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Nanotechnology (Cancer drug delivery)

S K Sahoo, Ph.D.
Scientist
Institute of Life Sciences
Nalco Square
Bhubaneswar-751023, India
Office: 0091 674 2300137/ 2301476 ext. 221
Fax: 0091 674 2300728
Email: sanjeeb@ils.res.in, sanjeebsahoo2005@gmail.com

 
Publications
Original peer-reviewed articles:
2011

64. Parhi P., Mohanty C. and Sahoo S. K.: Oral delivery and enhanced in vivo pharmacokinetics of rapamycin loaded nanoparticles for pancreatic cancer therapy, Actabiomateriala, 7(10):3656-69, 2011 Impact Factor-4.82 (Press)

63. Behera T., Swain P., Sahoo S. K., Mohapatra D. and Das B.K.: “Immunostimulatory effect of Curcumin in fish, Labio rohita, Indian J of Natural Products and Resources, 2(2), 184-188, 2011. 

62. Parveen S., Misra R. and Sahoo S. K.: ‘Nanoparticles: A Boon to Drug Delivery, Therapeutics, Diagnostics and Imaging’ ‘Nanomedicine: Nanotechnology, Biology, and Medicine’ Nanomedicine USA. Impact Factor-4.88. (Press)

61. Mitra M., Misra R., Sarkar S., Krishnakumar S. and Sahoo S. K.: EpCAM Targeted delivery of drug loaded nano conjugate in retinoblastoma. Molecular Vision. Impact Factor-2.6. (Press)

60. Devilakshmi S., Palanivelu S., Krishnakumar S., Sahoo S. K. and Verma R. S.: Monoclonal antibody for specific targeting of Ep-CAM in various carcinomas, Hybridoma (Press)

59. Parveen S. and Sahoo S. K.: Long circulating chitosan/PEG blended PLGA nanoparticle for tumor drug delivery, Europian J of Pharmacology Impact Factor-2.73 (Press)

58. Acharya S. and Sahoo S. K.: “Sustained targeting of BCR-ABL + leukemia cells by synergistic action of dual drug loaded nanoparticles: An implication for leukemia therapy” Biomaterial, 32(24):5643-62, 2011, Impact Factor-7.88

57. Misra R. and Sahoo S. K.: “Simultaneous modulation of nuclear efflux and drug resistance by curcumin in dual drug loaded nanoparticles enhances the anticancer efficacy of doxorubicin in K562 cells” Molecular Pharmaceutics, 8(3):852-66, 2011, Impact Factor-5.4.

56. Arya G., Vandana M., Acharaya S. and Sahoo S. K.: “Enhanced Antiproliferative Activity of Herceptin (HER 2) - conjugated Gemcitabine loaded chitosan nanoparticle in pancreatic cancer therapy” Nanomedicine USA, Impact Factor-4.88 (Press)

  55. Singh A., Dilnawaz F. and Sahoo S. K.: Composite polymeric magnetic nanoparticles for targeted and controlled co-delivery of hydrophobic and hydrophilic drugs in cancer therapy. Submitted to ACS Applied Material and Interface, 3(3):842-56, 2011, Impact Factor-2.9.  Citation: 2

 54.  Behera T., Swain P. and Sahoo S. K.: Antigen in chitosan coated liposomes enhances immune responses through parenteral immunization. International Immunopharmacology. 11(8):907-14, 2011, Impact Factor-2.4

53. Mitra M., Dilnawaz F., Misra R., Sarkar S., Krishnakumar S. and Sahoo S. K.: Toxicogenomics of nanoparticulate delivery of etoposide: Potential impact on nanotechnology in retinoblastoma therapy. Cancer Nano (Press)

52. Acharya S. and Sahoo S. K.: PLGA nanoparticles containing various anticancer agents and tumor delivery by EPR effect, Advanced Drug Delivery Reviews, 63, 170-183, 2011, Impact Factor-13.57. Citation: 5

51. Das M., Dilnawaz F. and Sahoo S. K.: Targeted nutlin-3a loaded nanoparticles inhibiting p53-MDM2 interaction: Novel strategy for breast cancer therapy.  Nanomedicine (Lond). (3):489-507, 2011, Impact Factor- 6.2

50.  Das M. and Sahoo S. K.: Epithelial cell adhesion molecule targeted nutlin-3a loaded immunonanoparticles for cancer therapy. Acta Biomater. (1):355-69. 2011,  Impact Factor-4.82 Citation: 4

49.  Mohanty C., Das M., Kanwar J. R and Sahoo S. K: Receptor mediated tumor targeting: An emerging approach for cancer therapy, Curr Drug Deliv. ;8(1):45-58. 2011, Impact Factor-2.6. Citation: 4

48.  Parveen S. and Sahoo S. K.: “Evaluation of Cytotoxicity and Mechanism of Apoptosis of Doxorubicin using Folate Decorated Chitosan Nanoparticles for Targeted Delivery to Retinoblastoma” Cancer Nano (1) 47-62, 2011

  2010

47. Behera A. L., Patil S.V. and Sahoo S. K.: Nanosizing of Drugs-APromising Approach for Drug Delivery: A Review” International Journal of Pharmacology and Technology, 2(1), 45-56, 2010

46. Vandana M. and Sahoo S. K.: “Long circulation and cytotoxicity of PEGylated gemcitabine and its potential for the treatment of pancreatic cancer.”  Biomaterials, 31, 9340-9356, 2010. Impact Factor-7.88 Citation: 6

45. Misra R., Acharya S. and Sahoo S. K.: Cancer Nanotechnology: Application of Nanotechnology in cancer therapy, diagnosis and imaging. Drug Discovery Today.15,19-20, 842-850, 2010. Impact Factor-6.4 Citation: 5

44.  Mohanty C. and Sahoo S. K : The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation.. Biomaterials, 31(25), 6597-611, 2010 Impact Factor-7.36 Citation: 8

43. Singh A., Misra R., Mohanty C. and Sahoo S. K.: Applications of Nanotechnology in Vaccine Delivery” “International Journal of Green nanotechnology: Biomedicine, 2:B25-B45, 2010 , Citation:1

42. Mohanty A. K, Dilnawaz F. and Sahoo S. K: Etoposide-loaded biodegradable amphiphilic methoxy (poly ethylene glycol) and poly (epsilon caprolactone) copolymeric micelles as drug delivery vehicle for cancer therapy. Drug Delivery, 17(5), 1-13, 2010 Impact Factor-2.6 Citation: 1

41. Parveen S., Mitra M., Krishnakumar S. and Sahoo S.K: Enhanced Antiproliferative Activity of Carboplatin loaded Chitosan Nanoparticles in Retinoblastoma Cell Line, Acta Biomaterialia, 6, 3120-3131, 2010, Impact Factor-4.82, Citation: 6

40. Dilnawaz F., Singh A., Mohanty C. and Sahoo S. K: Dual drug loaded superparamagnetic iron oxide nanoparticles for targeted cancer therapy. Biomaterials, 31, 3694-3706, 2010, Impact Factor-7.88, Citation: 20

39. Mohanty C., Acharya S., Mohanty A.K, Dilnawaz F., and Sahoo S.K Curcumin encapsulated MePEG/ PCL block copolymeric micelles: A novel controlled delivery vehicle for cancer therapy. Nanomedicine, 5(3), 433-449, 2010, Impact Factor-6.2, Citation: 11

38. Misra R. and Sahoo S.K: Intracellular trafficking of nuclear localization signal conjugated nanoparticles for cancer therapy. Submitted to European J of Pharmaceutical Sciences, 39, 152-163, 2010, Impact Factor-3.29, Citation:20

37.  Behera T., Nanda P. K., Mohanty C., Mohapatra D., Swain P., Das B. K., Routray P., Mishra B. K. and Sahoo S. K.. Parenteral immunization of fish, Labeo rohita with Poly D, L-lactide-co-glycolic acid (PLGA) encapsulated antigen microparticles promotes innate and adaptive immune responses. Fish and Shellfish Immunology, 28, 320-325, 2010, Impact Factor-3.04

36. Mohanty C., Acharya S. and Sahoo S. K.: Micelle: The Multifunctional Nanocarrier for Colloidal Drug Delivery in "Colloids in Drug Delivery" (Edited by Prof. Monzer Fanun ) published by Taylor and Francis/CRC Press, 157-176, 2010.

35. Dilnawaz F., Acharya S., Misra R., Singh A. and Sahoo S. K.: Nanotechnology and Drug delivery in “Bionanoscience, Nanorobotics, and Nanomedicine” (Edited by Prof. Klaus Sattler) published by Taylor & Francis, 27-19, 2010

    2009

34. Mohanty C., Arya G., Verma R. S. and Sahoo S. K, Nanobiotechnology: Application of Nanotechnology in Therapeutics and Diagnosis, International Journal of Green Nanotechnology: Biomedicine, 1: B24-B38, 2009, Citation:1

33.  Vandana M. and Sahoo S. K: Optimization of physicochemical parameters influencing the fabrication of protein-loaded chitosan nanoparticles, 4(7), 373-785, 2009. Citation: 4, Impact Factor:6.2, Citation: 5

32. Acharya S., Dilnawaz F. and Sahoo S. K : Targeted EGFR-nanoparticle bioconjugates for breast cancer therapy, Biomaterials, 1-14, 2009. Impact Factor:7.88, Citation: 34

31. Misra R., Acharya S., Dilnawaz F. and Sahoo S. K : Sustained antibacterial activity of Doxycycline loaded poly (D, L-lactide-co-glycolide) and poly epsilon caprolactone nanoparticles. Nanomedicine, 4(5), 519-530, 2009. Impact Factor:6.2, Citation:15

30.  Das M. Mohanty C. and Sahoo S.K, Ligand-based targeted therapy for cancer tissue, Export Opinion in Drug Delivery, 6, 285-304, 2009. Impact Factor:3.34, Citation:19

29. Baratchi S., Kaur R. K., Khoshmanesh, Vasu P., Ashok C., Hittu M., Parratt A., Krishnakumar S., Sun X., Sahoo S. K and Kanwar J. R., Promises of Nanotechnology for Drug Delivery to Brain in Neurodegenerative Diseases, Current Nanosciences, 5, 15-25, 2009. Impact Factor:1.47, Citation:17

  2008

  28.  Dilnawaz F. and Sahoo S. K, Nanotechnology and its Impact on Aquaculture in Applied Bioinformatics, Statistics and Economics in Fisheries Research (Eds. A.K Roy & Niranjan Sarangi), New India Publishing Agency, New Delhi, 247-259, 2008

  27.  Reddy M. K.,  Vasir J. K., Sahoo S. K, Jain T. K., Yallapu M. M., Labhasetwar V.  Inhibition of Apoptosis Through Localized Delivery of Rapamycin-Loaded Nanoparticles Prevented Neointimal Hyperplasia and Reendothelialized Injured Artery, Circulation Cardiovascular Intervention, 1, 209-216, 2008. Impact Factor: 2.8, Citation:8

  26.  Horning J. L., Sahoo S. K., Vijayaraghavalu S., Dimitrijevic S. , Vasir JK, TK Jain , Panda  A. K, Labhasetwar V.: 3-D Tumor Model for In Vitro Evaluation of Anticancer Drugs. Mol Pharm. 2008. Impact Factor:5.4, Citation:42

  25. Potala S., Sahoo S. K, Verma R.: Targeted therapy of cancer using diphtheria toxin-  derived immunotoxins. Drug Discov Today. 13(17-18): 807-15, 2008. Impact Factor:6.4, Citation:20

  24.  Parveen S.  and Sahoo S. K, Polymeric Nanoparticles for Cancer Therapy. Journal of Drug Targeting, 16(2):108-23, 2008. Impact Factor:2.49, Citation:42

  23. Sahoo S. K, Dilnawaz F and Krishnakumar K.: Nanotechnology in    Ocular Drug Delivery: Drug Discovery Today, 13(3-4) 144-151, 2008. Impact Factor:6.4, Citation:62

 2007

  22.  Sahoo S. K., Parveen S. And Panda J. J., The present and future of nanotechnology in Human Health Care. Journal of Nanomedicine: nanotechnology, Biology and Medicine, 3(1):20-31, 2007. Impact Factor: 4.88, Citation:73

  21.  Sahoo S.K, Jain T., Reddy M. K., Labhasetwar V.: Nano-sized Carriers for Drug Delivery, in  “Nanobiotechnology”, (Eds. Oded Shiseyov and  Elan Levy), Humana Press, Totowa, NJ, 329-348, 2007

   20. Sahoo S. K and Labhasetwar V.; Biodegradable PLGA nanoparticles for anticancer therapy in “Nanotechnology for Cancer Therapeutics” (Ed. Amiji M). CRC Press, 243-250, 2007.

 2006

  19. Parveen S., Krishnakumar K. and Sahoo S. K., New Era in Health Care: Tissue Engineering. Journal of Stem Cells & Regenerative Medicine, (Invited review for the inaugural issue), 1(1), 2006.

  18.  Parveen S., Sahoo S. K.  , Nanomedicine: Clinical applications of Polyethylene Glycol Conjugated Proteins and Drugs, Clinical Pharmakokinetics, 45(10): 965-88, 2006. Impact Factor:4.51, Citation:30

 2005

  17.  Sahoo S. K., and Labhasetwar V.; Nanoparticle Interface: An Important determinant in nanoparticle- mediated drug/gene delivery. In “Nanoparticle Technology for drug delivery” (Ed. Gupta and Kompella), Taylor & Francis Group, New York, 139-160, 2005.

  16.  Sahoo S. K., Applications of Nanomedicine. Asia Pacific Biotech News, 9(20), 48-50, 2005, Citation:2

  15. Sahoo S. K., and Labhasetwar V.; Enhanced antiproliferaive activity of Transferrin conjugated paclitaxel nanoparticles is mediated via sustained intracellular drug retention. Molecular Pharmaceutics, 2(5), 373-383, 2005. (Listed on NCI web site under NCI Alliance for Nanotechnology in Cancer). Impact Factor 5.4, Citation:90

  14.    Tapan K. Jain, Morales M.A., Sahoo S K., D. L. Leslie-Pelecky and Labhasetwa V; Iron Oxide Nanoparticles for Sustained Delivery of Anticancer Agents.. Mol. Pharm,  2(3),194-205, 2005, (Listed on NCI web site under NCI Alliance for       Nanotechnology in Cancer). Impact Factor 5.4, Citation:253 

  13.  Sahoo S. K., Panda A. K and Labhasetwar V.; Characterization of porous PLGA/PLA microparticles as a scaffold for three dimensional growth of breast cancer cells Biomacromolecules, 6(2), 1132-39, 2005. Impact Factor 5.32, Citation:47

2004

12.   Sahoo S. K., Ma W. and Labhasetwar V.; Efficacy of a transferrin-conjugated paclitaxel loaded nanoparticles in a murine model of prostate cancer.
Int. J. of Cancer. 112, 335-340, 2004. (Listed on NCI web site under NCI Alliance for Nanotechnology in Cancer).  Impact Factor 4.92, Citation:75

 2003

  11.  Sahoo S. K., and Labhasetwar V.; Nanotech approaches in drug delivery and imaging. Drug Discovery Today. 8 (24), 1112-1120, 2003. (Invited Review, Listed as top-three most down loaded article by Drug Discovery during Sept 2003 to Sept 2004) Impact Factor 6.4, Citation:259

  10. Sawa T., Sahoo S. K.  and Maeda H.; Water-soluble polymer therapeutics with a special    emphasis on cancer chemotherapy, Arshady R, editor, in: Polymeric Biomaterials, The PBM Series, Vol 1: Introduction to Polymeric Biomaterials, Citus Books, London 2003. 233-61.

   9.    Panayam J., Dhali M. P., Sahoo S. K, Ma W., Chakravarthi S., Amidon A. G., Levy R. J. and Labhasetwar V.; Polymer degradation and in vitro release of a model protein from poly (D,L-lactide-co-glycolide) nano- and microparticles. J. of Control. Release. 92, 173-187, 2003. (Most downloaded article April 2003-March 2004 in Pharmaceitical Sciences). Impact Factor 7.16, Citation:123

   8.  Panyam J., Sahoo S. K, Prabha S., Labhasetwar V.; Fluorescence and Electron microscopy probes for poly (D,L-lactide-co-glycolide) Nanoparticles.
Int. J. Pharm, 262(1-2):1-11, 2003. (Most downloaded article April 2003-March 2004 Pharmaceitical Sciences).  Impact Factor 3.6, Citation:114

   7.   Fang J., Sawa T., Akaike T., Akuta T., Sahoo S. K, Khaled G., Hamada A., and Maeda H.; In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor ; Cancer Research, 63(13):3567-74, 2003. Impact Factor 8.2, Citation:121

   6. Bharali D. J., Sahoo S. K., Majumudar S. and Maitra A. N.; Cross-linked polyvinylpyrrolidone nanoparticles: a potential carrier for hydrophilic drugs; J. Colloid and Interface Sci., 258(2),415-423, 2003. Impact Factor 3.06, Citation:33

 

 2002

   5.  Sahoo S. K, Panayam J., Prabha S and Labhasetwar V.; Residual polyvinyl alcohol associated with poly (D, L-lactide-co-glycolide) nanoparticles affects their physical and cellular uptake properties J. Control. Release. Vol. 82,105-114, 2002. Impact Factor 7.16, Citation:258

   4.  Sahoo S. K., Sawa T., Fang J., Tanaka S., Akaike T. and Maeda H.; PEGylated Zinc protophorphyrin: a water-soluble hemeoxygenase inhibitor with tumor targeting capacity. Bioconjugate Chemistry, 13 (5), 1031-1038, 2002. Impact Factor 5.0, Citation:62

   3.  Panyam J., Zhou W. Z., Prabha S., Sahoo S. K.  and Labhasetwar V.; Rapid endo-lysomal escape of poly (D, L-lactide-co-glycolide) nanoparticles: implication for drug and gene delivery. The FASEB Journal, Vol. 16, 1217-1226, 2002. Impact Factor 6.7, Citation:345

  2000

   2.  Gaur U., Sahoo S. K., De T. K., Ghosh P.C, Maitra A.N.  and Ghosh P. K.; Bio-distribution of fluoresceinated dextran using novel nanoparticles evading reticuloendothelial system, Int. J. Pharm., 202, 1-10, 2000. Impact Factor 3.6, Citation:113

  1998

   1.  Sahoo S. K., De T. K., Ghosh P. K.  and Maitra A.N.; pH & thermo-sensitive hydrogel nanoparticles; J. Colloid and Interface Sci., 206, 361-368, 1998. Impact Factor 3.06, Citation:44

 

PATENTS & PENDING APPLICATIONS:

  1. Maitra AN, Ghosh PK, De TK and Sahoo SK.  Process for the preparation of highly monodispersed polymeric hydrophilic nanoparticles. U.S patent No. 5,874,111, Japan patent No 330406/98, European patent No. 973031271 Indian patent Application no.  2350/DEL/96 dated 20 Dec, 1996.
  2. Maitra AN, Ghosh PK, Sahoo SK and Dabur Research Foundation, Sahibabad, Ghaziabad-201010, India. Formulation of paclitaxel, its derivatives or its analogs entrapped into Nanoparticles of polymeric micelles. U. S.-patent No 6, 322817 B1.
  3. Maitra AN, Ghosh PK, Sahoo SK and Dabur Research Foundation, Sahibabad, Ghaziabad-201010, India. A Process for the preparation of pharmaceutical formulation of paclitaxel entrapped in to polymeric micelles nanoparticles for the treatment of cancer Applied for Indian patent No 263/DEL/99 dated 17Feb, 1999.
  4. Labhasetwar V, Sahoo SK and Reddy MK: Sustained release nanoparticle composition and methords for using the same. University of Nebraska Medical Center, Omaha, NE, USA. US patent no- US 7,727, 554 B2
  5. Labhasetwar V, Sahoo SK: Transferrin conjugated nanoparticles for increasing efficacy of a therapeutic agent. University of Nebraska Medical Center, Omaha, NE, USA. US patent Application No-11/124, 934, filled on 9th May, 2005.
  6. Sahoo S. K, Dilnawaz F and Singh A: A methord for preparing a water dispersible magnetic nanoparticle formulation and use the same. Indian Patent Application No 779/KOL/2009 of 21/5/2009 and International PCT Application No.PCT/IN09/000639 of 12/11/2009.
  7. Sahoo SK and Mohanty C: A novel water soluble curcumin loaded nanoparticulate system for cancer therapy. Indian Patent Application No 164/KOL/2010 of 22/2/2010, International PCT Application No.PCT/IN2010/000618 of 26/10/2010.
  8. Sahoo SK and Mohanty C: A process for preparing curcumin encapsulated chitosan-Alginate sponge useful for wound healing. Indian Patent Application No 1189/KOL/2010 of 27/10/2010, International PCT Application No. PCT/IN2010/000813 Dt.14.1.2011
  9. Sahoo SK and Vandana M: A water soluble PEGylated pemetraxed and a process for the same. Indian Patent Application No 1405/KOL/2010 of 18/12/2010
  10. Sahoo SK, Pardhi P and Mohanty C: Drug delivery formulation of rapamycin in the form of polymeric nanoparticles. Indian Patent Application No-38/KOL/2011
  11.  Sahoo SK and Vandana M: A water soluble polymeric drug formulation and a process for the same. Indian Patent Application No 77/KOL/2011 of 20/1/2011

 

 

 

 

 

 
 

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