Clinical Proteomics & Proteoinformatics

Academic Qualification

1. Ph.D. (Applied Biology): National Institute for Research in Reproductive Health (Indian Council of Medical Research), Mumbai (MS) University of Mumbai.
2. M.V.Sc. (Genetics and Animal Breeding): Bombay Veterinary College, Mumbai Dr. Balasaheb Sawant Konkan Krishi Vidyapeeth, Dapoli (MS).
3. B.V.Sc & A.H (Veterinary Science): Bombay Veterinary College, Mumbai Konkan Krishi Vidyapeeth, Dapoli (MS).

Academic Positions

1. Scientist: Institute of Life Sciences, Bhubaneswar-751023, India
2. Ph.D. Research Scholar: National Institute for Research in Reproductive Health (Indian Council of Medical Research), Mumbai (MS)
3. Scientist: Molecular Diagnostics and Research Centre, Mumbai

Membership of Societies

1. Life Member and Executive Council Member (Since Jan 2013), Proteomics Society of India (PSI)
2. Member, Human Proteome Organization (HUPO)
3. Life Member, Laboratory Animals Scientist Association, India (LASA)
4. Life Member, Society of Biological Chemists, India (SBC)
5. Life Member, Indian Society for Mass Spectrometry (ISMAS)
6. Life Member, Indian Virological Society (IVS)

Clinical Proteomics & Proteoinformatics

Broad research activities

• Bio-marker discovery in various clinical diseases
• To decipher the role of important protein/s in disease pathogenesis
• Identification and characterization of post-translational modifications (PTMs)with respect to their role in disease pathogenesis

My group is working on identifications and Characterization of Bio-markers in various Diseases, identification of PTMs and their role in disease pathogenesis using high through put Mass spectrometry based proteomics approaches. We used various such as gel based, non gel based, labeled, labeled free proteomic appropaches in our experiments.

At present following subareas are mainly focused

• Viral Proteomics
• Serum Proteomics
• Immunoproteomics

Clinical Proteomics & Proteoinformatics

Selected Publications

1. Swaroop S, Sengupta N, Suryawanshi AR, Adlakha YK, Basu A. HSP60 plays a regulatory role in IL-1β-induced microglial inflammation via TLR4-p38 MAPK axis. J Neuroinflammation. 2016 Feb 2;13(1):27. doi: 10.1186/s12974-016-0486-x.
2. Sengupta N, Mukherjee S, Tripathi P, Kumar R, Suryawanshi AR, Basu A. Cerebrospinal Fluid Biomarkers of Japanese Encephalitis [version 2; referees: 3 approved]. F1000Research 2015, 4:334 (doi: 10.12688/f1000research.6801.2)
3. Kumar S, Mamidi P, Kumar A, Basantray I, Bramha U, Dixit A, Maiti PK, Singh S, Suryawanshi AR, Chattopadhyay S, Chattopadhyay S. Development of novel antibodies against non-structural proteins nsP1, nsP3 and nsP4 of chikungunya virus: potential use in basic research. Arch Virol. 2015 Nov;160(11):2749-61. doi: 10.1007/s00705-015-2564-2.
4. Pratheek BM, Suryawanshi AR, Chattopadhyay S, Chattopadhyay S. In silico analysis of MHC-I restricted epitopes of Chikungunya virus proteins: Implication in understanding anti-CHIKV CD8(+) T cell response and advancement of epitope based immunotherapy for CHIKV infection. Infect Genet Evol. 2015 Apr;31:118-26. doi: 10.1016/j.meegid.2015.01.017.
5. Kumar A, Mamidi P, Das I, Nayak TK, Kumar S, Chhatai J, Chattopadhyay S, Suryawanshi AR, Chattopadhyay S. A novel 2006 Indian outbreak strain of chikungunya virus exhibits different pattern of infection as compared to prototype strain. PLoS One. 2014 Jan 20;9(1):e85714. doi: 10.1371/journal.pone.0085714. eCollection 2014 Jan 20.
6. Chattopadhyay S, Kumar A, Mamidi P, Nayak TK, Das I, Chhatai J, Basantray I, Bramha U, Maiti PK, Singh S, Suryawanshi AR, Chattopadhyay S. Development and characterization of monoclonal antibody against non-structural protein-2 of Chikungunya virus and its application. J Virol Methods. 2014 Jan 21;199C: 86-94. doi: 10.1016/j.jviromet.2014.01.008.
7. Joshi CS, Suryawanshi AR, Khan SA, Balasinor NH, Khole VV. Liprin α3: a putative estrogen regulated acrosomal protein. Histochem Cell Biol. 2013 Apr;139 (4):535-48.
8. Suryawanshi AR, Khan SA, Joshi CS, Khole VV. Epididymosome Mediated Acquisition of MMSDH an Androgen Dependent and Developmentally Regulated Epididymal Sperm Protein. J Androl. 2012 Sep-Oct;33(5):963-74.
9. Gajbhiye RK, Sonawani A, Khan SA, Suryawanshi AR, Kadam S, Warty N, Raut V, Khole VV. Identification and validation of novel serum markers for early diagnosis of endometriosis. Hum Reprod. 2012 Feb;27(2):408-17.
10. Khan SA, Jadhav SV, Suryawanshi AR, Bhonde GS, Gajbhiye RK, Khole VV (2011). Evaluation of Contraceptive Potential of a Novel Epididymal Sperm Protein SFP2 in a Mouse Model. Am J Reprod Immunol. 2011 Sep;66(3):185-98.
11. Suryawanshi AR, Khan SA, Gajbhiye RK, Gurav MY, Khole VV (2010). Differential Proteomics Leads to Identification of Domain Specific Epididymal Sperm Proteins. J Androl. 2011; 32(3):240-59.
12. Khan S A*, Suryawanshi A R*, Ranpura S, Jadhav S, Khole V V. (2009). Identification of Novel Immunodominant Epididymal Sperm Proteins using Combinatorial Approach. Reproduction, 2009; 138: 81-93 (*Authors have equally contributed)
13. Gajbhiye R K, Suryawanshi A R, Khan S A, Meherji P K, Warty N R, Raut V S, Chehna N A, Khole V V. (2008). Multiple endometrial antigens are targeted in autoimmune endometriosis. Reprod Biomed Online.; 16 (6):817-24.

Clinical Proteomics & Proteoinformatics

My lab Members:

Present Lab Members:

• Mr. Bijayananda Panigrahi
• Mr. R. Rajendra Kumar Reddy

Clinical Proteomics & Proteoinformatics

Current Projects