Profile
I am a reproductive biologist by training and completed my doctoral research at the National Institute of Immunology, where I investigated the role of Hippo Signalling Pathway in regulating Sertoli cell function and spermatogenesis. At the National Institute of Animal Biotechnology (NIAB), my laboratory examines the mechanistic basis of metabolic and endocrine homeostasis in livestock, with a focus on pesticide-induced metabolic and reproductive dysfunction. Farm animals are often exposed to endocrine-disrupting pesticides through contaminated feed and fodder, can dirupt endocrine and metabolic function leading to fertility defects and reduced productivity. Using integrated in vitro (cell and tissue culture) and in vivo (rodent and small ruminant) models, we dissect the molecular pathways underlying pesticide-induced toxicity. Our current research also explores how such toxicant-induced alterations may have long-term and transgenerational consequences for reproductive and metabolic health of livestock
Current Focus Areas
My laboratory investigates the mechanistic basis of metabolic and endocrine homeostasis in livestock, focusing on the molecular mechanisms by which endocrine-disrupting chemicals impair reproductive and metabolic health. Using in vitro and in vivo models, we study hormonal dysregulation, fertility loss, and transgenerational effects, aiming to improve livestock health and productivity.
Selected Publications
1. Mansukhani, M., Ganguli, N., Majumdar, S. S., & Sen Sharma, S. (2026). Chronic oral exposure to chlorpyrifos disrupts hepatic epigenetic regulation and induces metabolic dysfunction in mice. Toxicology, Volume 519, January 2026, 154296. https://doi.org/10.1016/j.tox.2025.154296
2. Mansukhani, M., Roy, P., Ganguli, N., Majumdar, S. S., & Sen Sharma, S. (2024). Organophosphate pesticide chlorpyrifos and its metabolite 3, 5, 6-trichloropyridinol downregulate the expression of genes essential for spermatogenesis in caprine testes. Pesticide Biochemistry and Physiology, 204, 106065.
3. Sarkar, RK*., Sen Sharma, S*., Mandal, K., Wadhwa, N., Kunj, N., Gupta, A., Pal, R., Rai, U., Majumdar, S.S., 2021. Homeobox transcription factor Meis1 is crucial to Sertoli cell mediated regulation of male fertility. Andrology ;9(2):689-699. doi: 10.1111/andr.12941. Epub 2020 Nov 23. (*Equal Contribution)
4. Sen Sharma, S., Vats, A., Majumdar, S.S., 2019. Regulation of Hippo Pathway components by FSH in testis. Reproductive Biology. 19, 61-66.
5. Sen Sharma, S., Majumdar, S.S., 2017. Transcriptional co-activator YAP regulates cAMP signaling in Sertoli cells. Molecular and Cellular Endocrinol. 450, 64–73.