Profile
Our laboratory at RGCB focuses on chromatin and infectious disease structural biology. We work primarily on nucleosome-interacting and -assembling proteins and certain interesting protein machinery from pathogenic organisms. For this, we make use of an integrative structural biology approach. In addition, structural biology projects are being taken up from time to time on a collaboration basis. As an experimental structural biology research group, our major tools are X-ray crystallography, small-angle X-ray scattering, and cryo-electron microscopy.
Current Focus Areas
Chromatin and Infectious Disease Structural Biology
Selected Publications
Singh, A. K., Datta, A., Chacko, J., Luan, S., Vasudevan, D. (2020). AtFKBP53: a chimeric histone chaperone with functional nucleoplasmin and PPIase domains. Nucleic Acids Research, 48(3): 1531-1550.
Kumari, P., Sundaram, R., Manohar, K., Vasudevan, D., Acharya N. (2021). Interdomain connecting loop and J loop structures determine cross-species compatibility of PCNA. Journal of Biological Chemistry, 297(1): 100911.
Singh, A. K., Saharan, K., Baral, S., Vasudevan, D. (2022). The plant nucleoplasmin AtFKBP43 needs its extended arms for histone interaction. BBA - Gene Regulatory Mechanisms, 1865(7): 194872.
Bobde, R. C., Kumar, A., Vasudevan, D. (2022). Plant-specific HDT family histone deacetylases are nucleoplasmins. The Plant Cell, 34(12): 4760-4777.
Jagdev, M. K., Tompa, D. R., Ling, L. L., Peoples, A. J., Dandapat, J., Mohapatra, C., Lewis, K., Vasudevan, D. (2023).Crystal structure of the N-terminal domain of MtClpC1 in complex with the anti-mycobacterial natural peptide Lassomycin. International Journal of Biological Macromolecules, 253(2): 126771.
Saharan, K., Baral, S., Gandhi, S., Singh, A. K., Ghosh, S., Das, R., Nagaraj, V. A., Vasudevan, D. (2025). Structure-function studies of a nucleoplasmin isoform from Plasmodium falciparum. Journal of Biological Chemistry, 301(4): 108379.