Shailendra Mani

Senior Research Scientist, BRIC-THSTI

Profile

Our research focuses on studying the cross-reactivity and co-infection of SARS-CoV-2 with other coronaviruses and endemic viruses such as Dengue and influenza. Our ultimate objective is to gain insights into the interplay between these viruses during co-infection and their impact on the immune response. Additionally, we aim to explore the potential occurrence of Antibody Dependent Enhancement (ADE) in the context of coronaviruses and/or other endemic viruses. By deepening our understanding of these phenomena, we aim to develop effective vaccines and antiviral treatments for SARS-CoV-2, while also shedding light on the varying severity of viral infections among individuals.

Current Focus Areas

  • Understanding cross-reactivity and co-infection of viruses: • SARS—CoV-2 VOCs, • Common Coronaviruses (NL63, 229E, OC43, HKU1), •Dengue(1-4), •Influenza

  • Developing serological tools for public health importance: • Pseudo virus generation and neutralisation assays, • Multiplex-Luminex bead based assay, Developing plug and play vaccine platforms for Disease X

Selected Publications

  • Shao ER, Tan CW, Mani S, Anderson DE, Lwezaula BF, Mmbaga BT, Maro VP, Shen S, Deng F, Halliday JEB, Mendes ÂJ, Madut DB, Cleaveland S, Crump JA, Rubach MP, Wang LF. (January, 2025). Seroprevalence and risk factors for Crimean-Congo hemorrhagic fever virus exposure among febrile patients in northern Tanzania. Trop Med Int Health. doi: 10.1111/tmi.14082.

  • Joshi P, Garg S, Mani S, Shoaib R, Jakhar K, Almuqdadi HTA, Sonar S, Marothia M, Behl A, Biswas S, Singhal J, Kahlon AK, Shevtsov M, Abid M, Garg P, Ranganathan A, Singh S. (August, 2024). Targeting host inducible-heat shock protein 70 with PES-Cl is a promising antiviral strategy against SARS-CoV-2 infection and pathogenesis. Int J Biol Macromol. doi: 10.1016/j.ijbiomac.2024.135069.

  • Di Martino A, Bhattacharyya S, Riccardo F, Pandey R, Chiara M, Mani S, Pezzotti P, Lo Presti A, Ambrosio L, Marziano V, Poletti P, Pesole G, Narayan J, Brijwal M, Choudhary A, Tramuto F, Mazzucco W, Agrawal A, Mohan A, Stefanelli P. The

  • Wang LF, Mani S, Tan CW, Anderson DE. (August, 2023). Assays for Detecting Henipavirus Antibodies. Nipah Virus: Methods and Protocols, 245-258

  • Mani S, Kaur A, Jakhar K, Kumari G, Sonar S, Kumar A, Das S, Kumar S, Kumar V, Kundu R, Pandey AK, Singh UP, Majumdar T. (August, 2023). Targeting DPP4-RBD interactions by sitagliptin and linagliptin delivers a potential host-directed therapy against pan-SARS-CoV-2 infections. International Journal of Biological Macromolecules, 245/125444

  • Sadhu S, Dandotiya J, Dalal R, Khatri R, Mykytyn AZ, Batra A, Kaur M, Chandwaskar R, Singh V, Kamboj A, Srivastava M, Mani S, Asthana S, Samal S, Rizvi ZA, Salunke DB, Haagmans BL, Awasthi A. (December, 2023). Fangchinoline inhibits SARS-CoV-2 and MERS-CoV entry. Antiviral Research, 220/105743

Skills & Proficiency

Cross-reactivity Co-infections Viral Pathogenesis Vaccine Development Luminex platform ADE Dengue Coronavirus Pseudovirus ABSL3
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