INSTITUTE OF LIFE SCIENCES

An autonomous institute of Department of Biotechnology, Govt. of India
Bhubaneswar, India

 

Home
 
Profile Research Publications Group Grants
         

 

Nanotechnology (Cancer drug delivery)

 
S K Sahoo, Ph.D.
 Scientist
Institute of Life Sciences
Nalco Square
Bhubaneswar-751023, India
 Office: 0091 674 2300137/ 2301476 ext. 221
Fax: 0091 674 2300728
Email: sanjeeb@ils.res.in, sanjeebsahoo2005@gmail.com
 
   
  • Nanoscience and Nanotechnology in Nanomedicine
  • Nanotechnology to Cancer Therapy
  • New Biomaterials for use in Tissue Engineering
  • Formulation design, development and evaluation of biodegradable nanoparticle based drug and gene delivery systems.Improvement in drug delivery formulations using macromolecular conjugation of anticancer drugs and proteins. Targeting of drug loaded particulate system for enhanced therapeutic action to specific sites.

Research Area
The Mission of the Laboratory for Nanomedicine at the Institute of Life Sciences, Bhubaneswar is to create a multidisciplinary research environment that will provide expertise and foster collaborations for the design, development and translation into clinic of nanomaterials for therapeutic and diagnostic purposes. Our laboratory focuses its research efforts on finding ways to expand the utility of biodegradable nanoparticulate based advanced drug delivery system for more effectively treat and prevent different diseases. These are the few areas

Targeted Delivery of Nanoparticulate Drug Delivery Systems for Cancer Therapy
Nanotechnology is a multidisciplinary scientific undertaking, involves creation and utilization of materials, devices, or systems on the nanometer scale. The technology is expected to create innovations and play a critical role in various biomedical applications, not only in drug delivery, but also in molecular imaging, biomarkers, and biosensors. Target specific drug therapy and methods for early diagnosis of pathologies are the priority research areas where nanotechnology would play a vital role. Our laboratory is studying the methods which will allow targeting of biodegradable nanoparticles to specific sites or tissues of interest. These nanoparticles can contain a wide variety of drugs to be delivered, and the targeting moiety in the drug delivery system be chemically coupled with the nanoparticle. Our current research projects include targeted drug delivery to the vascular system and to different cancer cells (breast and prostate cancer cells).

Macromolecular conjugation of peptides and proteins improving therapeutic index
The use of proteins and peptides as therapeutic agents is hampered by their rapid elimination from the circulation through renal filtration, enzymatic degradation, and uptake by reticuloendothelial system and accumulation in non-targeted organs and tissues. Macromolecular conjugation in particular PEGylation protein and drugs has been widely used now days to improve the therapeutic index of drugs. Most solid tumors possess unique pathophysiological characteristics that are not observed in normal tissues or organs, such as extensive angiogenesis and hence hypervasculature, defective vascular architecture, impaired lymphatic drainage / recovery system, and greatly increased production of a number of permeability mediators. The phenomenon now known as the enhanced permeability and retention (EPR) effect for lipid and macromolecular agents has been observed to be universal in solid tumors. I want to explore both macromolecular conjugation and polymer particulate delivery system for improved bioavailablity and efficacy of anticancer drugs and therapeutics.

Biomaterial for Tissue Engineering
Advanced interdisciplinary scientific field of tissue engineering has been developed to meet increasing demand for safe, functional and easy available substitutes of irreversibly damaged tissues and organs. First biomaterials were constructed as "two-dimensional" (allowing cell adhesion only on their surface), and durable (non-biodegradable). In contrast, biomaterials of new generation are characterized by so-called three dimensional porous or scaffold-like architecture promoting attachment, growth and differentiation of cells inside the material, accompanied by its gradual removal and replacement with regenerated fully functional tissue.

Tissue engineering has evolved to address the increasing need in tissues and organs for transplantation. The neo-tissue is constructed by seeding functional cells, originated from either donors or differentiated stem cells within three-dimensional (3D) polymeric scaffolds, which provide the biomechanical support until the cells develop into a functioning tissue. Currently I am exploring the possibilities of design, formulation and evaluation of PLGA/PLA based porous particulate structure for the growth of animal cells. The particle formulation technology provides an excellent method for preparation of biocompatible polymer scaffold by blending with both natural and artificial polymers. These scaffold can further be used either for tissue generation, model for in vitro evaluation of drugs or combination of polymer scaffold and nanoparticles based drug delivery can be used for regenerative tissue engineering.

 

Distinctions/ Fellowships/ Awards and Achievements

  •  Awarded International Fellowship for Young Biomedical Scientists from ICMR for four months in 2008 to work at Creighton University, Omaha, Nebraska, USA
     
  •   Awarded Postdoctoral fellowship from the American Heart Association (AHA), United States of America (2002-
           2004).
     
  • Awarded Japanese Society for Promotion of Science (JSPS) postdoctoral fellowship from the Government of Japan (1999-2001).
     
  • U.S. Patent No-5, 874,111 “Process for the preparation of highly monodispersed hydrophilic polymeric nanoparticles”.
     
  • U. S. Patent No-6, 365, 91 “ Formulation of Paclitaxel, its derivatives or its analogs entrapped in to nanoparticles of polymeric micelles, process for preparing same and the use there of. The patented formulation is under clinical trial by Dabur India Ltd, New Delhi, India.
     
  • Awarded travel grant from the School of Pharmacy, University of London to attend the 3rd International symposium on Polymer Therapeutics from Laboratory to Clinical Practice, January 7th –9th 1998, School of Pharmacy, University of London, UK.
     
  • Secured (84.07 percentile) All India Graduate Aptitude Test in Engineering  (GATE) in 1996
     
  • Awarded Junior Research Fellowship (JRF, 1996-98) University Grant Commission, Government of India.
     
  • Awarded Senior Research Fellowship (SRF, 1998-1999), University Grant Commission, Government of India.
     
  • Funding: Postdoctoral fellowship from American Heart Association (Heartland affiliated) in the project “Micellar nanosystem for localized arterial delivery of rapamycin to inhibit Restenosis” (July 2002-June 2004, $ 86,879).                

Areas of research interest 

  • Broad area of Nanobiotechnology.
  • Formulation design, development and evaluation of biodegradable nanoparticle based drug and gene delivery systems for treatment of cancer.
  •  Improvement in drug delivery formulations using macromolecular conjugation of anticancer drugs and proteins. Targeting of drug loaded particulate system for enhanced therapeutic action to specific sites.

 Scientific and Professional Activities 

Organising Conferences and Work Shop

  • Organising secretary, 2nd International Conference on Drug Discovery & Therapy, February 1-4, 2010, Duabi, UAE, www.icddt.com 

  • Organised a workshop on Nanomedicine, February 6th -7th, 2008, Institute of Life Sciences, Bhubaneswar, Orissa, India. 

Organised an International Conferences on Nanomedicine February 22nd -23rd, 2007, Institute of Life Sciences, Bhubaneswar, Orissa, India. 

Journal Reviewer

Journal of Colloid and Interface Science, Biomacromolecules, Journal of Biomedical Nanotechnology, Drug Discovery Today, Export Opinion in Drug Delivery, Asain Journal of Pharmaceutics, Biomedical Materials, Future Nanomedicine, International Journal of Nanomedicine, Journal of Physics Condensed Matter, Nanotechnology, Expert Review of Molecular Diagnostics, Biomaterials, Nanomedicine:Nanotechnology, Biology and Medicine, Current Nanosciences

Professional Affiliation 

  •  American Association of Pharmaceutical Scientists
     
  • Journal of Controlled Release Society
     
  •  American Heart Association

 

Publications

Research Papers Published (in Peer reviewed Journals)

  1. Misra R and Sahoo S.K: Intracellular trafficking of nuclear localization signal conjugated nanoparticles for cancer therapy. Submitted to European J of Pharmaceutical Sciences, (Press) Impact Factor-3.65
  2. Behera T, Nanda P K, Mohanty C, Mohapatra D, Swain P, Das B K, Routray P, Mishra B K and Sahoo S K. Parenteral immunization of fish, Labeo rohita with Poly D, L-lactide-co-glycolic acid (PLGA) encapsulated antigen microparticles promotes innate and adaptive immune responses. Fish and Shellfish Immunology, (Press), (Impact Factor-3.16)
  3. Mohanty C, Acharya S and Sahoo SK: Micelle: The Multifunctional Nanocarrier for Colloidal Drug Delivery in "Colloids in Drug Delivery" (Edited by Prof. Monzer Fanun ) published by Taylor and Francis/CRC Press, 2009 (Press)
  4. Dilnawaz F, Acharya S, Misra R, Singh A and Sahoo SK: Nanotechnology and Drug delivery in “Bionanoscience, Nanorobotics, and Nanomedicine” (Edited by Prof. Klaus Sattler) published by Taylor & Francis, 2009 (Press)
  5. Mohanty C, Arya G, Verma RS and Sahoo S.K, Nanobiotechnology: Application of Nanotechnology in Therapeutics and Diagnosis, International Journal of Green Nanotechnology: Biomedicine, 1: B24-B38, 2009
  6. Vandana M and Sahoo S. K: Optimization of parameters influencing the fabrication of protein loaded chitosan nanoparticles. Nanomedicine, 4(7), 373-785, 2009. (Impact Factor: 6.2)
  7. Acharya S, Dilnawaz F and Sahoo S.K : Targeted EGFR-nanoparticle bioconjugates for breast cancer therapy, submitted to Biomaterials, 1-14, 2009. (Impact Factor: 6.6)
  8. Misra R, Acharya S, Dilnawaz F and Sahoo S. K : Sustained antibacterial activity of Doxycycline loaded poly (D, L-lactide-co-glycolide) and poly epsilon caprolactone nanoparticles. Nanomedicine, 4(5), 519-530, 2009. (Impact Factor: 6.2)
  9. Das M. Mohanty C and Sahoo S.K, Ligand-based targeted therapy for cancer tissue, Export Opinion in Drug Delivery, 6, 285-304, 2009. (Impact Factor: 2.8)
  10. Baratchi S, Kaur R K, Khoshmanesh, Vasu P, Ashok C, Hittu M, Parratt A, Krishnakumar S, Sun X, Sahoo S.K and Kanwar J R, Promises of Nanotechnology for Drug Delivery to Brain in Neurodegenerative Diseases, Current Nanosciences, 5, 15-25, 2009. (Impact Factor: 2.8)
  11. Dilnawaz F and Sahoo S.K, Nanotechnology and its Impact on Aquaculture in Applied Bioinformatics, Statistics and Economics in Fisheries Research (Eds. A.K Roy & Niranjan Sarangi), New India Publishing Agency, New Delhi, 247-259, 2008
  12. Reddy MK,  Vasir JK, Sahoo S.K, Jain TK, Yallapu MM, Labhasetwar V  Inhibition of Apoptosis Through Localized Delivery of Rapamycin-Loaded Nanoparticles Prevented Neointimal Hyperplasia and Reendothelialized Injured Artery, Circulation Cardiovascular Intervention, 1, 209-216, 2008. (Impact Factor: 2.8)
  13. Horning JL, Sahoo S. K., Vijayaraghavalu S S Dimitrijevic , Vasir JK, TK Jain , Panda  AK, Labhasetwar V: 3-D Tumor Model for In Vitro Evaluation of Anticancer Drugs. Mol Pharm. 2008, (Impact Factor: 3.5)
  14. Potala S, Sahoo S. K, Verma R: Targeted therapy of cancer using diphtheria toxin-derived immunotoxins. Drug Discov Today. 13(17-18): 807-15, 2008. (Impact Factor: 7.7)
  15. Parveen S.  and Sahoo S. K, Polymeric Nanoparticles for Cancer Therapy. Journal of Drug Targeting, 16(2):108-23, 2008. (Impact Factor: 2.03)
  16. Sahoo S. K, Dilnawaz F and Krishnakumar K. : Nanotechnology in    Ocular Drug Delivery: Drug Discovery Today, 13(3-4) 144-151, 2008. (Impact Factor: 7.7)
  17. Sahoo S. K., Parveen S.  and Panda J. J., The present and future of nanotechnology in Human Health Care. Journal of Nanomedicine: Nanotechnology, Biology and Medicine, 3(1):20-31,2007
  18. Sahoo S. K and Labhasetwar V.; Biodegradable PLGA nanoparticles for anticancer therapy in “Nanotechnology for Cancer Therapeutics” (Ed. Amiji M). CRC Press, 243-250, 2007.
  19. Sahoo S.K, Jain T, Reddy MK, Labhasetwar V: Nano-sized Carriers for Drug Delivery, in  “Nanobiotechnology”, (Eds. Oded Shiseyov and  Elan Levy), Humana Press, Totowa, NJ, 329-348, 2007
  20. Parveen S, Krishnakumar K. and Sahoo S. K., New Era in Health Care: Tissue Engineering. Journal of Stem Cells & Regenerative Medicine, (Invited review for the inaugural issue), 1(1), 2006
  21. Parveen S., Sahoo S. K.  , Nanomedicine: Clinical applications of Polyethylene Glycol Conjugated Proteins and Drugs, Clinical Pharmakokinetics, 45(10): 965-88, 2006. (Impact Factor: 4.1)
  22. Sahoo S. K., and Labhasetwar V.; Nanoparticle Interface: An Important determinant in nanoparticle- mediated drug/gene delivery. In “Nanoparticle Technology for drug delivery” (Ed. Gupta and Kompella), Taylor & Francis Group, New York, 139-160, 2005.
  23. Sahoo S. K., Applications of Nanomedicine. Asia Pacific Biotech News, 9(20), 48-50, 2005
  24. Sahoo S. K., and Labhasetwar V.; Enhanced antiproliferaive activity of Transferrin conjugated paclitaxel nanoparticles is mediated via sustained intracellular drug retention. Molecular Pharmaceutics, 2(5), 373-383, 2005. (Listed on NCI web site under NCI Alliance for Nanotechnology in Cancer). (Impact Factor 3.5)
  25. Tapan K. Jain, Morales M.A., Sahoo S K., D. L. Leslie-Pelecky and Labhasetwa V; Novel Formulation of Iron-oxide Nanoparticles for Drug Delivery. Mol. Pharm, 2(3), 194-205. (Listed on NCI web site under NCI Alliance for Nanotechnology in Cancer).  (Impact Factor 3.5)
  26. Sahoo S. K., Panda A. K and Labhasetwar V.; Characterization of porous PLGA/PLA microparticles as a scaffold for three dimensional growth of breast cancer cells Biomacromolecules, 6(2), 1132-39, 2005. (Impact Factor 4.1)
  27. Sahoo S. K., Ma W. and Labhasetwar V.; Efficacy of a transferrin-conjugated paclitaxel loaded nanoparticles in a murine model of prostate cancer.
    Int. J. of Cancer. 112, 335-340, 2004. (Listed on NCI web site under NCI Alliance for Nanotechnology in Cancer).  (Impact Factor 4.5)
  28. Sahoo S. K., and Labhasetwar V.; Nanotech approaches in drug delivery and imaging. Drug Discovery Today. 8 (24), 1112-1120, 2003. (Invited Review, Listed as top-three most down loaded article by Drug Discovery during Sept 2003 to Sept 2004) (Impact Factor 7.7)
  29. Sawa T., Sahoo S. K.  and Maeda H.; Water-soluble polymer therapeutics with a special    emphasis on cancer chemotherapy, Arshady R, editor, in: Polymeric Biomaterials, The PBM Series, Vol 1: Introduction to Polymeric Biomaterials, Citus Books, London 2003; 233-61,
  30. Panayam J., Dhali M. P., Sahoo S. K, Ma W., Chakravarthi S., Amidon A. G., Levy R. J.  and Labhasetwar V.; Polymer degradation and in vitro release of a model protein from poly (D,L-lactide-co-glycolide) nano- and microparticles. J. of Control. Release. 92, 173-187, 2003. (Most downloaded article April 2003-March 2004 in Pharmaceitical Sciences)(Impact Factor 4.7)
  31. Panyam J., Sahoo S. K, Prabha S., Labhasetwar V.; Fluorescence and Electron microscopy probes for poly (D,L-lactide-co-glycolide) Nanoparticles.
    Int. J. Pharm, 262(1-2):1-11, 2003. (Most downloaded article April 2003-March 2004 Pharmaceitical Sciences)  (Impact Factor 2.4)
  32. Fang J., Sawa T., Akaike T., Akuta T., Sahoo S. K, Khaled G., Hamada A., and Maeda H.; In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor ; Cancer Research, 63(13):3567-74, 2003. (Impact Factor 7.6)
  33. Bharali D. J., Sahoo S. K., Majumudar S. and Maitra A. N.; Nanometer size polyvinyl pyrrolidone nanoparticles as drug delivery carriers; J. Colloid and Interface Sci., 258(2),415-423, 2003. (Impact Factor 2.3)
  34. Sahoo S. K, Panayam J., Prabha S and Labhasetwar V.; Residual polyvinyl alcohol associated with poly (D, L-lactide-co-glycolide) nanoparticles affects their physical and cellular uptake properties J. Control. Release. Vol. 82,105-114, 2002. (Impact Factor 4.7)
  35. Sahoo S. K., Sawa T., Fang J., Tanaka S., Akaike T. and Maeda H.; PEGylated Zinc protophorphyrin: a water-soluble hemeoxygenase inhibitor with tumor targeting capacity. Bioconjugate Chemistry, 13 (5), 1031-1038, 2002. (Impact Factor 4.3)
  36. Panyam J., Zhou W. Z., Prabha S., Sahoo S. K.  and Labhasetwar V.; Rapid endo-lysomal escape of poly (D, L-lactide-co-glycolide) nanoparticles: implication for drug and gene delivery. The FASEB Journal, Vol. 16, 1217-1226, 2002. (Impact Factor 7.1)
  37. Gaur U., Sahoo S. K., De T. K., Ghosh P.C, Maitra A.N.  and Ghosh P. K.; Bio-distribution of fluoresceinated dextran using novel nanoparticles evading reticuloendothelial system, Int. J. Pharm., 202, 1-10, 2000. (Impact Factor 2.4)
  38. Sahoo S. K., De T. K., Ghosh P. K.  and Maitra A.N.; pH & thermo-sensitive hydrogel nanoparticles; J. Colloid and Interface Sci., 206, 361-368, 1998. (Impact Factor 2.3)

 National and International Patents 

  1. A. N. Maitra, P. K. Ghosh, T. K .De and S. K. Sahoo.  Process for the preparation of highly monodispersed polymeric hydrophilic nanoparticles. U.S patent No. 5,874,111, Japan patent No 330406/98, European patent No. 973031271 Indian patent Application no.  2350/DEL/96 dated 20 Dec, 1996.
  2. A. N. Maitra, P. K. Ghosh, S. K. Sahoo and Dabur Research Foundation, Sahibabad, Ghaziabad-201010, India. Formulation of paclitaxel, its derivatives or its analogs entrapped into Nanoparticles of polymeric micelles. U. S.-patent No 6, 322817 B1.
  3. A. N. Maitra, P. K. Ghosh, S. K. Sahoo and Dabur Research Foundation, Sahibabad, Ghaziabad-201010, India. A Process for the preparation of pharmaceutical formulation of paclitaxel entrapped in to polymeric micelles nanoparticles for the treatment of cancer Applied for Indian patent No 263/DEL/99 dated 17Feb, 1999.
  4. A. N. Maitra, P. K. Ghosh, S. K. Sahoo and Dabur Research Foundation. Sahibabad, Ghaziabad-201010, India. A pharmaceutical composition of paclitaxel for the treatment of pathological conditions arising out of excessive proliferation of cells Applied for Indian and US Patents Submitted.
  5. V. Labhasetwar, S. K. Sahoo and M. K. Reddy: Sustained release nanoparticle composition and methords for using the same. University of Nebraska Medical Center, Omaha, NE, USA. US patent Application No-11/018, 456, filled on 21st December, 2004.
  6. V. Labhasetwar, S. K. Sahoo: Transferrin conjugated nanoparticles for increasing efficacy of a therapeutic agent. University of Nebraska Medical Center, Omaha, NE, USA. US patent Application No-11/124, 934, filled on 9th May, 2005.
  7. Sahoo S. K, F Dilnawaz and A Singh: A methord for preparing a water dispersible magnetic nanoparticle formulation and use the same. Indian Patent Application No 779/KOL/2009 of 21/5/2009

 Research Presentation 

1.    A. Singh, F. Dilnawaz and S. K. Sahoo, Transferrin conjugated dual drug loaded polymeric magnetic nanoparticles for breast cancer therapy. 3rd International Symposium on Translational Cancer Research, Cell Signaling and Cancer Therapy, December 18-21, 2009, Bhubaneswar, Orissa, India. 

2.    F. Dilnawaz, A. Singh,C. Mohanty and S. K. Sahoo, Antibody conjugated, combinational drug loaded magnetic nanoparticles for breast cancer therapy. 3rd International Symposium on Translational Cancer Research, Cell Signaling and Cancer Therapy, December 18-21, 2009, Bhubaneswar, Orissa, India. 

3.    M Das and S K. Sahoo, Inhibition of p53-MDM2 interaction by surface functionalized nutlin-3a loaded PLGA nanoparticles- a novel therapeutic strategy for breast cancer. 3rd International Symposium on Translational Cancer Research, Cell Signaling and Cancer Therapy, December 18-21, 2009, Bhubaneswar, Orissa, India. 

4.    R. Misra and S K. Sahoo, nls-conjugated doxorubicin loaded PLGa nanoparticles for breast cancer therapy. 3rd International Symposium on Translational Cancer Research, Cell Signaling and Cancer Therapy, December 18-21, 2009, Bhubaneswar, Orissa, India. 

5.    S. Acharya, F. Dilnawaz and S. K. Sahoo, Targeted epidermal growth factor receptor nanoparticle bioconjugates for breast cancer therapy. 3rd International Symposium on Translational Cancer Research, Cell Signaling and Cancer Therapy, December 18-21, 2009, Bhubaneswar, Orissa, India. 

6.    S. Parveen and S.K Sahoo, Influence of Surface Modification of Poly-l-Lactide-co-Glycolide Nanoparticles with Chitosan and Polyethylene Glycol for Tumor Drug Delivery. 3rd International Symposium on Translational Cancer Research, Cell Signaling and Cancer Therapy, December 18-21, 2009, Bhubaneswar, Orissa, India.

7.    G. Arya, M. Vandana and S. K. Sahoo, Gemcitabine loaded Chitosan TPP nanoparticle in treatment of pancreatic cancer. 3rd International Symposium on Translational Cancer Research, Cell Signaling and Cancer Therapy, December 18-21, 2009, Bhubaneswar, Orissa, India. 

8.    C. Mohanty, S. Acharya, A. K. Mohanty, F. Dilnawaz and S. K. Sahoo, Curcumin encapsulated MePEG/ PCL block copolymeric micelles: A novel controlled delivery vehicle for pancreatic cancer therapy. 3rd International Symposium on Translational Cancer Research, Cell Signaling and Cancer Therapy, December 18-21, 2009, Bhubaneswar, Orissa, India. 

9.    M. Vandana and S. K Sahoo, PEGylated Gemcitabine as a Potential Candidate for the Treatment of Pancreatic Cancer: Synthesis, in vitro and in vivo Studies, 3rd International Symposium on Translational Cancer Research, Cell Signaling and Cancer Therapy, December 18-21, 2009, Bhubaneswar, Orissa, India. 

10.  S Parveen, M Mitra, S. Krishnakumar and S K Sahoo Investigation of the Enhanced Antiproliferative Activity of Carboplatin loaded Biodegradable Chitosan Nanoparticles in Retinoblastoma Cell Line. 36th International Symposium on Controlled Release of Bioactive Materials, July 18-22, 2009, Copenhagan, Netherland.

11.     F Dilnawaz, A K. Mohanty, and S K. Sahoo A sustainable amphiphilc methoxy polyethylene glycol and poly (epsilon caprolactone) copolymeric micelles as drug delivery vhehicle for pancreatic cell lines. 36th International Symposium on Controlled Release of Bioactive Materials, July 18-22, 2009, Copenhagan, Netherland.

12.     S K Sahoo, M Mitra, F Dilnawaz, R Misra and S Krishnakumar Cytotoxicity effect of etoposide loaded Poly (lactide–Co-glycolide) (PLGA) nanoparticles in retinoblastoma cell lines. 36th International Symposium on Controlled Release of Bioactive Materials, July 18-22, 2009, Copenhagan, Netherland. 

13.  M. Vandana, and S.K Sahoo, Optimization of parameters influencing the fabrication of protein loaded chitosan nanoparticles, The International Symposium on Emerging Areas in Biotechnology & Bioengineering, 25th-28th February, 2009, Bombay, India 

14.  S. Acharya, A K. Mohanty, F. Dilnawaz and S.K Sahoo, A sustainable amphiphile methoxy polyethylene glycol and poly (epsilon caprolactone) copolymeric micelles as drug delivery  vehicle for pancreatic cell lines, The International Symposium on Emerging Areas in Biotechnology & Bioengineering, 25th-28th February, 2009, Bombay, India. 

15.  F. Dilnawaz, A K Mohanty and S. K Sahoo, A biodegradable amphiphilic methoxy poly(ethylene glycol) and poly (caprolactone) copolymeric micelles loaded with etoposide as drug delivery vehicles for pancreatic cancers, Indo-US Symposium on Cancer Nanotechnology, 4-6th February, 2009, Delhi, India 

16.  F. Dilnawaz, A. Hata, A. N. Mitra, C. Mohanty, Krishnakumar S, and S. K Sahoo, 3-d growth of retinoblastoma cells in a biodegradable polymeric scaffold International Conference on Medical Materials, Devices and Regenerative Medicine, 23-25 November, 2008 Kathmandu, Nepal  

17.  H Anju, M Moutushy, S.K Sahoo, Krishnakumar S. 3D growth of Retinoblastoma in a Biodegradable Polymer Scaffold. Presented in International Conference on Nano-medicine & Recent Advances in Opthalmic research. September 3-5th, 2008, Sankara Nethralaya, Chennai, India 

18.  M Moutushy, F. Dilnawaz, R Mishra, H Anju, S sharmila, Krishnakumar S and S.K Sahoo. Formulation and characterization of Etoposide loaded PLGA nanoparticles and their cytotoxicity effect on Retinoblastoma cells. Presented in International Conference on Nano-medicine & Recent Advances in Opthalmic research. September 3-5th, 2008, Sankara Nethralaya, Chennai, India 

19.  F Dilnawaz, A. K Mohanthy, and S. K Sahoo. Etoposide loaded Methoxy Poly (ethylene glycol) and Poly (ξ-caprolactone) amphiphilic block copolymeric micelles as a novel drug delivery vehicle for pancreatic cell lines. Presented in International Conference on Nano-medicine & Recent Advances in Opthalmic research. September 3-5th, 2008,  Sankara Nethralaya, Chennai, India 

20.  Kandalam, S. K. Sahoo and S. Krishnakumar, Three-dimensional growth of Retinoblastoma in a Polymer Scaffold. International Conference on Design of Biomaterials, 8-11th December, 2006 , Indian Institute of Technology, Kanpur, India  

21.  S.K. Sahoo, M.K. Reddy, T.K.Jain, M.M. Yallapu, J.K.Vasir and V.Labhasetwar, Localized arterial delivery of rapamycin-loaded nanoparticles inhibits hyperplasi: study in rat carotid model of vascular injury, 4th International Nanomedicine and Drug Delivery Symposium, Octobar8th-10th, 2006, Omaha, Nebraska, USA 

22.  Sahoo S.K, M.K. Reddy, T.K.Jain, M.M. Yallapu, J.K.Vasir and V.Labhasetwar, Non-Stent approach to inhibition of restenosis. Indo-US symposium on Nanotechnology in Advanced Drug Delivery, Octobar4th-6th, 2006, NIPER, Mohali, India  

23.  S. K. Sahoo, A. K. Panda, J. Horning, T. K. Jain and V Labhasetwar. Tissue model for in vitro evaluation of anticancer agents, 33rd Annual Meeting & Exposition of the Controlled Release Society, July 22 - 26, 2006, Vienna, Austria.  

24.  A Ghorpade , K. Rao , P. Sahoo, S. K Sahoo, K. Borgmann, R. Peridsky, V. Labhasetwar: Ritonavir nanoparticles inhibit productive replication of HIV-1ADA in MDM, Poster Presentation at Conference on Retroviruses and Opportunistic Infections, at Denver (Colorado) - February 5-9, 2006 

25.  S. K. Sahoo, and V. Labhasetwar; Enhanced antiproliferative activity of Transferrin conjugated paclitaxel nanoparticles is mediated via sustained intracellular drug retention. Abstract submitted for 1st Indo-Japanese International conferences on Advances in Pharmaceutical Research and Technology, November 26-29, 2005, Mumbai, India 

26.  A Ghorpade, K. Rao , P. Sahoo, S. K Sahoo, K. Borgmann, R. Peridsky, V. Labhasetwar: Ritonavir nanoparticles inhibit productive replication of HIV-1ADA in monocyte-derived macrophages (MDM): 32nd International Symposium on Controlled Release of Bioactive Materials, June 18-22, 2005, Miami, Florida, USA. 

27.  S. K. Sahoo, and V. Labhasetwar; Enhanced antiproliferative activity of Transferrin conjugated paclitaxel nanoparticles is mediated via sustained intracellular drug retention. 32nd International Symposium on Controlled Release of Bioactive Materials, June 18-22, 2005, Miami, Florida, USA. 

28.  S. K. Sahoo, A. K Panda and V. Labhasetwar; Characterization of porous PLGA/PLA microparticles as a scaffold for three dimensional growth of breast cancer cells. Abstract submitted for 32nd International Symposium on Controlled Release of Bioactive Materials, June 18-22, 2005, Miami, Florida, USA. 

29.  S. K. Sahoo, Ma W and V. Labhasetwar; Efficacy of a transferrin-conjugated paclitaxel loaded nanoparticles in a murine model of prostate cancer. Symposium on biomedical applications of magnetic nanostructures. October 8, 2004, University of Nebraska at Lincon, Nebraska, USA. 

30.  S. K. Sahoo, J. Panayam, S. Prabha and V. Labhasetwar; Residual polyvinyl Alcohol associated with poly (D, L-lactide-co-glycolide) nanoparticles affects their physical and cellular uptake properties. Symposium on biomedical applications of magnetic nanostructures. October 8, 2004, University of Nebraska at Lincon, Nebraska, USA. 

31.  S. K. Sahoo, Ma W and V. Labhasetwar; Efficacy of a transferrin-conjugated paclitaxel loaded nanoparticles in a prostate cancer mice model. Proceeding International Symposium on Controlled Release of Bioactive Materials; 2004, Honululu, Hawaii, USA. 

32.  E. Neilson, S. K. Sahoo, V. Labhasetwar. Doxorubicin-loaded Poly Lactide nanoparticles significantly decreases viability of MCF-7 breast cancer cells and cellular uptake may be improved without the use of polyvinyl alcohol as an emulsifier. 29th Annual West Coast Biological Sciences Under Graduate Research Conferences, 2004 Point Loma Nazarene University, San Diego, California, USA,  

33.  J. Panayam, S. Prabha, S. K. Sahoo and V. Labhasetwar; Selective cationization of PLGA nanoparticles in endo-lysosomal compartment results in their cytoplasmic escape. The 34th Annual Midwest Student Biomedical Research Forum, Feb 2003, Omaha, NE 

34.  S. K. Sahoo, J. Panayam, S. Prabha and V. Labhasetwar; Residual Polyvinyl Alcohol Associated with poly (D, L-lactide-co-glycolide) nanoparticles affects their physical and cellular uptake properties. Globalizatiom of Pharmaceutics Education Network, GPEN 2002, November 6-8, University of Michigan, Ann Arbor, USA. 

35.  V. Labhasetwar, J. Panyam, S. Prabha and S. K. Sahoo; Nanoparticles for drug and gene delivery. Proceeding International Symposium on Controlled Release of Bioactive Materials; 2002, Seoul, South Korea.  

36.  J. Panyam, S. Prabha, S. K. Sahoo, and V. Labhasetwar; Selective cationization of PLGA nanoparticles in endo-lysosomal compartment, results in their cytoplasmic Escape. Annual Post-Graduate Student Research Meeting (PGSRM) June 15th –18th, 2002. University of Nebraska Medical Center, Omaha, USA.  

37.  S. K. Sahoo, J. Panayam, S. Prabha and V. Labhasetwar; Residual polyvinyl Alcohol associated with poly (D, L-lactide-co-glycolide) nanoparticles affects their physical and cellular uptake properties. Annual Pharmaceutics Post-Graduate Student Research Meeting (PGSRM), June 15th –18th, 2002. University of Nebraska Medical Center, Omaha, USA,  

38.  S. Chakravarthi, J. Panayam, S. K. Sahoo and V. Labhasetwar; Polymer degradation of PLGA nano and micro particles is particle size independent. Pharmaceutics Graduate Student Research Meeting (PGSRM), June 15th –18th, 2002. University of Nebraska Medical Center, Omaha, USA. 

39.  J. Panyam, S. Prabha, S. K. Sahoo, and V. Labhasetwar; Evidence for rapid escape of nanoparticles from endosomes. 5th International Symposium on Polymer Therapeutics, From Laboratory to Clinical Practice, January 2nd –4th, 2002, Welsh, UK. 

40.  T. Sawa, S. K. Sahoo, J. Fang, T. Tanaka, T. Akaike and H. Maeda; PEGylated Zinc protophorphyrin: a water-soluble heme oxygenase inhibitor with potent anti-tumor activity. 8th Annual meeting of the Oxygen Society, November 15th - 19th, 2001, Research Triangle Park, North Carolina, USA.  

41.  S. K. Sahoo, T. Sawa and H. Maeda; “Preparation and characterization of cross-linked polymeric micelles of N-isopropyl-acrylamide and vinylpyrrolidone for the Delivery of Anticancer Drug Paclitaxel” Japanese Biochemical Society, October 11th-14th, 2000, Yokohama, Japan 

42.  S. K. Sahoo, P. K. Ghosh, T. K. De, U. Gaur, P.C. Ghosh and A. N. Maitra; (1998) Long circulating hydrophilic nanoparticles. 3rd International symposium on polymeric therapeutics from laboratory to clinical practice, January 7th- 10th, 1998, University of London, U.K. 

43.  N. Maitra, S. K. Sahoo, U. Gaur, P. C. Ghosh and P. K. Ghosh; RES evading long circulating hydrophilic nanoparticles. Proceeding International Symposium on Controlled Release of Bioactive Materials, 25,168-169, Las Vegas, U.S.A. 

44.  N. Maitra, P.K. Ghosh and S. K. Sahoo; pH and thermo-sensitive hydrogel nanoparticles. Proceeding International Symposium on Controlled Release of Bioactive Materials, 25, 234-235. 1998, Las Vegas, U.S.A., 

45.  N. Maitra, S. K. Sahoo, P. K. Ghosh and T. K. De; Particle engineering of drug loaded nanoparticles and their potential drug targeting application preparation through microemulsion. 2nd International symposium on polymeric therapeutics from laboratory to clinical practice, April 18-20, 1997, Kumamoto University, Japan. 

46.  S. K. Sahoo, T. K. De and A. N. Maitra; Controlling the size of the hydrophilic polymeric nanoparticles preparation through microemulsion October 18-20, 1997, Center of Studies in Surface Science & Technology, Sambalpur University, Jyoti Vihar, Burla, India.  

 Invited Presentation/ Chair the Session 

Targeted dual drug loaded super paramagnetic iron oxide nanoparticles for cancer therapy, South African Nanosciences and Nanotechnology Summer School 23rd – 28th November, 2009. Pretoria, South Africa. 

Application of Nanotechnology in aquaculture:  Winter School on molecular and serological technics in fish disease diagnostics 9th -29th November, 2009, CIFA, Bhubaneswar, India. 

 Application of Nanomedicine: As an Emerging Platform for Cancer Therapy, International Conference in Nanomedicine, 14-16th August, 2009, Kochi, Kerala, India 

Nanotechnology in Pharmaceutical Sciences, Staff Development Programme 5th -18th of July, 2009, Roland Institute of Pharmaceutical Sciences Orissa, India 

Nanoparticle Interface: An Important determinant in nanoparticle-mediated drug/gene delivery delivery, National Seminar on “Biotechnology for Human Welfare and Property” 22nd March, 2009, Science College, Hinjilicut, Ganjam, Orissa, India 

Being a chairperson in a session at Indo-US Symposium on Cancer Nanotechnology, 4-6th February, 2009 

Nanoparticle Interface: An Important determinant in nanoparticle-mediated drug delivery, National Symposium on Cellular and Molecular Biophysics, 22nd to 24th January 2009, Centre for Cellular and molecular Biology, Hyderabad, India  

Nanotechnology: Application in human health care, 11th ORISSA BIGYAN CONGRESS, KIIT University, Bhubaneswar Date: 23-24th December 2008. 

Nanotechnology in drug delivery systems for the treatment of cancer, 19th November, 2008, Sri Jayadev College of Pharmaceutical Sciences - Orissa - Bhubaneswar-India. 

Being a chairperson in a session at 1st Internationational Stem Cell Summit, 14-16th November, 2008 

Ocular Drug Delivery:  Opportunities and Challenges, International Conference on Nano-medicine & Recent Advances in Opthalmic research. September 3-5th, 2008, Sankara Nethralaya, Chennai, India 

Nanoparticle Interface: An Important determinant in nanoparticles-mediated drug delivery Indo-US Workshop on Science and Technology at the Nano-Bio Interface, 19-22nd February, 2008, Bhubaneswar, India. 

Biodegradable Nanoparticle for Cancer Therapy International workshop on mesoscopic, nanoscopic and macroscopic materials, (iwmnmm-2008), 2-4th January, 2008, Bhubaneswar, India 

National Seminar on Emerging Trends in Pharmaceutical Education and Research, Royal College of Pharmacy and Health Sciences, Berhampur,20 - 22 July, 2007 

Workshop and short course attend 

1.    Attend the 12th Annual Short Course Advances in Tissue Engineering, August 11-14, 2004, Center for Biomedical Engineering, Rice University, Houston, Texas, USA 

2.    Attend a workshop in “Organised assemblies in solution “Center of studies in surface sciences and technology, February 22-27, 1996. Sambalpur University, Jyoti Vihar, Burla, Orissa, India 

The following technology has been transferred to Industry 

Formulation of Paclitaxel, its derivatives or its analogues entrapped into nanoparticles of polymeric micelles, Process for the preparing same and the use thereof. Technology has been transferred to Dabur Research Foundation, Dabur India Ltd, Sahibabad, Ghaziabad-201010, India. It is now at Phase  III clinical trial. 

Sustained release nanoparticle composition and methods for using the same. (US patent Application No-11/018, 456), Technology has been transferred to Tolomolecular Corporation, Ca, USA. It is now at Phase I, clinical trial

 

 
 

 
 
 

Site Maintaned by: Institute of Life Sciences

All rights reserved to Institute of Life Sciences
 For any suggestion or modification please mail to:  info@ils.res.in