Immunobiology of metazoan parasites

Area of Interest :
Immunology, Pathogenesis and Biology of pathogens causing Malaria and Helminthic diseases in human and experimental models, their transmisson and natural history and interactions with other infectious pathogens.

Publications in peer-reviewed journals ( last 10 years only) :

1. B.K.Das, S.Parida and B.Ravindran (1996) A prognostic role for anti-phosphatidyl choline antibodies in human cerebral malaria. Clinical and Experimental Immunology,103,442-445.
2.  B.K.Das, P.K.Sahoo and B.Ravindran (1996) A role for tumor necrosis factor-alpha in acute lymphatic filariasis.  Parasite Immunology,18,421-423.
3. S.Mukhopadhyay, A.P.Dash & B.Ravindran (1996) Setaria digitata microfilaraemia in Mastomys coucha - an animal model for Chemotheraptic and immunobiological study. Parasitology, 113, 323-330.
4. A.K.Satapathy and B.Ravindran (1996) A quantitative cell-ELISA for a-galactose specific antibodies in  human malaria . Journal of Immunoassay, 17,245-256.
5. S.Mukhopadhya and B.Ravindran (1997) Antibodies to diethylcarbamazine potentiate the antifilarial activity of the drug. Parasite Immunology,19, 191-195.
6. B.Ravindran, P.K.Sahoo & A.P.Dash (1998) Lymphatic filariasis and Malaria : Concomitant parasitism in Orissa, India. Transactions of the Royal Society of Tropical  Medicine and Hygiene,92,21-23.
7. B.Ravindran, P.K.Sahoo, M.C.Mohanty, S.Mukhopadhya and A.P.Dash(1999) Increased susceptibility of mice with XID mutation to Brugia malayi infection. Medical Science Research, 27,135-137.
8. S. Mukhopadhyay, P.K. Sahoo, A. George, V. Bal, S. Rath and B. Ravindran (1999) Delayed clearance of Filarial infection and enhanced Th1 immunity due to modulation of macrophage APC functions in XID mice. Journal of Immunology, 163, 1789-1792.
9. S.  Mukhopadhyay, A. George, V. Bal, B. Ravindran and S. Rath (1999) Bruton's tyrosine kinase deficiency in macrophages inhibits nitric oxide generation leading to enhancement of IL-12 induction.  Journal of Immunology, 163, 1786-1792.
10. A.K. Satapathy and B. Ravindran (1999) Naturally occurring alpha-galactosyl antibodies in human sera display polyreactivity. Immunology Letters, 69, 347-351.
11. P.K. Sahoo, J.J. Babu Geddam, A.K. Satapathy, M.c. Mohanty and B. Ravindran (2000). Bancroftian filariasis: prevalence of antigenaemia and endemic normals in Orissa, India. Transactions of the Royal Society of Tropical Medicine and Hygiene, 94: 515-517.
12. M.C. Mohanty, P.K. Sahoo, A.K. Satapathy and B. Ravindran (2000). Setaria digitata infections in cattle: parasite load, microfilaraemia status and relationship to immune response.  Journal of Helminthology, 74: 343-347.
13. B. Ravindran, A.K. Satapathy, P.K. Sahoo and J.J. Babu Geddam (2000). Protective immunity in human Bancroftian filariasis : Inverse relationship between antibodies to microfilarial sheath and circulating filarial antigens. Parasite Immunology, 22: 633-637.
14. C.H.Little, G.M.Georgion, G.Fey, B.Ravindran, J.Levine, H.Ogedegbe, H.Yamase and R.E.Cone (2000) Detection of antigen specific human serum proteins related to the T-cell receptor in infectious diseases and in an immune response to milk proteins and chemicals. Procedings of the Experimental Biology and Medicine. 224 : 264-272.
15. A.K. Satapathy, P.K. Sahoo, J.J. Babu Geddam, M.C. Mohanty and B. Ravindran (2001). Human bancroftian filariasis : Loss of patent microfilaraemia is not associated with production of antibodies in microfilarial sheath. Parasite Immunology, 23, 163-167.
16. B.Ravindran (2001) Are Inflammation and Immunological hyperactivity needed for Filarial Parasite development Trends in Parasitology, 17(2): 70-73.
17. M.C.Mohanty, A.K.Satapathy, P.K.Sahoo, and B.Ravindran (2001) Human Bancroftian Filariasis - A role for Antibodies to Parasite Carbohydrates. Clinical and Experimental Immunology, 124: 54-61.
18. B. Ravindran (2001) Filariasis Control: Ethics, Economics and Good Science. The Lancet, 358: 246.
19. M.C.Mohanty and B.Ravindran ( 2002) Deficiency of antibody responses to T-independent antigens in Gerbils, Mariones unguculatus. Developmental and Comparative Immunology, 26: 385-391.
20. P.K.Sahoo, J.J Babu Geddam, A.K.Satapathy, M.C.Mohanty, B.K.Das, A.S.Acharya , N.Mishra and B.Ravindran. (2002) Human Bancroftian Filariasis- A 13 year follow-up of Microfilariae carriers and Endemic Normals in Orissa, India. Parasitology, 124: 191-201.
21. S.Mukhophadya, M.C.Mohanty, A.Mangla, A.George,V.Bal,S.Rath and B.Ravindran (2002) Macrophage Effector functions controlled by Bruton's Tyrosine Kinase are more crucial than the cytokine balance of T-cell responses for microfilarial clearance. Journal of Immunology, 168: 2914-2921.
22. B.Ravindran (2002). Mass drug administration to treat lymphatic filariasis.    The Lancet 359 (9321): 1948.
23. B. Ravindran, A. K. Satapathy, P. K. Sahoo and M.C. Mohanty (2003) Protective immunity in human lymphatic filariasis: problems and prospects. Medical  Microbiology and Immunology, 192, 41-46
24. B. Ravindran (2003) Aping Jane Goodall: Insights into human lymphatic filariasis. Trends in Parasitology, 19(3), 105-109.
25. B.K.Das, S.Misra, P.K.padhi, R.Manish, R.Tripathy, P.K.Sahoo and    B.Ravindran (2003) Pentoxifyline adjunct improves prognosis of human cerebral malaria in adults. Tropical Medicine and International Health, 8; 680-684.
26. Mannan BA, Patel K, Malhotra I, Ravindran B and Sharma S. (2003) How specific is the immune response to malaria in adults living in endemic areas Journal of Vector Borne Diseases 40,(3-4): 84-91.
27. Mangla A, Khare A, Vineeth V, Panday NN, Mukhopadhyay A, Ravindran B, Bal V, George A and Rath S (2004) Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses. Blood, 104:1191-1198.
28. Rahmah, N., Ros Azeana, A.B, B. Ravindran. (2004) Homologs of the Brugia malayi diagnostic antigen BmR1 are present in other filarial parasites, but induce different humoral immune response  Filaria Journal, 3: 10.
29. Sahoo PK, Satapathy AK, Micheal E and Ravindran B (2005) Concomitant parasitism: Bancroftian filariasis and intestinal helminthes and response to albendazole. American Journal of Tropical Medicine and Hygiene (in press)
30. Sahu, BR, Mohapatra AD, Majumder A, Das P and Ravindran B (2005) A flow cytometry based method for studying embryogenesis and immune reactivity to embryonic stages in filarial parasites Filaria Journal (In Press)
31. Satapathy AK, Sartono E, Sahoo PK, Michael E, Yazdhanbakhsh M and Ravindran B (2006) Human Bancroftian Filariasis: Immunological Markers of morbidity and infection , Microbes and Infection (In Press)