer cells might help in the effective control of cancer progression and treatment.

Understating and targeting pancreatic cancer fibrosis:

Various epidemiological studies have revealed the association of pancreatic cancer with several risk factors including smoking, alcohol consumption, obesity, diabetes, age and family history. All these factors create chronic pancreatitis (inflammation of pancreas). Pancreatic cancer is characterized by a prominent desmoplastic/fibrotic reaction. It is well established that pancreatic stellate cells (PSCs) are the principal source of desmoplasia and interact closely with cancer cells to create a tumor facilitatory micro-environment that stimulates local tumor growth and distant metastasis. Excessive ECM deposition around the tumor cells inhibits the distribution and penetration of anti-cancer drugs by decreasing the tumor vascularity and by constructing physical barriers. Therefore, any drug that could either reduce proliferation of activated PSCs and/or suppress extracellular matrix protein production by them could have potential use in pancreatic cancer associated fibrosis therapy. Our current focus is to establish reliable in vitro and in vivo models that could be exploited to screen and validate potential anti-fibrotic drugs. Our long-term goal is to identify novel anti-fibrotic dugs by drug-repositioning approach, and identify new molecular targets that play major roles in PSCs activation.

Publications from ILS, Bhubaneswar

Original research articles

1. Jain S*, Samal AG* , Das B*, Pradhan B, Sahu N_, Mohapatra D , Behera PK, Satpathi PS, Mohanty AK, Satpathi S, Senapati S. Escherichia coli, a common constituent of benign prostate hyperplasia (BPH)-associated microbiota induces inflammation and DNA damage in prostate epithelial cells. (2020) Prostate. Aug 24. doi: 10.1002/pros.24063
2. Suresh V, Parida D, Minz PA,  Sethi M, Sahoo SB, Senapati S. Tissue distribution of ACE2 protein in Syrian golden hamster (Mesocricetus auratus) and its possible implications in SARS-CoV-2 related studies. Frontiers in Pharmacology (Brief research report, Accepted on 5th Nov 2020)
3. Senapati S,  Kshatri SJ,Prasad P, Turuk J, Pati S, Parida A. A pilot study to investigate the fecal dissemination of SARS-CoV-2 virus genome in COVID-19 patients in Odisha, India. medRxiv 2020.05.26.20113167 (preprint submission)
4. Das, B, Senapati, S. Functional and mechanistic study reveals MAGEA3 as a pro-survival factor in pancreatic cancer cells. (2019) J Exp Clin Cancer Res. Jul 8;38(1):294
5. Suresh V*, Sundaram R*, Dash P*, Sabat SC, Mohapatra D, Mohanty S, Vasudevan D, Senapati S. Macrophage migration inhibitory factor of Syrian golden hamster shares structural and functional similarity with human counterpart and promotes pancreatic cancer. (2019) Scientific Reports 9: 15507.
6. Izhar S, Gupta T, Minz AP, Senapati S, Panday AK. Influence of regional and long range transport air masses on fog water composition, contribution and toxicological response at Indo Gangetic Plain. Atmospheric Environment. Volume 214, 1 October 2019, 116888
7. Guha, D., Banerjee, A,. Mukherjee, R., Pradhan, B., Peneva, M., Aleksandrov, G., Suklabaidya, S., Senapati, S., Aich, P.: A Probiotic formulation containing Lactobacillus bulgaricus DWT1 inhibits tumor growth by activating pro-inflammatory responses in macrophages. Journal of Functional Foods. Volume 56, May 2019, Pages 232-245
8. Jain S, Dash P*, Minz A*, Satpathi S, Samal AG, Behera PK, Satpathi PS, Senapati S. Lipopolysaccharide (LPS) enhances prostate cancer metastasis potentially through NF-κB activation and recurrent dexamethasone administration fails to suppress it in vivo. (2018) Prostate. September 27
9. Jena KK, Kolapalli SP, Mehto S, Nath P, Das B, Sahoo PK, Ahad A, Syed GH, Raghav SK, Senapati S, Chauhan S, Chauhan S. TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. (2018) EMBO J. Aug 24.
10. Patra D, Mukherjee S, Chakraborty I, Dash TK, Senapati S, Bhattacharyya R, and Shunmugam R.Iron(III) Coordinated Polymeric Nanomaterial: A Next-Generation Theranostic Agent for High-Resolution T1-Weighted Magnetic Resonance Imaging and Anticancer Drug Delivery. (2018) ACS Biomater. Sci. Eng. 4 (5), pp 1738–1749
11. Pradhan B, Guha D, Naik AK, Banerjee A, Tambat S, Chawla S, Senapati S, Aich P. Probiotics L. acidophilus and B. clausii Modulate Gut Microbiota in Th1- and Th2-Biased Mice to Ameliorate Salmonella Typhimurium-Induced Diarrhea. (2018) Probiotics Antimicrob Proteins. Jun 16.
12. Katoch A, Suklabaidya S, Chakraborty S, Nayak D, Rasool RU, Sharma D, Mukherjee D, Faheem MM, Kumar A, Sharma PR, Senapati S, Kumar LD, Goswami A. Dual Role of Par-4 in abrogation of EMT and switching on Mesenchymal to Epithelial Transition (MET) in metastatic pancreatic cancer cells. (2018) Mol Carcinog. Apr 19
13. Kumari K, Das B, Adhya A, Chaudhary S, Senapati S, Mishra SK. Nicotine associated breast cancer in smokers is mediated through high level of EZH2 expression which can be reversed by methyltransferase inhibitor DZNepA . (2018) Cell Death Dis. Feb 2;9(2):152
14. Mahapatra P, Jain S, Shrestha S, Senapati S, Puppala S. Ambient endotoxin in PM10 and association with inflammatory activity, air pollutants, and meteorology, in Chitwan, Nepal. (2018) Sci Total Environ. Mar 15;618:1331-1342
15. Suklabaidya S, Das B, Ali SA, Jain S, Swaminathan S, Mohanty AK, Panda SK, Dash P, Chakraborty S, Batra SK, Senapati S. Characterization and use of HapT1-derived homologous tumors as a preclinical model to evaluate therapeutic efficacy of drugs against pancreatic tumor desmoplasia. (2016) Oncotarget. Jul 5;7(27):41825-41842
16. Barman PK, Mukherjee R, Prusty BK, Suklabaidya S, Senapati S, Ravindran B.Chitohexaose protects against acetaminophen-induced hepatotoxicity in mice. (2016) Cell Death & Disease. May 12;7
17. Jain S, Suklabaidya S, Das B, Raghav SK, Batra SK, Senapati S. TLR4 activation by lipopolysaccharide confers survival advantage to growth factor deprived prostate cancer cells. (2015) Prostate. Jul 1;75(10):1020-33.
18. Sarkar S, Jain S, Rai V, Sahoo DK, Raha S, Suklabaidya S, Senapati S, Rangnekar VM, Maiti IB, Dey N. Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4) exhibits growth inhibitory effects in prostate cancer cells. (2015) Front Plant Sci. Oct 7;6:822.
19. Maiti S, Patro S, Purohit S, Jain S, Senapati S, Dey N. Effective control of Salmonella infections by employing combinations of recombinant antimicrobial human β-defensins hBD-1 and hBD-2. (2014) Antimicrob Agents Chemother. Nov;58(11):6896-903.
20. Sahu PK*, Das B*, Sahoo L, Senapati S, Nayak GD. Genetic relationship and population structure of three Indian local chicken populations as revealed by mtDNA D-loop. (2015) Mitochondrial DNA. Jul 10:1-3.
21. Singh A, Jain S, Senapati S, Verma RS and Sahoo SK. Magnetic nanoparticles labeled mesenchymal stem cells: A pragmatic solution towards targeted cancer theranostics. (2015) Advanced Healthcare Materials. Sep 1
22. Pati, S. Jain, M. Behera, A.P. Acharya, S.K. Panda, S. Senapati. X-Gal staining of canine skin tissues: a technique with multiple possible applications. (2014) Journal of Natural Science, Biology and Medicine. July;5:245-249

Reviews and letter to editor

1. Senapati S, Dash J, Sethi M, Chakraborty S (2020) Bioengineered probiotics to control SARS-CoV-2 infection. Research Ideas and Outcomes 6: e54802. https://doi.org/10.3897/rio.6.e54802
2. Das P, Minz A, Senapati S.  Possible autocrine function of galectin-3 in pancreatic stellate cells. Gastroenterology, August 2018
3. Suklabaidya S*, Dash P*, Das B, Suresh V, Sasmal PK, Senapati S. Experimental models of pancreatic cancer desmoplasia. Lab Invest.2018 Jan;98(1):27-40 
4. Suklabaidya S*, Dash P*, Senapati S. Pancreatic fibroblast exosomes regulate survival of cancer cells. Oncogene; 2017 Jun 22;36(25):3648-3649
5. Das B, Suklabaidya S, Jain S, Baisakh MR, Senapati S. MAGEA3 (melanoma antigen family A,3); Atlas Genet Cytogenet Oncol Haematol. April 2014.
6. Senapati S, Chakraborty S, Nath I, Panda SK, Patra RC and Batra SK. Non- Human Prostate Cancer Cell Lines. Oncology, Gastroenterology and Hepatology reports. 2012; 1(1):15-24

Book Chapter

1. Das B and Senapati S. Immunological and functional aspects of MAGEA3 cancer/testis antigen. Advances in Protein Chemistry and Structural Biology Elsevier Inc. June, 2020 (Invited book chapter; Accepted)
2. Senapati S, Singh RK and Batra SK. Tumor microenvironment: Blood vascular system in cancer metastasis. In: Systems Biology of Cancer, Editor: Sam Thiagalingam, Cambridge University Press London

  *Both the authors have equal contributions; Underlined= corresponding author

Extramural funding

Source                                                                       Duration                                                       Role            

DST-SERB                                                                    (2018-2020)                                                PI

DBT                                                                                (2017-2019)                                                PI

DST-SERB                                                                    (2016-2018)                                               Co-PI

Ramalingaswami Fellowship (DBT)                (2012-2017; Completed)                        PI