Immunobiology of metazoan parasites

Area of Interest :
Immunology, Pathogenesis and Biology of pathogens causing Malaria and Helminthic diseases in human and experimental models, their transmisson and natural history and interactions with other infectious pathogens.

Publications in peer-reviewed journals ( last 10 years only) :

1. B.K.Das, S.Parida and B.Ravindran (1996) A prognostic role for anti-phosphatidyl choline antibodies in human cerebral malaria. Clinical and Experimental Immunology,103,442-445.

2.  B.K.Das, P.K.Sahoo and B.Ravindran (1996) A role for tumor necrosis factor-alpha in acute lymphatic filariasis.  Parasite Immunology,18,421-423.

3. S.Mukhopadhyay, A.P.Dash & B.Ravindran (1996) Setaria digitata microfilaraemia in Mastomys coucha - an animal model for Chemotheraptic and immunobiological study. Parasitology, 113, 323-330.

4. A.K.Satapathy and B.Ravindran (1996) A quantitative cell-ELISA for a-galactose specific antibodies in  human malaria . Journal of Immunoassay, 17,245-256.

5. S.Mukhopadhya and B.Ravindran (1997) Antibodies to diethylcarbamazine potentiate the antifilarial activity of the drug. Parasite Immunology,19, 191-195.

6. B.Ravindran, P.K.Sahoo & A.P.Dash (1998) Lymphatic filariasis and Malaria : Concomitant parasitism in Orissa, India. Transactions of the Royal Society of Tropical  Medicine and Hygiene,92,21-23.

7. B.Ravindran, P.K.Sahoo, M.C.Mohanty, S.Mukhopadhya and A.P.Dash(1999) Increased susceptibility of mice with XID mutation to Brugia malayi infection. Medical Science Research, 27,135-137.

8. S. Mukhopadhyay, P.K. Sahoo, A. George, V. Bal, S. Rath and B. Ravindran (1999) Delayed clearance of Filarial infection and enhanced Th1 immunity due to modulation of macrophage APC functions in XID mice. Journal of Immunology, 163, 1789-1792.

9. S.  Mukhopadhyay, A. George, V. Bal, B. Ravindran and S. Rath (1999) Bruton's tyrosine kinase deficiency in macrophages inhibits nitric oxide generation leading to enhancement of IL-12 induction.  Journal of Immunology, 163, 1786-1792.

10. A.K. Satapathy and B. Ravindran (1999) Naturally occurring alpha-galactosyl antibodies in human sera display polyreactivity. Immunology Letters, 69, 347-351.

11. P.K. Sahoo, J.J. Babu Geddam, A.K. Satapathy, M.c. Mohanty and B. Ravindran (2000). Bancroftian filariasis: prevalence of antigenaemia and endemic normals in Orissa, India. Transactions of the Royal Society of Tropical Medicine and Hygiene, 94: 515-517.

12. M.C. Mohanty, P.K. Sahoo, A.K. Satapathy and B. Ravindran (2000). Setaria digitata infections in cattle: parasite load, microfilaraemia status and relationship to immune response.  Journal of Helminthology, 74: 343-347.

13. B. Ravindran, A.K. Satapathy, P.K. Sahoo and J.J. Babu Geddam (2000). Protective immunity in human Bancroftian filariasis : Inverse relationship between antibodies to microfilarial sheath and circulating filarial antigens. Parasite Immunology, 22: 633-637.

14. C.H.Little, G.M.Georgion, G.Fey, B.Ravindran, J.Levine, H.Ogedegbe, H.Yamase and R.E.Cone (2000) Detection of antigen specific human serum proteins related to the T-cell receptor in infectious diseases and in an immune response to milk proteins and chemicals. Procedings of the Experimental Biology and Medicine. 224 : 264-272.

15. A.K. Satapathy, P.K. Sahoo, J.J. Babu Geddam, M.C. Mohanty and B. Ravindran (2001). Human bancroftian filariasis : Loss of patent microfilaraemia is not associated with production of antibodies in microfilarial sheath. Parasite Immunology, 23, 163-167.

16. B.Ravindran (2001) Are Inflammation and Immunological hyperactivity needed for Filarial Parasite development Trends in Parasitology, 17(2): 70-73.

17. M.C.Mohanty, A.K.Satapathy, P.K.Sahoo, and B.Ravindran (2001) Human Bancroftian Filariasis - A role for Antibodies to Parasite Carbohydrates. Clinical and Experimental Immunology, 124: 54-61.

18. B. Ravindran (2001) Filariasis Control: Ethics, Economics and Good Science. The Lancet, 358: 246.

19. M.C.Mohanty and B.Ravindran ( 2002) Deficiency of antibody responses to T-independent antigens in Gerbils, Mariones unguculatus. Developmental and Comparative Immunology, 26: 385-391.

20. P.K.Sahoo, J.J Babu Geddam, A.K.Satapathy, M.C.Mohanty, B.K.Das, A.S.Acharya , N.Mishra and B.Ravindran. (2002) Human Bancroftian Filariasis- A 13 year follow-up of Microfilariae carriers and Endemic Normals in Orissa, India. Parasitology, 124: 191-201.

21. S.Mukhophadya, M.C.Mohanty, A.Mangla, A.George,V.Bal,S.Rath and B.Ravindran (2002) Macrophage Effector functions controlled by Bruton's Tyrosine Kinase are more crucial than the cytokine balance of T-cell responses for microfilarial clearance. Journal of Immunology, 168: 2914-2921.

22. B.Ravindran (2002). Mass drug administration to treat lymphatic filariasis.    The Lancet 359 (9321): 1948.

23. B. Ravindran, A. K. Satapathy, P. K. Sahoo and M.C. Mohanty (2003) Protective immunity in human lymphatic filariasis: problems and prospects. Medical  Microbiology and Immunology, 192, 41-46

24. B. Ravindran (2003) Aping Jane Goodall: Insights into human lymphatic filariasis. Trends in Parasitology, 19(3), 105-109.

25. B.K.Das, S.Misra, P.K.padhi, R.Manish, R.Tripathy, P.K.Sahoo and    B.Ravindran (2003) Pentoxifyline adjunct improves prognosis of human cerebral malaria in adults. Tropical Medicine and International Health, 8; 680-684.

26. Mannan BA, Patel K, Malhotra I, Ravindran B and Sharma S. (2003) How specific is the immune response to malaria in adults living in endemic areas Journal of Vector Borne Diseases 40,(3-4): 84-91.

27. Mangla A, Khare A, Vineeth V, Panday NN, Mukhopadhyay A, Ravindran B, Bal V, George A and Rath S (2004) Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses. Blood, 104:1191-1198.

28. Rahmah, N., Ros Azeana, A.B, B. Ravindran. (2004) Homologs of the Brugia malayi diagnostic antigen BmR1 are present in other filarial parasites, but induce different humoral immune response  Filaria Journal, 3: 10.

29. Sahoo PK, Satapathy AK, Micheal E and Ravindran B (2005) Concomitant parasitism: Bancroftian filariasis and intestinal helminthes and response to albendazole. American Journal of Tropical Medicine and Hygiene (in press)

30. Sahu, BR, Mohapatra AD, Majumder A, Das P and Ravindran B (2005) A flow cytometry based method for studying embryogenesis and immune reactivity to embryonic stages in filarial parasites Filaria Journal (In Press)

31. Satapathy AK, Sartono E, Sahoo PK, Michael E, Yazdhanbakhsh M and Ravindran B (2006) Human Bancroftian Filariasis: Immunological Markers of morbidity and infection , Microbes and Infection (In Press)

32. Mand S, Supali T, Djuardi J, Kar S, Ravindran B, Hoerauf A. (2006) Detection of adult Brugia malayi filariae by ultrasonography in humans in India and Indonesia. Trop Med Int Health, 11(9):1375-81.

33. Noordin R, Itoh M, Kimura E, Abdul Rahman R, Ravindran B, Mahmud R, Supali T, Weerasooriya M. (2007) Multicentre evaluations of two new rapid IgG4 tests (WB rapid and panLF rapid) for detection of lymphatic filariasis. Filaria J. 2007 Oct 26;6:9.

34. Sahu BR, Mohanty MC, Sahoo PK, Satapathy AK, Ravindran B. (2008) Protective immunity in human filariasis: a role for parasite-specific IgA responses. J Infect Dis. 2008 Aug 1;198(3):434-43.

35. Mand S, Pfarr K, Sahoo PK, Satapathy AK, Specht S, Klarmann U, Debrah AY, Ravindran B, Hoerauf A. (2009) Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine. Am J Trop Med Hyg. 81(4):702-11

36. Gandhi V, Mehta K, Pathak S, Ravindran B, Mishra S, Aggarwal BB. (2010) City of temples discusses signaling templates in cancer cells. Third International Symposium on Translational Cancer Research: Cell Signaling & Cancer Therapy. Bhubaneswar, Orissa, India, December 18th through 21st, 2009. Anticancer Res.30(6):2477-80.

37. Khare A, Viswanathan B, Gund R, Jain N, Ravindran B, George A, Rath S, Bal V. (2011) Role of Bruton's tyrosine kinase in macrophage apoptosis. Apoptosis.16(4):334-46.

38. Panda AK, Sahoo PK, Kerketta AS, Kar SK, Ravindran B, Satapathy AK. (2011) Human lymphatic filariasis: genetic polymorphism of endothelin-1 and tumor necrosis factor receptor II correlates with development of chronic disease. J Infect Dis. 204(2):315-22.

39. Mohapatra AD, Kumar S, Satapathy AK, Ravindran B. (2011) Caspase dependent programmed cell death in developing embryos: a potential target for therapeutic intervention against pathogenic nematodes. PLoS Negl Trop Dis. 5(9):e1306. Epub 2011 Sep 13.

40. Panda AK, Panda SK, Sahu AN, Tripathy R, Ravindran B, Das BK. (2011) Association of ABO blood group with severe falciparum malaria in adults: case control study and meta-analysis. Malar J.10(1):309.

41. Panda, A.K., Parida, J.R., Tripathy, R., Pattanaik, S.S., Ravindran, B., Das, B.K., Low producer MBL genotypes are associated with susceptibility to systemic lupus erythematosus in Odisha, India, Human Immunology (2012), doi : http://dx.doi.org/10.1016/j.humimm.2012.09.003