Profile
Dr. Indrajit Sahu is a Protein Biochemist and Molecular cell Biologist. He has been working in the Ubiquitin-Proteasome-System (UPS) field since 2010. His research mainly focuses on protein homeostasis in human diseases and development. After finishing his PhD in Cancer Biology at the Advanced Centre for Treatment, Research and Education in Cancer (ACTREC)-Tata Memorial Centre, Navi Mumbai he joined Prof. Michael Glickman at Technion-Israel Institute of Technology, Haifa, for his first Postdoctoral research on protein degradation mechanism. During his tenure at Technion, he received three prestigious Postdoc fellowships (Marie-Curie Individual Fellowship, EU; FEBS short-term Fellowship, EU; and Daniel-Turnburg/Welcome Trust short-term Fellowships, UK). In 2021 he joined Prof. Alfered Goldberg at Harvard Medical School to continue his research on UPS. In 2022, he worked with Prof. Jarrod Marto & Prof. Sara Buhrlage at Dana-Farber Cancer Institute, HMS to learn small molecule drug discovery against deubiquitinase enzyme for cancer.
Current Focus Areas
Ubiquitin-Proteasome System and protein homeostasis in human pathology.
Synthetic modulation of Ubiquitin-Proteasome system for misfolded protein degradation.
Mechanism of Proteasome impairments in human diseases.
Mechanism of DUB function and alteration of ubiquitin landscape.
Selected Publications
Brindhavanam PT, Sahu I*. Decoding the ubiquitin landscape by cutting-edge ubiquitinomic approaches. Biochemical Society Transactions. Apr 2024; 52(2):627-637.
Sahu I#*, Bajorek M#, Osmulski P, Krutauz D, Reis N, Gaczynska M, Glickman M.H*. A unique role for the N-terminus of the alpha-2 subunit in aiding substrate translocation into the catalytic core of the proteasome. Biomolecules. 2023, 3(3), 480.
Sahu I, Mali S.M, Sulkshane P, Morag R, Xu C, Rozenberg A, Sahoo M.P, Singh S.K, Ding Z, Wang Y, Day S, Cong Y, Kleifeld O*, Brik A*, Glickman M.H*. The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag. Nature Communications 2021, 12, 6173.
Sahu I* and Glickman M.H*. “Proteasome in action” – Substrate degradation by the 26S proteasome. Biochemical Society Transactions 2021, 49 (2): 629–644.
Sahu I#, Singh S.K#, Mali S.M, Hemantha H.P, Kleifeld O, Glickman M.H*, and Brik A*. Synthetic uncleavable ubiquitinated proteins dissect proteasome deubiquitination and degradation and highlight distinctive fate of tetraubiquitin. J. Am. Chem. Soc. (2016) Vol. 138, 16004−16015.