Scientist E (2017- Present), Institute of Life Sciences, Bhubaneswar
Scientist D (2013 – 2017), Institute of Life Sciences, Bhubaneswar
Scientist C (2009 – 2013), Institute of Life Sciences, Bhubaneswar
Scientist B (2006-2009), Institute of Life Sciences, Bhubaneswar
Lecturer (2006), Institute of Life Sciences, Bhubaneswar
Postdoctoral Fellow (2004-2006), Center for Cellular and Molecular Biology (CCMB), Hyderabad
Honours & Awards
DBT CREST Award 2012-13 (international fellowship), Department of Biotechnology (DBT), Govt. of India.
Felicitated by Dr. T Ramasami, DG CSIR on September 22, 2007 for pioneering contributions for developing a “Diagnostic tool (DNA chip) to identify a number of eye infections”.
Post-Doctoral Fellowship (2005-2006), Department of Biotechnology (DBT), Govt. of India
Post-Doctoral Fellowship (2004-2005), Council of Scientific & Industrial Research (CSIR), Govt. of India
Senior Research Fellowship (2002-2004), Council of Scientific & Industrial Research (CSIR), Govt. of India
Junior & Senior Research Fellowship (1999-2002), Department of Atomic Energy (DAE), Govt. of India
Life Member, Indian Society of Human Genetics (ISHG)
Member, Human Genome Organization (HUGO)
Human/Medical Genetics & Molecular Diagnostics
Genetic and Molecular analysis of inherited disorders, mapping genes, screening mutations, DNA based diagnostics and its application in biomedical problems
Research in our laboratory focuses on the identification, localization (genetic loci) and characterization of genes responsible for the inherited genetic disorders and complex traits in human populations. Our approach for studying these events follows population genetics, linkage-based mapping, molecular genetics and statistical genetics. We utilize different forms of linkage analysis, mutation analysis, genome wide association studies and gene expression studies. The main aim of these studies is to identify the genes that are influenced by variants to predispose to these diseases, and to understand the etiopathogenesis from genetic variation to clinical disease. The long term aim is to transfer this knowledge to applications, such as development of genetic diagnostics and treatments, in humans.
Current projects aimed in our lab
Investigation of the gene expression and characterization of selected genes associated with otosclerosis
Identification of Genetic Susceptibility to Chronic or Recurrent Otitis Media with Effusion
Molecular Genetic studies of congenital hearing impairment
Genetic Analysis of Otosclerosis: Mapping Gene(s) and Screening of Candidate Genes for Mutations
Human/Medical Genetics Publications
Hansdah K, Singh N, Bouzid A, Priyadarshi S, Ray CS, Desai A, Panda KC, Choudhury JC, Biswal NC, Tekari A, Masmoudi S, Ramchander PV. Evaluation of the Genetic Association and mRNA Expression of the COL1A1, BMP2, and BMP4 Genes in the Development of Otosclerosis. Genetic Testing and Molecular Biomarkers. 2020, DOI: 10.1089/gtmb.2019.0235.
Bouzid A, Tekari A, Jbeli F, Chakroun A, Hansdah K, Souissi A, Singh N, Mosrati M, Achour I, Ghorbel A, Charfeddine I, Ramchander PV, Masmoudi S. Osteoprotegerin gene polymorphisms and otosclerosis: an additional genetic association study, multilocus interaction and meta-analysis. BMC Medical Genetics. 2020, DOI: 10.1186/s12881-020-01036-8
Panda KC, Bhuyan L, Ramchander PV. Association of sudden sensorineural hearing loss with chronic periodontitis: a hospital-based study in India. Hearing, Balance and Communication. 2020, DOI: 10.1080/21695717.2020.1719786.
Manohar S, Ramchander PV, Salvi R, Seigel GM. Synaptic Reorganization Response in the Cochlear Nucleus Following Intense Noise Exposure. Neuroscience. 2019, 399:184-198.
Priyadarshi S, Hansdah K, Ray CS, Biswal NC, Ramchander PV. Otosclerosis Associated with a De Novo Mutation −832G>A in the TGFB1 Gene Promoter Causing a Decreased Expression Level. Scientific Reports. 2016, 6: 29572; doi: 10.1038/srep29572
Priyadarshi S, Ray CS, Biswal NC, Nayak SR, Panda KC, Desai A, Ramchander PV. Genetic Association and Altered Gene Expression of Osteoprotegerin in Otosclerosis Patients. Annals of Human Genetics. 2015; DOI: 10.1111/ahg.12118
Priyadarshi S, Panda KC, Ray CS, Desai A, Nayak SR, Biswal NC, Ramchander PV. Genetic association and gene expression analysis of TGFB1 contributes towards the susceptibility to otosclerosis. J Bone Miner Res. 2013; DOI: 10.1002/jbmr.1991.
Padma G, Ramchander PV, Nandur VU, Ravi Kumar K, Padma T: Novel Mutations Affecting the Secondary Structure of MT-RNR1 Gene: A Causal Relationship with Profound Nonsyndromic Hearing Impairment. Genetic Testing and Molecular Biomarkers. 2012, 16: 1092-1097.
Saurabh Priyadarshi, Panda KC, Panda AK, Ramchander PV: Lack of association between the SNP rs3914132 of RELN gene and otosclerosis in India. Genet. Mol. Res. 2010; 9: 1914-1920.
Ramchander PV, Panda KC, Panda AK: Mutations in the Connexin 29 Gene are not a Major cause of Non-syndromic Hearing Impairment in India. Genetic Testing and Molecular Biomarkers. 2010; 14: 539-541.
Padma G, Ramchander PV, Nandur UV, Padma T. A rare event of maternal UPD in a proband with congenital non-syndromic hearing impairment with homozygosity for gjb2 p.w24x mutation. Int. J. Genet. Mol. Biol. 2010; 2: 126-129.
Padma G, Ramchander PV, Nandur UV, Padma T. GJB2 and GJB6 gene mutations found in Indian probands with congenital hearing impairment. J. Genet 2009; 88: 267–272.
Padma G, Padma T, Ramchander PV, Nandur UV. Mitochondrial gene mutations as a cause of non-syndromic hearing impairment among probands from Andhra Pradesh. Genomic Med. 2008; 2: 241–252.
Subramanian Dhivya, Madhavan HN, Rao CM, Rao KS, Ramchander PV, Therese KL, Malathi J. Comparison of a novel semi-nested polymerase chain reaction (PCR) with a uniplex PCR for the detection of Acanthamoeba genome in corneal scrapings. Parasitology Research 2007; 100: 1303-1309.
Ramchander PV, Nandur VU, Dwarakanath K, Vishnupriya S, Padma T: Prevalence of Cx26 gene (GJB2) Mutations Causing Recessive Nonsyndromic Hearing Impairment in India. Int. J Hum Genet. 2005; 5(4): 241-246.
Ramchander PV, Nandur VU, Dwarakanath K, Vishnupriya S, Padma T: Study of Families of Nonsyndromic Hearing Impairment Segregating with mutations in Cx26 gene. Indian J Hum Genet. 2004; 10(2): 58-64.
Patents & Products
Inventors: Mohan Rao Ch, Sridhar Rao K, Ramchander PV, Madhavan HN, Savitri Sharma, Gita Satpathy, Ravi Kumar BV. Title: Method for Simultaneous Detection and Discrimination of Bacterial, Fungal, Parasitic and Viral Infections of Eye and Central Nervous System. United States Patent: US8465951B2, Date of Patent: 18.06.2013 (Granted).
Inventors: Mohan Rao Ch, Sridhar Rao K, Ramchander PV, Madhavan HN, Savitri Sharma, Gita Satpathy, Ravi Kumar BV. Title: A Novel Method for Simultaneous Detection and Discrimination of Bacterial, Fungal, Parasitic and Viral Infections of Eye and Central Nervous System. Patent publication numbers: PCT/IN2008/000334; AR066825A1; N200701178-I1; CN101541979A; AU2008256216A1; EP2155909A2; IL202459D0, NZ582232A; CA2689306A1; KR2010044736A; JP2010528599A; PH12009502297A; VN23743A; TW200907057A (Filed).
Mohan Rao Ch, Sridhar Rao K, Ramchander PV et al: Developed a DNA based diagnostic chip for identifying the pathogens causing eye disease. The technology was transferred to the Xcyton Diagnostics Pvt. Ltd for product development. The same principles and technology can be extended to identification of infecting organisms in other diseases as well.Received ‘2009 BioSingapore Asia Pacific Biotechnology Award’ under the category “Most Important Technology Development”.
Submission of unpublished variants
Ramchander, PV 2013. dbSNP: TGFB1 c.-832G>A; status confirmed ‘rs368915262’
Ramchander, PV 2010. dbSNP: NM_181538.1:c.569T>A_1286185218; status confirmed ‘rs121908693’